PMC:7003341 / 28665-41279 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T242 0-23 Sentence denotes 5.3 Imaging examination
T243 25-65 Sentence denotes 5.3.1 CT imaging (strong recommendation)
T244 66-216 Sentence denotes The imaging findings vary with the patient’s age, immunity status, disease stage at the time of scanning, underlying diseases, and drug interventions.
T245 217-819 Sentence denotes The imaging features of lesions show: (1) dominant distribution (mainly subpleural, along the bronchial vascular bundles); (2) quantity (often more than three or more lesions, occasional single or double lesions); (3) shape (patchy, large block, nodular, lumpy, honeycomb-like or grid-like, cord-like, etc.); (4) density (mostly uneven, a paving stones-like change mixed with ground glass density and interlobular septal thickening, consolidation and thickened bronchial wall, etc.); and (5) concomitant signs vary (air-bronchogram, rare pleural effusion and mediastinal lymph nodes enlargement, etc.).
T246 821-883 Sentence denotes 5.3.2 Clinical data from Zhongnan Hospital of Wuhan University
T247 885-934 Sentence denotes Typical CT/X-ray imaging manifestation, including
T248 935-1023 Sentence denotes Multiple, patchy, sub-segmental or segmental ground-glass density shadows in both lungs.
T249 1024-1146 Sentence denotes They were classified as “paving stone-like” changes by fine-grid or small honeycomb-like thickening of interlobular septa.
T250 1147-1268 Sentence denotes The thinner the CT scan layers, the clearer the ground-glass opacity and thickening of interlobular septa were displayed.
T251 1269-1481 Sentence denotes A slightly high-density and ground-glass change with fuzzy edge in the fine-grid or small honeycomb-like thickening of interlobular septa were presented by the high-resolution computed tomography (HRCT), (Fig. 1:
T252 1482-1522 Sentence denotes 45 cases, 54.2% in a total of 83 cases).
T253 1523-1679 Sentence denotes The resolution of X-ray was worse lower than that of CT in the resolution, which was basically manifested as ground-glass opacities with fuzzy edge (Fig. 2:
T254 1680-1719 Sentence denotes 9 cases, 10.8% in a total of 83 cases).
T255 1720-1769 Sentence denotes Fig. 1 Typical CT imaging manifestation (case 1).
T256 1770-1883 Sentence denotes A 38 years old male with fever without obvious inducement (39.3 ℃), dry cough and shortness of breath for 3 days.
T257 1884-2149 Sentence denotes Laboratory test: normal white blood cells (6.35 × 109/L), decreased lymphocytes percentage (4.1%), decreased lymphocytes count (0.31 × 109/L), decreased eosinophil count (0 × 109/L)), increased C-reaction protein (170.91 mg/L), increased procalcitonin (0.45 ng/ml).
T258 2150-2291 Sentence denotes Imaging examination: multiple patches, grid-like lobule and thickening of interlobular septa, typical “paving stone-like” signs. a SL(Slice):
T259 2292-2342 Sentence denotes 6 mm; b high-resolution computed tomography(HRCT).
T260 2343-2384 Sentence denotes HRCT. high-resolution computed tomography
T261 2385-2442 Sentence denotes Fig. 2 Typical CT / X-ray imaging manifestation (case 2).
T262 2443-2545 Sentence denotes A 51 years old male with general muscle ache and fatigue for 1 week, fever for 1 day (39.1 ℃), anemia.
T263 2546-2847 Sentence denotes Laboratory test: normal white blood cells (9.24 × 109/L), lymphocytes percentage (5.1%), decreased lymphocytes (0.47 × 109/ L), decreased eosinophil count (0 × 109/L), increased C-reaction protein (170.91 mg/L), increased procalcitonin (0.45 ng/ml), increased erythrocyte sedimentation rate (48 mm/h).
