PMC:7228307 / 58420-58930 9 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T324 | 0-92 | Sentence | denotes | The role of FcγR in the action of these types of mAbs appears to be primarily as a scaffold. |
| T325 | 93-189 | Sentence | denotes | FcγRIIb is often the predominate receptor involved and the extent of its involvement is complex. |
| T326 | 190-510 | Sentence | denotes | In the case of CD40, the degree of FcγRIIb scaffolding potency is linked to the epitope location of the targeting mAb with greater potency seen for membrane proximal epitopes.43, 117 It is also noteworthy that depending on the epitope location, the scaffolding of anti‐CD40 mAbs may convert antagonist mAbs to agonistic. |