| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T98 |
0-126 |
Sentence |
denotes |
However, there is another strategy to pursue in this scenario that does not rely on targeting the viral glycoprotein directly. |
| T99 |
127-310 |
Sentence |
denotes |
In this strategy, a neutralizing effect could be obtained by targeting the viral receptor protein on the cell surface, thereby blocking the virus from binding to it and gaining entry. |
| T100 |
311-409 |
Sentence |
denotes |
Fortunately, scientists have already uncovered the identity of the viral receptor in cell culture. |
| T101 |
410-618 |
Sentence |
denotes |
A recent pre-print publication found that the 2019-nCoV uses the angiotensin-converting enzyme 2 (ACE2) as a receptor for cell entry 41, which is the same receptor that the SARS coronavirus uses for entry 42. |
| T102 |
619-774 |
Sentence |
denotes |
For both viruses, the coronavirus binds to ACE2 through its S protein on the virion, where after fusion of the viral membrane and cell membrane will occur. |
| T103 |
775-922 |
Sentence |
denotes |
Subsequently, the RNA virus will replicate its genome inside the cell, and ultimately make new virions that will be secreted to infect other cells. |
| T104 |
923-1089 |
Sentence |
denotes |
The coincidence of SARS and 2019-nCoV using ACE2 receptor opens up the possibility of using the extensive research studied on SARS entry and applying it to 2019-nCoV. |
| T105 |
1090-1251 |
Sentence |
denotes |
Based on the SARS literature, several potential blocking strategies could be considered, which were shown to be effective in preventing infection in SARS models. |