T264 2848-3199 Sentence denotes Imaging examination: a shows patchy shadows in the outer region of the left lower lobe, b shows large ground-glass opacity in the left lower lobe, and c shows subpleural patchy ground-glass opacity in posterior part of right upper lobe and lower tongue of left upper lobe, d shows large ground-glass opacity in the basal segment of the left lower lobe
T265 3200-3395 Sentence denotes (2) Multiple, patchy or large patches of consolidation in both lungs, with a little grid-like or honeycomb-shaped interlobular septal thickening, especially in the middle and lower lobes (Fig. 3:
T266 3396-3436 Sentence denotes 26 cases, 31.3% in a total of 83 cases).
T267 3437-3500 Sentence denotes It was more common in the elderly or severe condition patients.
T268 3501-3558 Sentence denotes Fig. 3 Typical CT / X-ray imaging manifestation (case 3).
T269 3559-3610 Sentence denotes A 65 years old male with fever for 4 days (38.7 ℃).
T270 3611-3884 Sentence denotes Laboratory test: normal white blood cells (3.72 × 109/L), decreased lymphocytes (0.9 × 109/ L), decreased eosinophil count (0 × 109/L), increased C-reaction protein (53.0 mg/L), increased procalcitonin (0.10 ng/ml), reduced liver function, hypoproteinemia, and mild anemia.
T271 3885-4211 Sentence denotes Imaging examination: a and b showed large consolidation in the right middle lobe, patchy consolidation in the posterior and basal segment of the right lower lobe, with air-bronchogram inside, c showed patchy consolidation in the outer and basal segment of the left lower lobe, and a small amount of effusion in the right chest
T272 4213-4263 Sentence denotes Atypical CT/X-ray imaging manifestation, including
T273 4264-4449 Sentence denotes Single, or multiple, or extensive subpleural grid-like or honeycomb-like thickening of interlobular septum, thickening of the bronchial wall, and tortuous and thick strand-like opacity.
T274 4450-4594 Sentence denotes Several patchy consolidations, occasionally with a small amount pleural effusion or enlargement of mediastinal lymph nodes, can be seen (Fig. 4:
T275 4595-4633 Sentence denotes 6 cases, 7.2% in a total of 83 cases).
T276 4634-4669 Sentence denotes This is mostly seen in the elderly.
T277 4670-4728 Sentence denotes Fig. 4 Atypical CT / X-ray imaging manifestation (case 1).
T278 4729-4920 Sentence denotes An 83 years old female with fever for 4 days (maximum temperature of 38.8 ℃), cough, chills, sore throat, dry cough for 1 week, chest tightness and shortness of breath aggravating for 1 week.
T279 4921-5057 Sentence denotes Laboratory test: normal white blood cells (4.6 × 109/L), normal neutrophil percentage (65.8%), decreased lymphocytes percentage (19.9%).
T280 5058-5326 Sentence denotes Imaging examination: a and b showed diffuse interlobular septum thickening in both lungs to form a grid opacity, thickening of bronchial wall, and consolidation in the left sublobal lung. c showed diffused grid-like opacities in both lungs, especially in the left lung
T281 5327-5458 Sentence denotes (2) Single or multiple solid nodules or consolidated nodules in the center of lobule, surrounded by ground-glass opacities (Fig. 5:
T282 5459-5497 Sentence denotes 5 cases, 6.2% in a total of 83 cases).
T283 5498-5556 Sentence denotes Fig. 5 Atypical CT / X-ray imaging manifestation (case 2).
T284 5557-5601 Sentence denotes A 56 years old female with fever for 3 days.
T285 5602-5920 Sentence denotes Laboratory test: decreased total protein (54.0 g/L),decreased albumin (35.5 g/L),decreased globulin (18.5 g/L), normal white blood cells (4.87 × 109/L), decreased lymphocytes percentage (10.1%), decreased lymphocytes (0.49 × 109/ L), decreased eosinophil count (0 × 109/L)), decreased eosinophil count percentage (0%).
