| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T394 |
0-117 |
Sentence |
denotes |
ACE2 shedding seems to be inducible by specific stimuli produced either by a viral infection or by the immune system. |
| T395 |
118-231 |
Sentence |
denotes |
Jia et al. (2009) confirmed ACE2 shedding in differentiated primary airway epithelial cells and Calu-3-cell line. |
| T396 |
232-440 |
Sentence |
denotes |
Furthermore, they demonstrated that the incubation with IL-1β at the dosage of 100 ng/ml and TNF α 100 ng/ml induced ACE2 shedding and sACE release, with a maximum after 18 h of incubation (Jia et al., 2009). |
| T397 |
441-576 |
Sentence |
denotes |
These findings suggest that an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection. |
| T398 |
577-761 |
Sentence |
denotes |
Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020). |
