Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-117 |
Sentence |
denotes |
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. |
TextSentencer_T2 |
118-129 |
Sentence |
denotes |
Importance: |
TextSentencer_T3 |
130-229 |
Sentence |
denotes |
In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. |
TextSentencer_T4 |
230-352 |
Sentence |
denotes |
The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited. |
TextSentencer_T5 |
353-363 |
Sentence |
denotes |
Objective: |
TextSentencer_T6 |
364-433 |
Sentence |
denotes |
To describe the epidemiological and clinical characteristics of NCIP. |
TextSentencer_T7 |
434-468 |
Sentence |
denotes |
Design, Setting, and Participants: |
TextSentencer_T8 |
469-714 |
Sentence |
denotes |
Retrospective, single-center case series of the 138 consecutive hospitalized patients with confirmed NCIP at Zhongnan Hospital of Wuhan University in Wuhan, China, from January 1 to January 28, 2020; final date of follow-up was February 3, 2020. |
TextSentencer_T9 |
715-725 |
Sentence |
denotes |
Exposures: |
TextSentencer_T10 |
726-742 |
Sentence |
denotes |
Documented NCIP. |
TextSentencer_T11 |
743-770 |
Sentence |
denotes |
Main Outcomes and Measures: |
TextSentencer_T12 |
771-884 |
Sentence |
denotes |
Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. |
TextSentencer_T13 |
885-966 |
Sentence |
denotes |
Outcomes of critically ill patients and noncritically ill patients were compared. |
TextSentencer_T14 |
967-1168 |
Sentence |
denotes |
Presumed hospital-related transmission was suspected if a cluster of health professionals or hospitalized patients in the same wards became infected and a possible source of infection could be tracked. |
TextSentencer_T15 |
1169-1177 |
Sentence |
denotes |
Results: |
TextSentencer_T16 |
1178-1319 |
Sentence |
denotes |
Of 138 hospitalized patients with NCIP, the median age was 56 years (interquartile range, 42-68; range, 22-92 years) and 75 (54.3%) were men. |
TextSentencer_T17 |
1320-1490 |
Sentence |
denotes |
Hospital-associated transmission was suspected as the presumed mechanism of infection for affected health professionals (40 [29%]) and hospitalized patients (17 [12.3%]). |
TextSentencer_T18 |
1491-1586 |
Sentence |
denotes |
Common symptoms included fever (136 [98.6%]), fatigue (96 [69.6%]), and dry cough (82 [59.4%]). |
TextSentencer_T19 |
1587-1865 |
Sentence |
denotes |
Lymphopenia (lymphocyte count, 0.8 × 109/L [interquartile range {IQR}, 0.6-1.1]) occurred in 97 patients (70.3%), prolonged prothrombin time (13.0 seconds [IQR, 12.3-13.7]) in 80 patients (58%), and elevated lactate dehydrogenase (261 U/L [IQR, 182-403]) in 55 patients (39.9%). |
TextSentencer_T20 |
1866-1984 |
Sentence |
denotes |
Chest computed tomographic scans showed bilateral patchy shadows or ground glass opacity in the lungs of all patients. |
TextSentencer_T21 |
1985-2212 |
Sentence |
denotes |
Most patients received antiviral therapy (oseltamivir, 124 [89.9%]), and many received antibacterial therapy (moxifloxacin, 89 [64.4%]; ceftriaxone, 34 [24.6%]; azithromycin, 25 [18.1%]) and glucocorticoid therapy (62 [44.9%]). |
TextSentencer_T22 |
2213-2425 |
Sentence |
denotes |
Thirty-six patients (26.1%) were transferred to the intensive care unit (ICU) because of complications, including acute respiratory distress syndrome (22 [61.1%]), arrhythmia (16 [44.4%]), and shock (11 [30.6%]). |
TextSentencer_T23 |
2426-2547 |
Sentence |
denotes |
The median time from first symptom to dyspnea was 5.0 days, to hospital admission was 7.0 days, and to ARDS was 8.0 days. |
TextSentencer_T24 |
2548-2873 |
Sentence |
denotes |
Patients treated in the ICU (n = 36), compared with patients not treated in the ICU (n = 102), were older (median age, 66 years vs 51 years), were more likely to have underlying comorbidities (26 [72.2%] vs 38 [37.3%]), and were more likely to have dyspnea (23 [63.9%] vs 20 [19.6%]), and anorexia (24 [66.7%] vs 31 [30.4%]). |
TextSentencer_T25 |
2874-3094 |
Sentence |
denotes |
Of the 36 cases in the ICU, 4 (11.1%) received high-flow oxygen therapy, 15 (41.7%) received noninvasive ventilation, and 17 (47.2%) received invasive ventilation (4 were switched to extracorporeal membrane oxygenation). |
TextSentencer_T26 |
3095-3237 |
Sentence |
denotes |
As of February 3, 47 patients (34.1%) were discharged and 6 died (overall mortality, 4.3%), but the remaining patients are still hospitalized. |
TextSentencer_T27 |
3238-3330 |
Sentence |
denotes |
Among those discharged alive (n = 47), the median hospital stay was 10 days (IQR, 7.0-14.0). |
TextSentencer_T28 |
3331-3357 |
Sentence |
denotes |
Conclusions and Relevance: |
TextSentencer_T29 |
3358-3602 |
Sentence |
denotes |
In this single-center case series of 138 hospitalized patients with confirmed NCIP in Wuhan, China, presumed hospital-related transmission of 2019-nCoV was suspected in 41% of patients, 26% of patients received ICU care, and mortality was 4.3%. |