| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T9810 |
0-8 |
NN |
denotes |
Sequence |
| T60681 |
9-24 |
NN |
denotes |
diversification |
| T14534 |
25-27 |
IN |
denotes |
of |
| T70071 |
28-31 |
NN |
denotes |
CoV |
| T46208 |
32-38 |
NNS |
denotes |
spikes |
| T65633 |
39-41 |
PRP |
denotes |
We |
| T71210 |
42-54 |
VBD |
denotes |
hypothesized |
| T65773 |
55-59 |
IN |
denotes |
that |
| T55109 |
60-78 |
JJ |
denotes |
solvent-accessible |
| T1585 |
78-79 |
-COMMA- |
denotes |
, |
| T39672 |
80-90 |
JJ |
denotes |
amino-acid |
| T20594 |
91-99 |
NNS |
denotes |
residues |
| T55010 |
100-102 |
IN |
denotes |
on |
| T92344 |
103-104 |
NN |
denotes |
S |
| T27449 |
105-113 |
NNS |
denotes |
proteins |
| T7753 |
114-119 |
MD |
denotes |
would |
| T87805 |
120-122 |
VB |
denotes |
be |
| T76109 |
123-133 |
VBG |
denotes |
undergoing |
| T49022 |
134-140 |
JJR |
denotes |
higher |
| T38215 |
141-146 |
NNS |
denotes |
rates |
| T48007 |
147-149 |
IN |
denotes |
of |
| T86087 |
150-159 |
NNS |
denotes |
mutations |
| T52952 |
160-168 |
VBN |
denotes |
compared |
| T99241 |
169-173 |
IN |
denotes |
with |
| T30950 |
174-180 |
JJ |
denotes |
buried |
| T25052 |
181-189 |
NNS |
denotes |
residues |
| T46492 |
190-193 |
CC |
denotes |
and |
| T57528 |
194-201 |
NNS |
denotes |
regions |
| T50177 |
202-206 |
WDT |
denotes |
that |
| T46892 |
207-210 |
VBP |
denotes |
are |
| T25102 |
211-219 |
VBN |
denotes |
occluded |
| T44481 |
220-222 |
IN |
denotes |
by |
| T18790 |
223-230 |
NNS |
denotes |
glycans |
| T48178 |
230-231 |
-COMMA- |
denotes |
, |
| T59110 |
232-237 |
WDT |
denotes |
which |
| T61432 |
238-241 |
VBP |
denotes |
are |
| T59632 |
242-248 |
JJ |
denotes |
unable |
| T87545 |
249-251 |
TO |
denotes |
to |
| T66630 |
252-254 |
VB |
denotes |
be |
| T30435 |
255-263 |
VBN |
denotes |
targeted |
| T87263 |
264-266 |
IN |
denotes |
by |
| T84547 |
267-271 |
NN |
denotes |
host |
| T42560 |
272-278 |
JJ |
denotes |
immune |
| T4934 |
279-288 |
NNS |
denotes |
responses |
| T73202 |
290-292 |
TO |
denotes |
To |
| T86654 |
293-297 |
DT |
denotes |
that |
| T62840 |
298-301 |
NN |
denotes |
end |
| T60967 |
301-302 |
-COMMA- |
denotes |
, |
| T58857 |
303-305 |
PRP |
denotes |
we |
| T3483 |
306-315 |
VBD |
denotes |
performed |
| T44308 |
316-318 |
DT |
denotes |
an |
| T42487 |
319-329 |
NN |
denotes |
evaluation |
| T38057 |
330-332 |
IN |
denotes |
of |
| T40313 |
333-343 |
JJ |
denotes |
amino-acid |
| T79756 |
344-359 |
NN |
denotes |
diversification |
| T74853 |
360-362 |
IN |
denotes |
on |
| T83914 |
363-364 |
DT |
denotes |
a |
| T53700 |
365-381 |
JJ |
denotes |
residue-specific |
| T63979 |
382-387 |
NN |
denotes |
level |
| T62380 |
387-388 |
-COMMA- |
denotes |
, |
| T6148 |
389-394 |
VBG |
denotes |
using |
| T77953 |
395-403 |
RB |
denotes |
publicly |
| T27779 |
404-413 |
JJ |
denotes |
available |
| T83161 |
414-418 |
NN |
denotes |
gene |
