| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-109 |
Sentence |
denotes |
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. |
| TextSentencer_T2 |
110-182 |
Sentence |
denotes |
The COVID-19 pandemic caused by SARS-CoV-2 is a global health emergency. |
| TextSentencer_T3 |
183-362 |
Sentence |
denotes |
An attractive drug target among coronaviruses is the main protease (Mpro, 3CLpro), due to its essential role in processing the polyproteins that are translated from the viral RNA. |
| TextSentencer_T4 |
363-474 |
Sentence |
denotes |
We report the X-ray structures of the unliganded SARS-CoV-2 Mpro and its complex with an α-ketoamide inhibitor. |
| TextSentencer_T5 |
475-644 |
Sentence |
denotes |
This was derived from a previously designed inhibitor but with the P3-P2 amide bond incorporated into a pyridone ring to enhance the half-life of the compound in plasma. |
| TextSentencer_T6 |
645-904 |
Sentence |
denotes |
Based on the structure, we developed the lead compound into a potent inhibitor of the SARS-CoV-2 Mpro The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route. |
