| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T72 |
0-285 |
Sentence |
denotes |
In addition to protein membrane receptors, infection of host cells by HCoVs also relies on sialic acid-containing glycoproteins and gangliosides, which are used by a broad range of viruses as receptors, such as influenza [20] and HCoVs including SARS-CoV [21] and HCoV-OC43 [13,22,23]. |
| T73 |
286-484 |
Sentence |
denotes |
A recent molecular structure analysis showed that SARS-CoV-2 not only uses ACE2 as a receptor, but also recognizes highly conserved gangliosides on the host cell surface through sialic acid [24,25]. |
| T74 |
485-625 |
Sentence |
denotes |
CQ/HCQ binds sialic acids and gangliosides with high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25]. |
| T75 |
626-733 |
Sentence |
denotes |
CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27]. |
| T76 |
734-885 |
Sentence |
denotes |
Hence, the mechanism of anti-CoV activity of CQ/HCQ may also be related to hindering the recognition process of sialic acid and ganglioside (Figure 1). |
