LitCovid-sentences  

PMC:7029759 / 11579-13230 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T73 0-167 Sentence denotes Ideal agents to fight 2019-nCoV would be approved small molecule drugs that could inhibit different aspects of the viral life cycle, ultimately inhibiting replication.
T74 168-368 Sentence denotes Two classes of potential targets are viral polymerases 28 and protease inhibitors 29, both of which are components of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) antiviral regimens.
T75 369-480 Sentence denotes Pilot clinical studies are already ensuing by desperate clinicians with various repurposed antiviral medicines.
T76 481-584 Sentence denotes This has been done in every viral outbreak previously with limited success, outside of case reports 30.
T77 585-742 Sentence denotes Indeed, during the Ebola outbreak, none of the repurposed small molecule drugs were definitively shown to improve the clinical course across all patients 31.
T78 743-980 Sentence denotes The 2019-nCoV could be different, and there are initial positive reports that lopinavir and ritonavir, which are HIV protease inhibitors, have some clinical efficacy against 2019-nCoV, similar to prior studies using them against SARS 32.
T79 981-1225 Sentence denotes Research should continue to be undertaken to screen other clinically available antivirals in cell culture models of 2019-nCoV, in hopes that a drug candidate would emerge useful against the virus that could be rapidly implemented in the clinic.
T80 1226-1367 Sentence denotes One promising example could be remdesivir, which interferes with the viral polymerase and has shown efficacy against MERS in mouse models 33.
T81 1368-1476 Sentence denotes For further information, reviews of previous drug repurposing efforts for coronaviruses are provided 34, 35.
T82 1477-1651 Sentence denotes Though these repurposed medications may hold promise, it is still reasonable to pursue novel, 2019-nCoV specific therapies to complement potential repurposed drug candidates.