Id |
Subject |
Object |
Predicate |
Lexical cue |
T120 |
0-189 |
Sentence |
denotes |
Viral envelope proteins are glycosylated to varying degrees, but depending on their overall mass, surface area, and volume, the overall density of glycan shielding may differ significantly. |
T121 |
190-286 |
Sentence |
denotes |
For example, both LASV GPC and coronavirus S proteins consist of 25% glycan by molecular weight. |
T122 |
287-594 |
Sentence |
denotes |
However, given the significantly larger protein surface area and volume of coronavirus S proteins, coverage of the glycan “shield” over the proteinaceous surface is considerably sparser in comparison to the smaller LASV GPC, which occludes a far greater proportion of the protein surface with fewer glycans. |
T123 |
595-855 |
Sentence |
denotes |
To demonstrate that the presence of glycosylation plays a major role in the immune response to these different glycoproteins, we studied the glycome of several biomedically important coronaviruses and compared their glycan compositions in a structural context. |