Id |
Subject |
Object |
Predicate |
Lexical cue |
T3 |
0-151 |
Sentence |
denotes |
Vaccine development for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is focused on the trimeric spike protein that initiates infection. |
T4 |
152-215 |
Sentence |
denotes |
Each protomer in the trimeric spike has 22 glycosylation sites. |
T5 |
216-353 |
Sentence |
denotes |
How these sites are glycosylated may affect which cells the virus can infect and could shield some epitopes from antibody neutralization. |
T6 |
354-573 |
Sentence |
denotes |
Watanabe et al. expressed and purified recombinant glycosylated spike trimers, proteolysed them to yield glycopeptides containing a single glycan, and determined the composition of the glycan sites by mass spectrometry. |
T7 |
574-697 |
Sentence |
denotes |
The analysis provides a benchmark that can be used to measure antigen quality as vaccines and antibody tests are developed. |