LitCovid-sentences  

PMC:7029759 / 20538-22069 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T131 0-146 Sentence denotes A second, similar strategy would be to administer an antibody that would bind to ACE2 protein, thereby preventing 2019-nCoV infection ( Figure 1).
T132 147-237 Sentence denotes This strategy was shown to effectively block SARS entry and replication in experiments 42.
T133 238-414 Sentence denotes While no ACE2 antibody sequences are published in literature indexes, monoclonal antibodies do exist and the associated hybridoma sequences could be cloned in a matter of days.
T134 415-566 Sentence denotes There would be no concern for any viral escape from an ACE2 binding antibody, which is an advantage over neutralizing approaches against the S protein.
T135 567-672 Sentence denotes There are a couple of design considerations when thinking about how to employ the ACE2 antibody strategy.
T136 673-824 Sentence denotes Any effector functions would need to be removed from the Fc domain 49, such that inflammation would not be caused in different tissues expressing ACE2.
T137 825-919 Sentence denotes This would retain the long-half life endowed by the Fc domain without any of the side effects.
T138 920-1162 Sentence denotes The downside of including the Fc domain is the need to use a more expensive mammalian cell production system to preserve proper glycosylation, which would decrease the turnaround time for getting the drug to patients in the outbreak scenario.
T139 1163-1263 Sentence denotes Alternatively, one could just administer a single chain variable fragment (scFv) that binds to ACE2.
T140 1264-1338 Sentence denotes A nanobody or VHH domains from camelids are another option as well 50, 51.
T141 1339-1451 Sentence denotes These could be produced in bacteria, and its small size would allow for rapid permeation into different tissues.
T142 1452-1531 Sentence denotes The downside is the shorter half-life of these molecules without the Fc domain.