PMC:7205724 / 2960-3950 JSONTXT 17 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T29 0-38 Sentence denotes 2 SARS-CoV2 cell entry is not complex
T30 39-143 Sentence denotes Fig. 1 is a schematic illustration of the minimum proteins required to mediate the SARS-CoV2 cell entry.
T31 144-268 Sentence denotes The trimeric, transmembrane spike (S) glycoprotein of the virus, SARS-2-S, includes two main functional subunits: S1 and S2.
T32 269-423 Sentence denotes The former, in turn, consists of the four core domains, S1A, S1B, S1C, and S1D, that contribute to the attachment to the surface receptor of target cells.
T33 424-496 Sentence denotes Then, the latter coordinates the fusion of viral and cellular membranes.
T34 497-591 Sentence denotes Receptor binding activates proteases that can carry out proteolytic cleavage of the S protein.
T35 592-722 Sentence denotes In coronaviruses, cleavage occurs at two sites: the S1/S2 junction and at the S2′, a region close to the viral fusion peptide [2].
T36 723-935 Sentence denotes Proteolytic cleavage of the S protein causes conformational changes so that they cannot revert to the original structure and profound enough to prime the S2 subunit for the fusion of viral and cellular membranes.
T37 936-990 Sentence denotes Fig. 1 Proteins required for the SARS-CoV2-cell entry.