LitCovid-sample-sentences  

PMC:7443692 / 31015-32563 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T184 0-125 Sentence denotes We integrated our glycomics, glycoproteomics, and population variant analyses results with a 3D model of Ace 2 (based on PDB:
T185 126-275 Sentence denotes 6M0J (Lan et al., 2020; see STAR Methods for details) to generate two versions of the soluble glycosylated ACE2 for visualization and MD simulations.
T186 276-494 Sentence denotes We visualized the ACE2 glycoprotein with the Abundance glycoform model simulated at each site as well as highlighting the naturally occurring variants observed in the human population (Figure 6 A; Video S2; Table S11).
T187 495-615 Sentence denotes Note, that the Abundance glycoform model and the Oxford Class glycoform model for ACE2 are identical (Tables S1 and S8).
T188 616-803 Sentence denotes Notably, one site of N-linked glycosylation (N546) is predicted to not be present in three out of 10,000 humans based on naturally occurring variation in the human population (Table S11).
T189 804-873 Sentence denotes We also modeled ACE2 using the Processed glycoform model (Figure 6B).
T190 874-961 Sentence denotes In both models, the interaction domain with S is defined (Figures 6A and 6B; Video S2).
T191 962-1028 Sentence denotes Figure 6 3D Structural Modeling of Glycosylated Soluble Human ACE2
T192 1029-1210 Sentence denotes Results from glycomics and glycoproteomics experiments were combined with results from bioinformatics analyses and used to model several versions of glycosylated soluble human ACE2.
T193 1211-1343 Sentence denotes (A) Soluble human ACE2 model from MD simulations displaying abundance glycoforms, interaction surface with S, and sequence variants.
T194 1344-1435 Sentence denotes N546 variant is boxed that would remove N-linked glycosylation at that site (see Video S2).
T195 1436-1548 Sentence denotes (B) Soluble human ACE2 model from MD simulations displaying processed glycoforms and interaction surface with S.