| T25304 |
419-428 |
NNS |
denotes |
sequences |
| T83245 |
429-431 |
IN |
denotes |
of |
| T52371 |
432-436 |
NNP |
denotes |
SARS |
| T61083 |
437-440 |
CC |
denotes |
and |
| T72419 |
441-445 |
NNP |
denotes |
MERS |
| T42372 |
446-447 |
NNP |
denotes |
S |
| T3167 |
447-448 |
-COMMA- |
denotes |
, |
| T70472 |
449-454 |
WDT |
denotes |
which |
| T16556 |
455-458 |
VBD |
denotes |
was |
| T69286 |
459-469 |
VBN |
denotes |
calculated |
| T52989 |
470-472 |
IN |
denotes |
as |
| T29326 |
473-476 |
DT |
denotes |
the |
| T41479 |
477-483 |
NN |
denotes |
number |
| T1834 |
484-486 |
IN |
denotes |
of |
| T51205 |
487-495 |
VBN |
denotes |
observed |
| T91746 |
496-504 |
JJ |
denotes |
pairwise |
| T46357 |
505-516 |
NNS |
denotes |
differences |
| T17558 |
517-524 |
VBN |
denotes |
divided |
| T41351 |
525-527 |
IN |
denotes |
by |
| T50799 |
528-531 |
DT |
denotes |
the |
| T28579 |
532-537 |
JJ |
denotes |
total |
| T58945 |
538-544 |
NN |
denotes |
number |
| T84292 |
545-547 |
IN |
denotes |
of |
| T34101 |
548-556 |
JJ |
denotes |
pairwise |
| T94055 |
557-568 |
NNS |
denotes |
comparisons |
| T18701 |
570-577 |
RB |
denotes |
Firstly |
| T74266 |
577-578 |
-COMMA- |
denotes |
, |
| T36827 |
579-581 |
PRP |
denotes |
we |
| T39186 |
582-587 |
VBD |
denotes |
found |
| T6773 |
588-592 |
IN |
denotes |
that |
| T13224 |
593-603 |
JJ |
denotes |
amino-acid |
| T54008 |
604-613 |
NN |
denotes |
diversity |
| T35302 |
614-617 |
VBD |
denotes |
was |
| T93591 |
618-626 |
VBN |
denotes |
elevated |
| T90961 |
627-629 |
IN |
denotes |
at |
| T69090 |
630-635 |
VBN |
denotes |
known |
| T86793 |
636-644 |
NNS |
denotes |
epitopes |
| T61088 |
645-653 |
VBN |
denotes |
targeted |
| T53019 |
654-656 |
IN |
denotes |
by |
| T30461 |
657-669 |
VBG |
denotes |
neutralizing |
| T32200 |
670-680 |
NNS |
denotes |
antibodies |
| T83554 |
680-681 |
-COMMA- |
denotes |
, |
| T32640 |
682-686 |
JJ |
denotes |
such |
| T51281 |
687-689 |
IN |
denotes |
as |
| T69890 |
690-693 |
DT |
denotes |
the |
| T83248 |
694-704 |
JJ |
denotes |
N-terminal |
| T49099 |
705-711 |
NN |
denotes |
domain |
| T58919 |
712-715 |
CC |
denotes |
and |
| T18721 |
716-719 |
DT |
denotes |
the |
| T18570 |
720-736 |
JJ |
denotes |
receptor-binding |
| T60790 |
737-744 |
NNS |
denotes |
domains |
| T18812 |
744-745 |
-COMMA- |
denotes |
, |
| T96660 |
746-749 |
CC |
denotes |
and |
| T11216 |
750-757 |
VBN |
denotes |
reduced |
| T27277 |
758-760 |
IN |
denotes |
in |
| T89562 |
761-764 |
DT |
denotes |
the |
| T7777 |
765-772 |
NNS |
denotes |
regions |
| T23472 |
773-775 |
IN |
denotes |
in |
| T66095 |
776-779 |
DT |
denotes |
the |
| T52990 |
780-782 |
NN |
denotes |
S2 |
| T69246 |
783-789 |
NN |
denotes |
domain |
| T76095 |
789-790 |
-COMMA- |
denotes |
, |
| T33023 |
791-795 |
JJ |
denotes |
such |
| T94778 |
796-798 |
IN |
denotes |
as |
| T12698 |
799-802 |
DT |
denotes |
the |
| T82633 |
803-809 |
NN |
