LitCovid-sentences  

PMC:7029449 / 5453-8651 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T30 0-29 Sentence denotes Disease severity and immunity
T31 30-198 Sentence denotes The first human infections were identified through a surveillance system for pneumonia of unknown aetiology, and all of the earliest infections therefore had pneumonia.
T32 199-508 Sentence denotes It is well established that some infections can be severe, particularly in older adults with underlying medical conditions [15,16], but based on the generally mild clinical presentation of 2019-nCoV cases detected outside China, it appears that there could be many more mild infections than severe infections.
T33 509-701 Sentence denotes Determining the spectrum of clinical manifestations of 2019-nCoV infections is perhaps the most urgent research priority, because it determines the strength of public health response required.
T34 702-953 Sentence denotes If the seriousness of infection is similar to the 1918/19 Spanish influenza, and therefore at the upper end of severity scales in influenza pandemic plans, the same responses would be warranted for 2019-nCoV as for the most severe influenza pandemics.
T35 954-1111 Sentence denotes If, however, the seriousness of infection is similar to seasonal influenza, especially during milder seasons, mitigation measures could be tuned accordingly.
T36 1112-1211 Sentence denotes Beyond a robust assessment of overall severity, it is also important to determine high risk groups.
T37 1212-1466 Sentence denotes Infections would likely be more severe in older adults, obese individuals or those with underlying medical conditions, but there have not yet been reports of severity of infections in pregnant women, and very few cases have been reported in children [2].
T38 1467-1687 Sentence denotes Those under 18 years are a critical group to study in order to tease out the relative roles of susceptibility vs severity as possible underlying causes for the very rare recorded instances of infection in this age group.
T39 1688-1766 Sentence denotes Are children protected from infection or do they not fall ill after infection?
T40 1767-1935 Sentence denotes If they are naturally immune, which is unlikely, we should understand why; otherwise, even if they do not show symptoms, it is important to know if they shed the virus.
T41 1936-2067 Sentence denotes Obviously, the question about virus shedding of those being infected but asymptomatic leads to the crucial question of infectivity.
T42 2068-2326 Sentence denotes Answers to these questions are especially pertinent as basis for decisions on school closure as a social distancing intervention, which can be hugely disruptive not only for students but also because of its knock-on effect for child care and parental duties.
T43 2327-2496 Sentence denotes Very few children have been confirmed 2019-nCoV cases so far but that does not necessarily mean that they are less susceptible or that they could not be latent carriers.
T44 2497-2612 Sentence denotes Serosurveys in affected locations could inform this, in addition to truly assessing the clinical severity spectrum.
T45 2613-2818 Sentence denotes Another question on susceptibility is regarding whether 2019-nCoV infection confers neutralising immunity, usually but not always, indicated by the presence of neutralising antibodies in convalescent sera.
T46 2819-2987 Sentence denotes Some experts already questioned whether the 2019-nCoV may behave similarly to MERS-CoV in cases exhibiting mild symptoms without eliciting neutralising antibodies [17].
T47 2988-3105 Sentence denotes A separate question pertains to the possibility of antibody-dependent enhancement of infection or of disease [18,19].
T48 3106-3198 Sentence denotes If either of these were to be relevant, the transmission dynamics could become more complex.