T286 5921-6439 Sentence denotes Imaging examination: a showed two consolidation nodulesat the center of the lateral segment of middle lobe of the right lung which was surrounded by ground-glass opacities; b showed patchy ground-glass opacity in the anterior segment of the right upper lung with patchy consolidation lesions in it; c showed patchy ground-glass opacities in both lungs with patchy consolidation lesions in it. d showed patchy consolidation in the ground-glass opacities in the middle lobe and dorsal segment of lower lobe of right lung
T287 6441-6464 Sentence denotes Stage based on CT image
T288 6465-6582 Sentence denotes The CT imaging demonstrates 5 stages according to the time of onset and the response of body to the virus, including:
T289 6583-6601 Sentence denotes Ultra-early stage.
T290 6602-6941 Sentence denotes This stage usually refers to the stage of patients without clinical manifestation, negative laboratory test but positive throat swab for 2019-nCoV within 1–2 weeks after being exposed to a virus-contaminated environment (history of contact with a patient or patient-related family members, unit, or medical staff in a cluster environment).
T291 6942-7237 Sentence denotes The main imaging manifestations are single, double or scattered focal ground-glass opacity, nodules located in central lobule surrounded by patchy ground-glass opacities, patchy consolidation and sign of intra-bronchial air-bronchogram, which was dominant in the middle and lower pleura (Fig. 6:
T292 7238-7276 Sentence denotes 7 cases, 8.4% in a total of 83 cases).
T293 7277-7630 Sentence denotes Fig. 6 CT imaging of ultra-early stage. a A 33 years old female with patchy ground-glass opacities after occupational exposure. b A 67 years old male with a history of contact with infected patients, showing large ground-glass opacity. c A 35 years old female exhibiting large consolidated opacity with air-bronchogram inside after occupational exposure
T294 7631-7753 Sentence denotes (2) Early stage.This stage refers to the period of 1–3 days after clinical manifestations (fever, cough, dry cough, etc.).
T295 7754-7930 Sentence denotes The pathological process during this stage is dilatation and congestion of alveolar septal capillary, exudation of fluid in alveolar cavity and interlobular interstitial edema.
T296 7931-8103 Sentence denotes It showed that single or multiple scattered patchy or agglomerated ground-glass opacities, separated by honeycomb-like or grid-like thickened of interlobular septa (Fig. 7:
T297 8104-8144 Sentence denotes 45 cases, 54.2% in a total of 83 cases).
T298 8145-8178 Sentence denotes Fig. 7 CT imaging of early stage.
T299 8179-8287 Sentence denotes Male, 38 years old, fever without obvious inducement (39.3 ℃), dry cough and shortness of breath for 3 days.
T300 8288-8467 Sentence denotes Laboratory test: decreased white blood cells (3.01 × 109/L), decreased lymphocytes (0.81 × 109/ L), increased C-reaction protein (60.8 mg/L), increased procalcitonin (0.16 ng/ml).
T301 8468-8640 Sentence denotes Imaging examination: a (thin layer CT) and b (high-resolution CT) showed multiple patchy and light consolidation in both lungs and grid-like thickness of interlobular septa
T302 8641-8669 Sentence denotes (3) Rapid progression stage.
T303 8670-9012 Sentence denotes This stage refers to the period about 3–7 days after clinical manifestations started, the pathological features in this stage are the accumulation of a large number of cell-rich exudates in the alveolar cavity, vascular expansion and exudation in the interstitium, both of which lead to further aggravation of alveolar and Interstitial edema.
T304 9013-9114 Sentence denotes The fibrous exudation connects each alveolus through the inter-alveolar space to form a fusion state.
T305 9115-9213 Sentence denotes The CT manifested a fused and large-scale light consolidation with air-bronchogram inside (Fig. 8:
T306 9214-9254 Sentence denotes 17 cases, 20.5% in a total of 83 cases).
T307 9255-9300 Sentence denotes Fig. 8 CT imaging of rapid progression stage.
T308 9301-9443 Sentence denotes A 50 years old female with anorexia, fatigue, muscle soreness, nasal congestion and runny nose for 1 week, sore and itching throat for 2 days.