denotes |
fusion |
| T75213 |
810-817 |
NN |
denotes |
peptide |
| T29294 |
817-818 |
-COMMA- |
denotes |
, |
| T28968 |
819-825 |
NN |
denotes |
heptad |
| T29760 |
826-832 |
NN |
denotes |
repeat |
| T53742 |
833-836 |
CD |
denotes |
one |
| T18725 |
836-837 |
-COMMA- |
denotes |
, |
| T43420 |
838-841 |
CC |
denotes |
and |
| T34460 |
842-845 |
DT |
denotes |
the |
| T26621 |
846-853 |
JJ |
denotes |
central |
| T91466 |
854-859 |
NN |
denotes |
helix |
| T93319 |
860-867 |
NNS |
denotes |
domains |
| T88231 |
867-868 |
-COMMA- |
denotes |
, |
| T49934 |
869-874 |
WDT |
denotes |
which |
| T23715 |
875-878 |
VBP |
denotes |
are |
| T33407 |
879-885 |
RB |
denotes |
likely |
| T88882 |
886-893 |
JJ |
denotes |
subject |
| T76117 |
894-896 |
TO |
denotes |
to |
| T4874 |
897-904 |
JJR |
denotes |
greater |
| T38302 |
905-915 |
JJ |
denotes |
functional |
| T99472 |
916-927 |
NNS |
denotes |
constraints |
| T34520 |
928-929 |
-LRB- |
denotes |
( |
| T48991 |
929-936 |
NN |
denotes |
Fig. 4a |
| T5319 |
936-937 |
-RRB- |
denotes |
) |
| T69499 |
939-947 |
NN |
denotes |
Analysis |
| T65163 |
948-950 |
IN |
denotes |
of |
| T23395 |
951-954 |
DT |
denotes |
the |
| T78947 |
955-963 |
JJ |
denotes |
relative |
| T61369 |
964-969 |
NN |
denotes |
ratio |
| T85886 |
970-972 |
IN |
denotes |
of |
| T53309 |
973-987 |
JJ |
denotes |
non-synonymous |
| T78726 |
988-990 |
TO |
denotes |
to |
| T13118 |
991-1001 |
JJ |
denotes |
synonymous |
| T63573 |
1002-1012 |
NN |
denotes |
nucleotide |
| T72369 |
1013-1026 |
NNS |
denotes |
substitutions |
| T18378 |
1027-1028 |
-LRB- |
denotes |
( |
| T58404 |
1028-1032 |
FW |
denotes |
i.e. |
| T58779 |
1033-1038 |
NN |
denotes |
dN/dS |
| T10324 |
1039-1045 |
NNS |
denotes |
ratios |
| T30580 |
1045-1046 |
-RRB- |
denotes |
) |
| T83087 |
1047-1055 |
VBD |
denotes |
revealed |
| T2494 |
1056-1060 |
IN |
denotes |
that |
| T4328 |
1061-1068 |
VBN |
denotes |
exposed |
| T12652 |
1069-1077 |
NNS |
denotes |
residues |
| T92287 |
1078-1087 |
VBD |
denotes |
exhibited |
| T88501 |
1088-1101 |
RB |
denotes |
significantly |
| T11718 |
1102-1108 |
JJR |
denotes |
higher |
| T86795 |
1109-1114 |
NN |
denotes |
dN/dS |
| T59603 |
1115-1121 |
NNS |
denotes |
values |
| T7211 |
1122-1123 |
-LRB- |
denotes |
( |
| T4769 |
1123-1130 |
NN |
denotes |
Fig. 4b |
| T47239 |
1130-1131 |
-RRB- |
denotes |
) |
| T90969 |
1133-1139 |
VBN |
denotes |
Buried |
| T92849 |
1140-1148 |
NNS |
denotes |
residues |
| T78244 |
1149-1151 |
IN |
denotes |
on |
| T54331 |
1152-1156 |
NNS |
denotes |
SARS |
| T42940 |
1157-1160 |
VBD |
denotes |
had |
| T56294 |
1161-1165 |
JJ |
denotes |
mean |
| T46802 |
1166-1171 |
NN |
denotes |
dN/dS |
| T64331 |
1172-1178 |
NNS |
denotes |
ratios |
| T35591 |
1179-1181 |
IN |
denotes |
of |
| T4586 |
1182-1186 |
CD |
denotes |
0.31 |
| T68155 |
1187-1195 |
VBN |
denotes |
compared |
| T78948 |
1196-1200 |
IN |
denotes |
with |
