LitCovid-sentences  

PMC:7029759 / 2181-6461 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T16 0-12 Sentence denotes Introduction
T17 13-126 Sentence denotes A mysterious illness causing pneumonia in December 2019 in Wuhan, China is now growing into a potential pandemic.
T18 127-340 Sentence denotes These pneumonia cases were eventually characterized to be caused by a novel coronavirus (2019-nCoV) 1, of which Severe Acute Respiratory Syndrome (SARS) 2 and Middle East Respiratory Syndrome (MERS) 3 are members.
T19 341-436 Sentence denotes SARS and MERS famously caused their own outbreak concerns when they were originally identified.
T20 437-546 Sentence denotes SARS caused significant economic damage to Hong Kong and Southern China, before spreading to other countries.
T21 547-665 Sentence denotes Ultimately, SARS infected up to 8,098 people and caused 774 deaths according to the World Health Organization (WHO) 4.
T22 666-771 Sentence denotes The novel coronavirus, 2019-nCoV, is now quickly spreading across the world after originating in Wuhan 1.
T23 772-974 Sentence denotes Human-to-human transmission of 2019-nCoV has been confirmed in familial case cluster reports 5, as additional cases continue to be identified in different cities in China and countries around the world.
T24 975-1116 Sentence denotes Clinical symptoms of 2019-nCoV infection include fever, cough, and myalgia or fatigue with pneumonia demonstrated on chest CT scan imaging 6.
T25 1117-1425 Sentence denotes Within China, the city of Wuhan along with several others has been shut down, with individuals not allowed to leave the city in an effort to contain the virus; such efforts are largely unprecedented in a city of this size ( https://www.nytimes.com/2020/01/22/world/asia/coronavirus-quarantines-history.html).
T26 1426-1574 Sentence denotes For now, many travelers are being screened for fever (≥38°C) and reported recent history of travel to Wuhan in order to triage diagnostic testing 7.
T27 1575-1692 Sentence denotes These efforts resemble not only what happened with SARS in 2002–2003, but also the Ebola virus outbreak in 2014–2015.
T28 1693-1832 Sentence denotes During those outbreaks, special protocols were put in place to quarantine any infected individuals and identify patient contacts at risk 8.
T29 1833-1989 Sentence denotes Healthcare workers were also at risk, and despite extensive personal protective equipment measures, clinical providers did get infected in both outbreaks 9.
T30 1990-2196 Sentence denotes There were no specific, antiviral treatments for SARS or Ebola at the time of the outbreaks beyond supportive measures 10, 11, which is a similar situation that healthcare systems are facing with 2019-nCoV.
T31 2197-2331 Sentence denotes The dire situations facing patients in outbreak scenarios demand quick responses by the healthcare community and the biotech industry.
T32 2332-2541 Sentence denotes Unfortunately, many of the traditional options that guide drug development are inadequate for outbreaks; a process that takes years can’t help patients who are dying today, and economies that are being halted.
T33 2542-2658 Sentence denotes In these situations, studies have often been conducted on compassionate use, and clinical trial approvals expedited.
T34 2659-2778 Sentence denotes This was most recently seen in the 2014–2015 Ebola outbreak, where a variety of clinical trial candidates were studied.
T35 2779-2894 Sentence denotes Many of these therapies failed, but ultimately a vaccine did emerge that was fully protective against the virus 12.
T36 2895-3128 Sentence denotes It is important to note that, unlike the current situation with 2019-nCoV, Ebola had already been studied for years and this particular neutralizing vaccine made and tested in preclinical animal models years prior to the outbreak 13.
T37 3129-3418 Sentence denotes For 2019-nCoV, beyond knowing the sequence of spike (S) protein of the coronavirus (GenBank: MN908947.3), there are no studies on how immunogenic this particular protein will be beyond surrogate comparisons to SARS and MERS, which limits the potential ability to quickly produce a vaccine.
T38 3419-3707 Sentence denotes Moreover, while a vaccine would be greatly effective in helping to stop the spread of 2019-nCoV, an effective therapy is also needed for the patients infected with 2019-nCoV today, similar to the situation of Ebola patients needing effective therapies while vaccines were being developed.
T39 3708-3989 Sentence denotes In this article, I will outline different potential treatment options that could be pursued as a therapy for 2019-nCoV virus, keeping the focus on agents that could be rapidly tested in patients today and broadly effective in spite of limited knowledge of the biology of 2019-nCoV.
T40 3990-4122 Sentence denotes Simply stated, there is limited time for basic studies of 2019-nCoV in research labs, while patients need effective therapies today.
T41 4123-4280 Sentence denotes I finally propose the best potential treatment option in my opinion, along with instructions on how to manufacture the therapy for testing in patients today.