PMC:7205724 / 17405-19470 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T141 0-39 Sentence denotes 4.2 Intravenous immunoglobulins (IVIG)
T142 41-106 Sentence denotes 4.2.1 Hypothesis: IVIG contains a large pool of human antibodies
T143 107-294 Sentence denotes IVIG is an immunomodulatory treatment currently useful for a variety of human diseases that share an idiopathic origin, ranging from autoimmune disorders to primary antibody deficiencies.
T144 295-603 Sentence denotes Also, IVIG has shown promising results in case of severe (such as sepsis, Parvovirus B19 infection, West Nile virus encephalitis, HIV, Clostridium difficile infections, Mycobacterium avium, Mycobacterium tuberculosis, and Nocardia infections) and recurrent infections in primary antibodies deficiencies [21].
T145 604-723 Sentence denotes Most patients develop antibodies against the NP and RBD of 2019-nCoV during the second week after infection onset [22].
T146 724-919 Sentence denotes Analysis of serum samples collected 14 or more days after symptom onset revealed detection of IgG and IgM antibodies against NP in 94% and 88% and RBD in 100% and 94% among patients with COVID19.
T147 920-1045 Sentence denotes Studies consistently show that increased immunoglobulin levels accompany the transition from early to late course of COVID19.
T148 1046-1137 Sentence denotes It poses the possibility that IVIG therapy might help to accelerate recovery from COVID-19.
T149 1139-1221 Sentence denotes 4.2.2 Rationale: IVIG might help to improve the outcome of patients with COVID-19
T150 1222-1521 Sentence denotes The study [23] included ten patients with COVID-19 who demonstrated worsening symptoms, e.g., decreased lymphocyte count and decreased PaO2/FIO2 ratio and oxygen saturation, following treatment with a short-term moderate-dose corticosteroid (methylprednisolone 80 mg/d) plus immunoglobulin (10 g/d).
T151 1522-1701 Sentence denotes After switching to the double dose of 1600 mg/d methylprednisolone plus 20 g/d immunoglobulin, all of the patients improved in the clinical, laboratory, and paraclinical outcomes.
T152 1702-1833 Sentence denotes Passive immunization protects against disease, and so it should be administered as early as possible when the patient is diagnosed.
T153 1834-2065 Sentence denotes Studies show that the viral RNA of 2019-nCoV reaches its peak during the first week and then gradually decreases and that IgG and IgM begin to rise from the 10th day so that most patients have anti-viral antibodies by the 14th day.