| T78585 |
1201-1205 |
CD |
denotes |
2.82 |
| T27968 |
1206-1209 |
IN |
denotes |
for |
| T96310 |
1210-1217 |
VBN |
denotes |
exposed |
| T43288 |
1218-1225 |
NNS |
denotes |
resides |
| T92960 |
1227-1235 |
RB |
denotes |
Likewise |
| T14475 |
1235-1236 |
-COMMA- |
denotes |
, |
| T32298 |
1237-1240 |
DT |
denotes |
the |
| T12634 |
1241-1247 |
VBN |
denotes |
buried |
| T80500 |
1248-1256 |
NNS |
denotes |
residues |
| T77635 |
1257-1259 |
IN |
denotes |
on |
| T24392 |
1260-1264 |
NNS |
denotes |
MERS |
| T2961 |
1265-1268 |
VBD |
denotes |
had |
| T6521 |
1269-1270 |
DT |
denotes |
a |
| T8471 |
1271-1281 |
VBN |
denotes |
calculated |
| T37460 |
1282-1287 |
NN |
denotes |
dN/dS |
| T55408 |
1288-1293 |
NN |
denotes |
ratio |
| T45120 |
1294-1296 |
IN |
denotes |
of |
| T23381 |
1297-1301 |
CD |
denotes |
0.10 |
| T30445 |
1302-1310 |
VBN |
denotes |
compared |
| T55016 |
1311-1315 |
IN |
denotes |
with |
| T1385 |
1316-1323 |
VBN |
denotes |
exposed |
| T65828 |
1324-1332 |
NNS |
denotes |
residues |
| T35353 |
1333-1337 |
IN |
denotes |
with |
| T91154 |
1338-1339 |
DT |
denotes |
a |
| T26380 |
1340-1345 |
NN |
denotes |
value |
| T92544 |
1346-1348 |
IN |
denotes |
of |
| T79406 |
1349-1353 |
CD |
denotes |
0.45 |
| T92418 |
1355-1366 |
RB |
denotes |
Furthermore |
| T91452 |
1366-1367 |
-COMMA- |
denotes |
, |
| T84302 |
1368-1372 |
WRB |
denotes |
when |
| T74584 |
1373-1381 |
JJ |
denotes |
per-site |
| T76352 |
1382-1392 |
JJ |
denotes |
amino-acid |
| T98451 |
1393-1404 |
NNS |
denotes |
diversities |
| T72837 |
1405-1409 |
VBD |
denotes |
were |
| T54724 |
1410-1416 |
VBN |
denotes |
mapped |
| T45778 |
1417-1421 |
IN |
denotes |
onto |
| T98923 |
1422-1425 |
DT |
denotes |
the |
| T59533 |
1426-1431 |
RB |
denotes |
fully |
| T25862 |
1432-1444 |
VBN |
denotes |
glycosylated |
| T32515 |
1445-1455 |
JJ |
denotes |
structural |
| T94405 |
1456-1461 |
NN |
denotes |
model |
| T76643 |
1462-1464 |
IN |
denotes |
of |
| T13755 |
1465-1468 |
DT |
denotes |
the |
| T14482 |
1469-1479 |
JJ |
denotes |
respective |
| T65032 |
1480-1483 |
NN |
denotes |
CoV |
| T12704 |
1484-1485 |
NN |
denotes |
S |
| T70323 |
1486-1494 |
NNS |
denotes |
proteins |
| T33888 |
1495-1496 |
-LRB- |
denotes |
( |
| T60190 |
1496-1503 |
NN |
denotes |
Fig. 4c |
| T27628 |
1503-1504 |
-RRB- |
denotes |
) |
| T87038 |
1504-1505 |
-COMMA- |
denotes |
, |
| T49843 |
1506-1514 |
NNS |
denotes |
hotspots |
| T77547 |
1515-1517 |
IN |
denotes |
of |
| T63244 |
1518-1527 |
NNS |
denotes |
mutations |
| T5765 |
1528-1532 |
VBD |
denotes |
were |
| T8574 |
1533-1544 |
VBN |
denotes |
highlighted |
| T21020 |
1545-1547 |
IN |
denotes |
on |
| T89986 |
1548-1551 |
DT |
denotes |
the |
| T65568 |
1552-1559 |
NN |
denotes |
protein |
| T63130 |
1560-1567 |
NN |
denotes |
surface |
| T96535 |
1568-1578 |
IN |
denotes |
throughout |
| T21467 |
1579-1582 |
DT |
denotes |
the |
| T66745 |
1583-1589 |
