| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T221 |
0-93 |
Sentence |
denotes |
The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. |
| T222 |
94-274 |
Sentence |
denotes |
The infection of human cells by SARS-CoV2 includes two sequential steps: attachment of the virus to the surface receptor of target cells and the fusion of viral and host membranes. |
| T223 |
275-453 |
Sentence |
denotes |
The former requires at least a receptor-binding domain on the SARS-CoV2 Spike protein that can interact with a cell surface receptor, for example, ACE2, expressed on human cells. |
| T224 |
454-655 |
Sentence |
denotes |
The latter requires at least the host protease(s) to mediate proteolytic cleavage of the SARS-CoV2 Spike protein into S1 and S2 subunits and consequently promote the fusion of viral and host membranes. |
| T225 |
656-902 |
Sentence |
denotes |
Also, SARS-CoV2 possesses a polybasic cleavage site that can explain the high pathogenicity of SARS-CoV2, N-glycans and O-glycans that make the dense decoration of SARS-CoV2 S protein, and cyclic regions that can interact with cell-surface GRP78. |
| T226 |
903-1085 |
Sentence |
denotes |
Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy. |
