LitCovid-sample-sentences  

PMC:7441788 / 28509-34097 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T201 0-146 Sentence denotes There are also several reports that investigated the efficacy of CQ or HCQ in combination with a macrolide in the treatment of COVID-19 (Table 1).
T202 147-330 Sentence denotes In an open nonrandom clinical trial conducted in France [57], of the 36 participants, 20 patients were given HCQ (200 mg/3 times) with 6 receiving added azithromycin, and 16 controls.
T203 331-495 Sentence denotes The results showed that compared with the control group, HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days.
T204 496-665 Sentence denotes On the 6th day after treatment, the virus clearance rates of HCQ combined with azithromycin, HCQ alone and controls were 100%, 57.1% and 12.5%, respectively (P < 0.001).
T205 666-778 Sentence denotes This study indicated that the combined application of azithromycin and HCQ appears to have a synergistic effect.
T206 779-988 Sentence denotes However, the trial design and the results were unreliable, as six patients in the HCQ group discontinued treatment early due to critical illness or intolerance to the drugs and were excluded from the analysis.
T207 989-1072 Sentence denotes The assessment of efficacy was based on viral load rather than a clinical endpoint.
T208 1073-1418 Sentence denotes An observational study in 80 COVID-19 patients evaluated the efficacy of HCQ (200 mg/3 times/day for 10 days) in combination with azithromycin (500 mg on the first day, 250 mg/day afterward for 5 days) and showed that all patients’ clinical symptoms were improved, except for one patient aged over 86 years who died due to critical illness [58].
T209 1419-1591 Sentence denotes The nasopharynx viral load in most patients decreased rapidly, and the negative rates of viral nucleic acid conversion on days 7 and 8 were about 83% and 93%, respectively.
T210 1592-1685 Sentence denotes About 97.5% of patients had negative virus culture in respiratory specimens on the fifth day.
T211 1686-1778 Sentence denotes However, this study had no control group, thus the results were difficult to interpret [58].
T212 1779-1883 Sentence denotes Some recent studies have yielded different results about the efficacy of HCQ combined with azithromycin.
T213 1884-2160 Sentence denotes A retrospective study including 368 patients (97 patients received HCQ, 113 patients received HCQ + azithromycin and 158 patients received no HCQ) from USA [59] showed that the rates of ventilation in the HCQ, HCQ+azithromycin and no HCQ groups had no significant differences.
T214 2161-2292 Sentence denotes Unfortunately, theHCQ group (but not in the HCQ+azithromycin group) had a higher risk of death from any case than the no HCQ group.
T215 2293-2463 Sentence denotes This study showed no evidence that the use of HCQ, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with COVID-19.
T216 2464-2578 Sentence denotes Noticeably, in patients treated with HCQ alone, an association with increased overall mortality was observed [59].
T217 2579-2706 Sentence denotes In this study, the subjects included were only men and most of them were black, which may affect the generality of the results.
T218 2707-2818 Sentence denotes In addition, the patients who received HCQ or azithromycin were more severe, which may also affect the results.
T219 2819-3106 Sentence denotes In a retrospective multicenter cohort study of a random sample of COVID-19 patients from 25 hospitals in New York [60], totaling 1438 patients, 735 received HCQ and azithromycin, 271 received HCQ alone, 211 received azithromycin alone and 221 received neither drug (HCQ or azithromycin).
T220 3107-3286 Sentence denotes The results showed that the hospital mortality rate of patients receiving HCQ＋azithromycin was 25.7%, HCQ alone was 19.9%, azithromycin alone was 10.0% and neither drug was 12.7%.
T221 3287-3517 Sentence denotes In adjusted Cox proportional hazards models, compared with patients receiving neither drug, there were no significant differences in hospital mortality rate for patients receiving HC＋azithromycin, HCQ alone, or azithromycin alone.
T222 3518-3632 Sentence denotes In this study, the sample size is large and includes patients with long-term, complex and ongoing hospitalization.
T223 3633-3823 Sentence denotes However, the mortality rate of this study was limited to in-hospital deaths, and patients discharged during the study period were considered alive, which may underestimate the morality rate.
T224 3824-4016 Sentence denotes Recently, a multinational registry analysis about HCQ or CQ with or without second-generation macrolides (especial azithromycin and clarithromycin) for treatment of COVID-19 was reported [61].
T225 4017-4072 Sentence denotes A total of 96,032 patients were included in this study.
T226 4073-4228 Sentence denotes Of these, 1868 received CQ, 3783 received CQ with a macrolide, 3016 received HCQ and 6221 received HCQ with a macrolide and 8114 patients as control group.
T227 4229-4561 Sentence denotes After controlling various confounding factors related to disease, when compared with the mortality in the control group (9.3%), CQ group was 16.4%, CQ with a macrolide group was 22.2%, HCQ group was 18.0% and HCQ group with a macrolide was 23.8%; each group was associated with an increased risk of hospital mortality independently.
T228 4562-4822 Sentence denotes Apart from this, compared with the control group (0.3%), CQ group (4.3%), CQ with a macrolide group (6.5%), HCQ group (6.1%) and HCQ with a macrolide group (8.1%) were independently associated with a risk for ventricular arrhythmia during hospitalization [61].
T229 4823-5012 Sentence denotes This study showed that CQ or HCQ (used alone or combination with a macrolide) was associated with an increased hazard for in-hospital death and an increased risk of ventricular arrhythmias.
T230 5013-5103 Sentence denotes This study included a large number of patients, but it is not a randomized clinical trial.
T231 5104-5321 Sentence denotes In short, some small studies have shown that HCQ combined with azithromycin could quickly and effectively eliminate viruses, but the design of these studies was flawed in many aspects, making the results unconvincing.
T232 5322-5588 Sentence denotes Several subsequent studies have shown that the combination of HCQ or CQ and macrolides (azithromycin or clarithromycin) has no obvious correlation with a reduced risk for mechanical ventilation, and may even increase the risk of arrhythmia and in-hospital mortality.