| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T29 |
0-38 |
Sentence |
denotes |
2 SARS-CoV2 cell entry is not complex |
| T30 |
39-143 |
Sentence |
denotes |
Fig. 1 is a schematic illustration of the minimum proteins required to mediate the SARS-CoV2 cell entry. |
| T31 |
144-268 |
Sentence |
denotes |
The trimeric, transmembrane spike (S) glycoprotein of the virus, SARS-2-S, includes two main functional subunits: S1 and S2. |
| T32 |
269-423 |
Sentence |
denotes |
The former, in turn, consists of the four core domains, S1A, S1B, S1C, and S1D, that contribute to the attachment to the surface receptor of target cells. |
| T33 |
424-496 |
Sentence |
denotes |
Then, the latter coordinates the fusion of viral and cellular membranes. |
| T34 |
497-591 |
Sentence |
denotes |
Receptor binding activates proteases that can carry out proteolytic cleavage of the S protein. |
| T35 |
592-722 |
Sentence |
denotes |
In coronaviruses, cleavage occurs at two sites: the S1/S2 junction and at the S2′, a region close to the viral fusion peptide [2]. |
| T36 |
723-935 |
Sentence |
denotes |
Proteolytic cleavage of the S protein causes conformational changes so that they cannot revert to the original structure and profound enough to prime the S2 subunit for the fusion of viral and cellular membranes. |
| T37 |
936-990 |
Sentence |
denotes |
Fig. 1 Proteins required for the SARS-CoV2-cell entry. |
