LitCovid-sample-sentences  

PMC:7205724 / 23923-26102 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T196 0-15 Sentence denotes 7.2 Rationale:
T197 16-76 Sentence denotes Corticosteroids might help accelerate recovery from COVID-19
T198 77-247 Sentence denotes The study [30] investigated the effect of inhaled corticosteroids ciclesonide, cortisone, prednisolone, dexamethasone, and fluticasone on the replication of the MERS-CoV.
T199 248-339 Sentence denotes Among the four compounds, the only ciclesonide was capable of inhibiting viral replication.
T200 340-647 Sentence denotes Also, ciclesonide induced a significant inhibition of viral replication of other human coronaviruses, such as HCoV-229E and SARS-CoV, and another positive-strand RNA virus, rubella virus, while not affect the viral replication of negative-strand RNA viruses, e.g., influenza and respiratory syncytial virus.
T201 648-746 Sentence denotes For the MERS-CoV, a nonstructural protein 15 (NSP15) appeared to act as the target of ciclesonide.
T202 747-847 Sentence denotes An amino acid substitution in the NSP15 conferred resistance of the mutated MERS-CoV to ciclesonide.
T203 848-913 Sentence denotes Mometasone could help deal effectively with the mutated MERS-CoV.
T204 914-1041 Sentence denotes For the SARS-CoV2, all three ciclesonide, mometasone, and lopinavir were able to inhibit viral replication to a similar degree.
T205 1042-1199 Sentence denotes Interestingly, their effect was more noticeable than serine protease inhibitors, e.g., nafamostat and camostat in cells that Vero cells that express TMPRSS2.
T206 1200-1354 Sentence denotes It indicates the tendency of the SARS-CoV2 to enter the cell through the cathepsin/endosomal pathway rather than through the TMPRSS2/cell surface pathway.
T207 1355-1559 Sentence denotes The study [31] included 46 patients with severe COVID-19, of these 26 patients received methylprednisolone (1–2 mg/kg/d for 5–7 days), and 20 patients received standard therapy without methylprednisolone.
T208 1560-1706 Sentence denotes The first group achieved faster improvement in clinical symptoms (fever and peripheral oxygen saturation) and lung lesions detected by CT imaging.
T209 1707-1789 Sentence denotes However, two deaths occurred in the first group and one death in the second group.
T210 1790-1974 Sentence denotes Moreover, the two groups did not differ in laboratory parameters, including WBC, lymphocyte count, monocyte count, and cytokines (IL-2, IL-4, IL-6, and IL-10) six days after treatment.
T211 1975-2088 Sentence denotes There is a report of the patient with COVID-19 treated with methylprednisolone since day 8 of the disease course.
T212 2089-2179 Sentence denotes However, his situation worsened and developed respiratory failure and died on day 14 [32].