| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T125 |
0-140 |
Sentence |
denotes |
Detectable quantities of ACE2 protein have been found almost ubiquitously in tissues across mammalian species, using immunostaining methods. |
| T126 |
141-358 |
Sentence |
denotes |
ACE2 is predominantly located in the cardiovascular system and kidney, where it probably plays a role in the maintenance of hydro electrolyte homeostasis (section “Mechanism of Viral Entry Mediated by the S Protein”). |
| T127 |
359-577 |
Sentence |
denotes |
In fact, ACE2 is pervasively expressed throughout the vasculature, at the level of the arteries and veins, mainly in smooth muscle cells of the media and in the endothelium (Hamming et al., 2004; Burrell et al., 2005). |
| T128 |
578-668 |
Sentence |
denotes |
Such signal from vessels also delivers part of the expression detected in specific organs. |
| T129 |
669-1007 |
Sentence |
denotes |
Indeed, ACE2 is evident in: coronary vessels and myocardial capillaries (Wiener et al., 2007; Garabelli et al., 2008); lung microvascular endothelial cells (Wiener et al., 2007; Chen et al., 2013); kidney interlobular arteries (Lely et al., 2004); endothelial and smooth muscle cells in the brain (Hamming et al., 2004; Kar et al., 2010). |
| T130 |
1008-1185 |
Sentence |
denotes |
Notably, the mesangium and glomerular endothelium in the kidney, and the endothelial lining of the sinusoids in the liver are allegedly negative for ACE2 (Hamming et al., 2004). |
| T131 |
1186-1373 |
Sentence |
denotes |
On the contrary, ACE2 is virtually absent from the lymphatic system, and human hemato-lymphoid organs (i.e., spleen, lymph nodes, and bone marrow) (Hamming et al., 2004; Li et al., 2007). |
| T132 |
1374-1521 |
Sentence |
denotes |
In blood cells, it has been observed in platelets and macrophages, but not in B and T lymphocytes (Hamming et al., 2004; Fraga-Silva et al., 2011). |
