| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T122 |
0-9 |
Sentence |
denotes |
Figure 1. |
| T123 |
11-89 |
Sentence |
denotes |
Therapeutic agents that could be used to block 2019-nCoV from infecting cells. |
| T124 |
90-179 |
Sentence |
denotes |
Target cells expressing ACE2 include lung and gastrointestinal tissues in the human body. |
| T125 |
180-293 |
Sentence |
denotes |
The large spike protein on the surface of the coronavirus binds to ACE2 on infected cells, leading to cell entry. |
| T126 |
294-374 |
Sentence |
denotes |
Three proposed strategies would block this interaction would abrogate infection. |
| T127 |
375-542 |
Sentence |
denotes |
In the first, the receptor-binding domain (RBD) of the spike protein from SARS or 2019-nCoV would be administered, thereby binding ACE2 and saturating available sites. |
| T128 |
543-669 |
Sentence |
denotes |
Alternatively, an antibody or single chain antibody fragment (scFv) could be administered against ACE2 to accomplish the same. |
| T129 |
670-805 |
Sentence |
denotes |
A third strategy would target the coronavirus virions directly by using the ACE2 extracellular domain as bait to bind to spike protein. |
| T130 |
806-898 |
Sentence |
denotes |
An Fc domain fused to ACE2 would facilitate prolonged circulation of the biologic (ACE2-Fc). |
