| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T193 |
0-228 |
Sentence |
denotes |
To give some additional support to the potential of a receptor-immunoadhesin being a potential antiviral strategy, it should be noted that CD4-Fc or CD4-IgG was one of the early agents developed as a potential HIV medication 67. |
| T194 |
229-359 |
Sentence |
denotes |
The protein contained the first two domains of the CD4 receptor that are known to bind gp120 on the surface of infected HIV cells. |
| T195 |
360-427 |
Sentence |
denotes |
CD4-IgG was shown to neutralize HIV in vitro, preventing infection. |
| T196 |
428-552 |
Sentence |
denotes |
The protein was also safe when administered in patients, although only limited-to-mild clinical benefit was achieved 68, 69. |
| T197 |
553-891 |
Sentence |
denotes |
Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71. |
| T198 |
892-1105 |
Sentence |
denotes |
While HIV and 2019-nCoV are very different viruses, with different cell types, kinetics, and clinical courses, the previous results with HIV are encouraging that this could be a therapeutic strategy for 2019-nCoV. |
| T199 |
1106-1338 |
Sentence |
denotes |
If anything, 2019-nCoV is likely more amenable to this neutralizing therapy given that the respiratory virus will only cause an acute infection, unlike HIV, which causes chronic infection in hosts with different cellular reservoirs. |
