| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-127 |
Sentence |
denotes |
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. |
| TextSentencer_T2 |
128-139 |
Sentence |
denotes |
Importance: |
| TextSentencer_T3 |
140-303 |
Sentence |
denotes |
In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. |
| TextSentencer_T4 |
304-410 |
Sentence |
denotes |
Information about the clinical characteristics of infected patients who require intensive care is limited. |
| TextSentencer_T5 |
411-421 |
Sentence |
denotes |
Objective: |
| TextSentencer_T6 |
422-572 |
Sentence |
denotes |
To characterize patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy. |
| TextSentencer_T7 |
573-607 |
Sentence |
denotes |
Design, Setting, and Participants: |
| TextSentencer_T8 |
608-968 |
Sentence |
denotes |
Retrospective case series of 1591 consecutive patients with laboratory-confirmed COVID-19 referred for ICU admission to the coordinator center (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy) of the COVID-19 Lombardy ICU Network and treated at one of the ICUs of the 72 hospitals in this network between February 20 and March 18, 2020. |
| TextSentencer_T9 |
969-1012 |
Sentence |
denotes |
Date of final follow-up was March 25, 2020. |
| TextSentencer_T10 |
1013-1161 |
Sentence |
denotes |
Exposures: SARS-CoV-2 infection confirmed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swabs. |
| TextSentencer_T11 |
1162-1189 |
Sentence |
denotes |
Main Outcomes and Measures: |
| TextSentencer_T12 |
1190-1318 |
Sentence |
denotes |
Demographic and clinical data were collected, including data on clinical management, respiratory failure, and patient mortality. |
| TextSentencer_T13 |
1319-1464 |
Sentence |
denotes |
Data were recorded by the coordinator center on an electronic worksheet during telephone calls by the staff of the COVID-19 Lombardy ICU Network. |
| TextSentencer_T14 |
1465-1473 |
Sentence |
denotes |
Results: |
| TextSentencer_T15 |
1474-1585 |
Sentence |
denotes |
Of the 1591 patients included in the study, the median (IQR) age was 63 (56-70) years and 1304 (82%) were male. |
| TextSentencer_T16 |
1586-1696 |
Sentence |
denotes |
Of the 1043 patients with available data, 709 (68%) had at least 1 comorbidity and 509 (49%) had hypertension. |
| TextSentencer_T17 |
1697-1958 |
Sentence |
denotes |
Among 1300 patients with available respiratory support data, 1287 (99% [95% CI, 98%-99%]) needed respiratory support, including 1150 (88% [95% CI, 87%-90%]) who received mechanical ventilation and 137 (11% [95% CI, 9%-12%]) who received noninvasive ventilation. |
| TextSentencer_T18 |
1959-2087 |
Sentence |
denotes |
The median positive end-expiratory pressure (PEEP) was 14 (IQR, 12-16) cm H2O, and Fio2 was greater than 50% in 89% of patients. |
| TextSentencer_T19 |
2088-2132 |
Sentence |
denotes |
The median Pao2/Fio2 was 160 (IQR, 114-220). |
| TextSentencer_T20 |
2133-2370 |
Sentence |
denotes |
The median PEEP level was not different between younger patients (n = 503 aged ≤63 years) and older patients (n = 514 aged ≥64 years) (14 [IQR, 12-15] vs 14 [IQR, 12-16] cm H2O, respectively; median difference, 0 [95% CI, 0-0]; P = .94). |
| TextSentencer_T21 |
2371-2413 |
Sentence |
denotes |
Median Fio2 was lower in younger patients: |
| TextSentencer_T22 |
2414-2565 |
Sentence |
denotes |
60% (IQR, 50%-80%) vs 70% (IQR, 50%-80%) (median difference, -10% [95% CI, -14% to 6%]; P = .006), and median Pao2/Fio2 was higher in younger patients: |
| TextSentencer_T23 |
2566-2660 |
Sentence |
denotes |
163.5 (IQR, 120-230) vs 156 (IQR, 110-205) (median difference, 7 [95% CI, -8 to 22]; P = .02). |
| TextSentencer_T24 |
2661-2944 |
Sentence |
denotes |
Patients with hypertension (n = 509) were older than those without hypertension (n = 526) (median [IQR] age, 66 years [60-72] vs 62 years [54-68]; P < .001) and had lower Pao2/Fio2 (median [IQR], 146 [105-214] vs 173 [120-222]; median difference, -27 [95% CI, -42 to -12]; P = .005). |
| TextSentencer_T25 |
2945-3197 |
Sentence |
denotes |
Among the 1581 patients with ICU disposition data available as of March 25, 2020, 920 patients (58% [95% CI, 56%-61%]) were still in the ICU, 256 (16% [95% CI, 14%-18%]) were discharged from the ICU, and 405 (26% [95% CI, 23%-28%]) had died in the ICU. |
| TextSentencer_T26 |
3198-3364 |
Sentence |
denotes |
Older patients (n = 786; age ≥64 years) had higher mortality than younger patients (n = 795; age ≤63 years) (36% vs 15%; difference, 21% [95% CI, 17%-26%]; P < .001). |
| TextSentencer_T27 |
3365-3391 |
Sentence |
denotes |
Conclusions and Relevance: |
| TextSentencer_T28 |
3392-3642 |
Sentence |
denotes |
In this case series of critically ill patients with laboratory-confirmed COVID-19 admitted to ICUs in Lombardy, Italy, the majority were older men, a large proportion required mechanical ventilation and high levels of PEEP, and ICU mortality was 26%. |
