| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T112 |
0-215 |
Sentence |
denotes |
Beside undergoing post-translational modifications by glycosylation and phosphorylation, ACE2 is also post-translationally regulated by shedding from cell membrane through the action of the metalloproteinase ADAM17. |
| T113 |
216-386 |
Sentence |
denotes |
The proteolysis of ACE2 releases a soluble, enzymatically active form which corresponds to the ACE2 ectodomain (Jia et al., 2009; Xiao et al., 2014; Conrad et al., 2016). |
| T114 |
387-504 |
Sentence |
denotes |
The function, if any, of soluble ACE2 is still obscure, but the shedding mechanism is under strict molecular control. |
| T115 |
505-667 |
Sentence |
denotes |
Lambert et al. (2008) highlighted that calmodulin associates with ACE2 to prevent its shedding, while calmodulin inhibitors increase the cellular release of ACE2. |
| T116 |
668-717 |
Sentence |
denotes |
Patel identified a positive feedback in the RAAS: |
| T117 |
718-828 |
Sentence |
denotes |
Ang II activates ADAM17, thereby increasing the release of ACE2, its negative regulator (Patel et al., 2016b). |
| T118 |
829-960 |
Sentence |
denotes |
It is worth noting that high levels of plasma-soluble ACE2 have been associated with myocardial dysfunction (Epelman et al., 2009). |
| T119 |
961-1092 |
Sentence |
denotes |
The potential pathophysiological role of ADAM17 is further discussed in paragraph ACE2 and the Inflammatory Response to Sars-CoV-2. |
