PubMed:32031570 JSONTXT 38 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-117 Sentence denotes Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
TextSentencer_T2 118-129 Sentence denotes Importance:
TextSentencer_T3 130-229 Sentence denotes In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China.
TextSentencer_T4 230-352 Sentence denotes The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
TextSentencer_T5 353-363 Sentence denotes Objective:
TextSentencer_T6 364-433 Sentence denotes To describe the epidemiological and clinical characteristics of NCIP.
TextSentencer_T7 434-468 Sentence denotes Design, Setting, and Participants:
TextSentencer_T8 469-714 Sentence denotes Retrospective, single-center case series of the 138 consecutive hospitalized patients with confirmed NCIP at Zhongnan Hospital of Wuhan University in Wuhan, China, from January 1 to January 28, 2020; final date of follow-up was February 3, 2020.
TextSentencer_T9 715-725 Sentence denotes Exposures:
TextSentencer_T10 726-742 Sentence denotes Documented NCIP.
TextSentencer_T11 743-770 Sentence denotes Main Outcomes and Measures:
TextSentencer_T12 771-884 Sentence denotes Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed.
TextSentencer_T13 885-966 Sentence denotes Outcomes of critically ill patients and noncritically ill patients were compared.
TextSentencer_T14 967-1168 Sentence denotes Presumed hospital-related transmission was suspected if a cluster of health professionals or hospitalized patients in the same wards became infected and a possible source of infection could be tracked.
TextSentencer_T15 1169-1177 Sentence denotes Results:
TextSentencer_T16 1178-1319 Sentence denotes Of 138 hospitalized patients with NCIP, the median age was 56 years (interquartile range, 42-68; range, 22-92 years) and 75 (54.3%) were men.
TextSentencer_T17 1320-1490 Sentence denotes Hospital-associated transmission was suspected as the presumed mechanism of infection for affected health professionals (40 [29%]) and hospitalized patients (17 [12.3%]).
TextSentencer_T18 1491-1586 Sentence denotes Common symptoms included fever (136 [98.6%]), fatigue (96 [69.6%]), and dry cough (82 [59.4%]).
TextSentencer_T19 1587-1865 Sentence denotes Lymphopenia (lymphocyte count, 0.8 × 109/L [interquartile range {IQR}, 0.6-1.1]) occurred in 97 patients (70.3%), prolonged prothrombin time (13.0 seconds [IQR, 12.3-13.7]) in 80 patients (58%), and elevated lactate dehydrogenase (261 U/L [IQR, 182-403]) in 55 patients (39.9%).
TextSentencer_T20 1866-1984 Sentence denotes Chest computed tomographic scans showed bilateral patchy shadows or ground glass opacity in the lungs of all patients.
TextSentencer_T21 1985-2212 Sentence denotes Most patients received antiviral therapy (oseltamivir, 124 [89.9%]), and many received antibacterial therapy (moxifloxacin, 89 [64.4%]; ceftriaxone, 34 [24.6%]; azithromycin, 25 [18.1%]) and glucocorticoid therapy (62 [44.9%]).
TextSentencer_T22 2213-2425 Sentence denotes Thirty-six patients (26.1%) were transferred to the intensive care unit (ICU) because of complications, including acute respiratory distress syndrome (22 [61.1%]), arrhythmia (16 [44.4%]), and shock (11 [30.6%]).
TextSentencer_T23 2426-2547 Sentence denotes The median time from first symptom to dyspnea was 5.0 days, to hospital admission was 7.0 days, and to ARDS was 8.0 days.
TextSentencer_T24 2548-2873 Sentence denotes Patients treated in the ICU (n = 36), compared with patients not treated in the ICU (n = 102), were older (median age, 66 years vs 51 years), were more likely to have underlying comorbidities (26 [72.2%] vs 38 [37.3%]), and were more likely to have dyspnea (23 [63.9%] vs 20 [19.6%]), and anorexia (24 [66.7%] vs 31 [30.4%]).
TextSentencer_T25 2874-3094 Sentence denotes Of the 36 cases in the ICU, 4 (11.1%) received high-flow oxygen therapy, 15 (41.7%) received noninvasive ventilation, and 17 (47.2%) received invasive ventilation (4 were switched to extracorporeal membrane oxygenation).
TextSentencer_T26 3095-3237 Sentence denotes As of February 3, 47 patients (34.1%) were discharged and 6 died (overall mortality, 4.3%), but the remaining patients are still hospitalized.
TextSentencer_T27 3238-3330 Sentence denotes Among those discharged alive (n = 47), the median hospital stay was 10 days (IQR, 7.0-14.0).
TextSentencer_T28 3331-3357 Sentence denotes Conclusions and Relevance:
TextSentencer_T29 3358-3602 Sentence denotes In this single-center case series of 138 hospitalized patients with confirmed NCIP in Wuhan, China, presumed hospital-related transmission of 2019-nCoV was suspected in 41% of patients, 26% of patients received ICU care, and mortality was 4.3%.