PMC:7228307 / 3968-4490 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T23 0-333 Sentence denotes In normal homeostatic immunity, there is a balance between IgG immune complex activation of proinflammatory responses through the activating‐type FcγRs—which leads to the destruction of opsonized pathogens—and of the modulation of these destructive effector responses by the inhibitory‐type FcγR, thereby avoiding injury to the host.
T24 334-522 Sentence denotes Thus, therapeutic mAbs powerfully exploit these opposing activities, making them versatile drugs whose therapeutic potency can be improved by specific engineering of Fc–FcγR interactions.7