| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T86 |
0-6 |
Sentence |
denotes |
4.1.3. |
| T87 |
8-68 |
Sentence |
denotes |
Effects on cell signaling pathway and host defense machinery |
| T88 |
69-245 |
Sentence |
denotes |
The mitogen-activated protein kinase (MAPK) pathway transmits signals from the cell surface to the nucleus involved in the infection of CoVs such as MHV [36] and SARS-CoV [37]. |
| T89 |
246-385 |
Sentence |
denotes |
CQ could inhibit HCoV-229E replication in human embryonic lung epithelial cells (L132) through suppressing the activation of p38 MAPK [38]. |
| T90 |
386-551 |
Sentence |
denotes |
Moreover, HCQ could markedly induce the production of cellular reactive oxygen species (ROS), which play an important role in the activation of innate immunity [39]. |
| T91 |
552-709 |
Sentence |
denotes |
HCQ also could trigger the host defense mechanism through the mitochondrial antiviral signaling (MAVS) pathway, resulting in anti-dengue virus activity [39]. |
| T92 |
710-870 |
Sentence |
denotes |
Therefore, CQ/HCQ may also exert their antiviral activity by suppressing the activation of p38 MAPK pathway and affecting the host defense machinery (Figure 1). |
