LitCovid-sample-sentences  

PMC:7556165 / 2579-4653 JSONTXT 17 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T19 0-12 Sentence denotes Introduction
T20 13-191 Sentence denotes Angiotensin-converting enzyme (ACE) has an important role in the metabolism of several peptides and proteins, including chemical messengers, such as angiotensin I and bradykinin.
T21 192-465 Sentence denotes The importance assumed by research focused on ACE biochemistry, physiology and pharmacology is closely linked to the clinical effectiveness showed by ACE inhibitors in the treatment of cardiovascular disease, particularly arterial hypertension and congestive heart failure.
T22 466-546 Sentence denotes At present, ACE inhibitors are among the most widely prescribed drugs worldwide.
T23 547-618 Sentence denotes In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered.
T24 619-718 Sentence denotes It showed a different substrate selectively, and in particular it could not activate angiotensin I.
T25 719-785 Sentence denotes At the same time, it was not a target of classical ACE inhibitors.
T26 786-985 Sentence denotes Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced.
T27 986-1158 Sentence denotes In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2.
T28 1159-1373 Sentence denotes Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types.
T29 1374-1615 Sentence denotes Hypertension has been suggested to have a major impact on COVID-19 susceptibility and prognosis, therefore the elusive link between hypertension, anti-hypertensive drugs, and ACE2 expression has soon become the object of a major controversy.
T30 1616-1795 Sentence denotes On the other hand, treatments able to interfere with ACE2 expression, or ACE2 availability for SARS-CoV-2 binding, have been identified as a novel goal of pharmaceutical research.
T31 1796-1903 Sentence denotes The purpose of the present review is to summarize the available knowledge on ACE2 biochemistry and biology.
T32 1904-2074 Sentence denotes We have also tried to point out some crucial open questions, which should be addressed to provide a better background for future experimental and clinical investigations.