T309 9444-9634 Sentence denotes Laboratory test: increased erythrocyte sedimentation rate (25 mm/h), normal white blood cells (4.08 × 109/L), decreased lymphocytes (0.96 × 109/ L), increased C-reaction protein (60.8 mg/L).
T310 9635-9806 Sentence denotes Imaging examination: a (thin layer CT) and b (high-resolution CT) showed multiplepatchy and light consolidation in both lungs and grid-like thickness of interlobular septa
T311 9807-9831 Sentence denotes (4) Consolidation stage.
T312 9832-9920 Sentence denotes This stage refers to the period around 7–14 days after clinical manifestations appeared.
T313 9921-10082 Sentence denotes The main pathological features in this stage are the fibrous exudation of the alveolar cavity and the disappearance of capillary congestion in the alveolar wall.
T314 10083-10215 Sentence denotes CT imaging showed the multiple patchy consolidations in slighter density and smaller range than that of the previous stage. (Fig. 9:
T315 10216-10256 Sentence denotes 26 cases, 31.2% in a total of 83 cases).
T316 10257-10298 Sentence denotes Fig. 9 CT imaging of consolidation stage.
T317 10299-10360 Sentence denotes A 65 years old male with fever (maximum temperature of 39 ℃).
T318 10361-10861 Sentence denotes Laboratory test: hypoproteinemia (decreased total protein (62.20 g/L), decreased albumin (35.70 g/L)), abnormal liver function (increased alanine aminotransferase (79 U/L), increased aspartate aminotransferase (72 U/L)), increased procalcitonin (0.10 ng/ml), increased C-reaction protein (53 mg/L), decreased white blood cells (3.72 × 109/L), decreased lymphocytes (0.9 × 109/ L), mildanemia (decreased red blood cells (4.10 × 1012/L), decreased hemoglobin (131.10 g/L), decreased hematocrit (39.0%).
T319 10862-11118 Sentence denotes Imaging examination: a (thin layer CT) and b (high-resolution CT) showedmultiple patchyand large consolidation in right middle lobe, posterior and basal segment of right lower lobe and outer and basal segment of left lower lobe, with air-bronchogram inside
T320 11119-11141 Sentence denotes (5) Dissipation stage.
T321 11142-11247 Sentence denotes This stage refers to the period roughly between 2 and 3 weeks after the onset of clinical manifestations.
T322 11248-11289 Sentence denotes The range of lesions was further reduced.
T323 11290-11351 Sentence denotes CT imaging showed patchy consolidation or strip-like opacity.
T324 11352-11525 Sentence denotes As time goes on, it showed grid-like thickening of interlobular septum, thickening and strip-like twist of bronchial wall and a few scattered patchy consolidations (Fig. 10:
T325 11526-11566 Sentence denotes 17 cases, 20.5% in a total of 83 cases).
T326 11567-11607 Sentence denotes Fig. 10 CT imaging of dissipation stage.
T327 11608-11654 Sentence denotes A 79 years old female with intermittent fever.
T328 11655-12126 Sentence denotes Laboratory test after 3 days of comprehensive treatment: decreased red blood cells (3.73 × 1012/L), hemoglobin (107 g/L), decreased hematocrit (31.8%), decreased lymphocytes percentage (13.9%), decreased lymphocytes (0.62 × 109/ L), decreased eosinophil count percentage (0%), decreased eosinophil count (0 × 109/L), increased alanine aminotransferase (46 U/L), deceased total protein (56.8 g/L), decreased albumin (33.5 g/L), normal C-reaction protein and procalcitonin.
T329 12127-12614 Sentence denotes Imaging examination: a patchy ground-glass opacity and grid-like thickening of interlobular septa in the tongue-like segment of left upper lobe, and patchy consolidation in the posterior segment of right middle and lower lobe. b 9 days after admission to hospotial, CT scan showed absorption of lesions in the middle lobe, narrowing of lesions in the lower lobe of the right lung, and absorption of lesions in the tongue-like segment of left upper lobe which exhibited a cord-like change