NN |
denotes |
trimer |
| T45284 |
1590-1599 |
VBG |
denotes |
revealing |
| T17381 |
1600-1609 |
JJ |
denotes |
extensive |
| T55156 |
1610-1625 |
NNS |
denotes |
vulnerabilities |
| T13067 |
1626-1636 |
VBG |
denotes |
permeating |
| T40910 |
1637-1644 |
IN |
denotes |
through |
| T14483 |
1645-1648 |
DT |
denotes |
the |
| T29556 |
1649-1655 |
NN |
denotes |
glycan |
| T94871 |
1656-1662 |
NN |
denotes |
shield |
| T71413 |
1663-1665 |
IN |
denotes |
of |
| T81413 |
1666-1670 |
NNS |
denotes |
SARS |
| T68523 |
1671-1674 |
CC |
denotes |
and |
| T70297 |
1675-1679 |
NNP |
denotes |
MERS |
| T12679 |
1680-1684 |
NNP |
denotes |
CoVs |
| T87216 |
1686-1688 |
PRP |
denotes |
It |
| T15902 |
1689-1691 |
VBZ |
denotes |
is |
| T6523 |
1692-1703 |
JJ |
denotes |
interesting |
| T19232 |
1704-1706 |
TO |
denotes |
to |
| T97839 |
1707-1711 |
VB |
denotes |
note |
| T99309 |
1712-1715 |
DT |
denotes |
the |
| T40498 |
1716-1720 |
NN |
denotes |
lack |
| T81866 |
1721-1723 |
IN |
denotes |
of |
| T9331 |
1724-1734 |
JJ |
denotes |
amino-acid |
| T44303 |
1735-1744 |
NN |
denotes |
diversity |
| T83531 |
1745-1747 |
IN |
denotes |
on |
| T76133 |
1748-1751 |
DT |
denotes |
the |
| T29918 |
1752-1768 |
JJ |
denotes |
receptor-binding |
| T15412 |
1769-1776 |
NNS |
denotes |
domains |
| T38048 |
1777-1779 |
IN |
denotes |
of |
| T48648 |
1780-1784 |
NNS |
denotes |
MERS |
| T31354 |
1785-1786 |
NN |
denotes |
S |
| T92070 |
1787-1795 |
NNS |
denotes |
proteins |
| T5507 |
1796-1800 |
WDT |
denotes |
that |
| T19099 |
1801-1809 |
VBP |
denotes |
protrude |
| T77842 |
1810-1814 |
RB |
denotes |
away |
| T99218 |
1815-1819 |
IN |
denotes |
from |
| T68020 |
1820-1823 |
DT |
denotes |
the |
| T87267 |
1824-1831 |
NNS |
denotes |
glycans |
| T55216 |
1833-1835 |
PRP |
denotes |
We |
| T15548 |
1836-1841 |
MD |
denotes |
would |
| T19328 |
1842-1849 |
VB |
denotes |
suggest |
| T73414 |
1850-1854 |
IN |
denotes |
that |
| T39503 |
1855-1859 |
DT |
denotes |
this |
| T1176 |
1860-1863 |
MD |
denotes |
may |
| T73192 |
1864-1870 |
VB |
denotes |
result |
| T18164 |
1871-1875 |
IN |
denotes |
from |
| T59646 |
1876-1879 |
DT |
denotes |
the |
| T56626 |
1880-1889 |
JJ |
denotes |
intrinsic |
| T77011 |
1890-1906 |
JJ |
denotes |
receptor-binding |
| T13068 |
1907-1920 |
NN |
denotes |
functionality |
| T25400 |
1921-1923 |
IN |
denotes |
of |
| T95940 |
1924-1929 |
DT |
denotes |
these |
| T4558 |
1930-1937 |
NNS |
denotes |
domains |
| T85225 |
1939-1947 |
IN |
denotes |
Although |
| T78299 |
1948-1953 |
NN |
denotes |
dN/dS |
| T69491 |
1954-1963 |
NNS |
denotes |
estimates |
| T17336 |
1964-1967 |
VBP |
denotes |
are |
| T68738 |
1968-1978 |
JJ |
denotes |
comparable |
| T29834 |
1979-1985 |
IN |
denotes |
within |
| T7384 |
1986-1990 |
DT |
denotes |
each |
| T38180 |
1991-1996 |
JJ |
denotes |
viral |
| T14361 |
1997-2005 |
NN |
denotes |
outbreak |
| T27804 |
2005-2006 |
-COMMA- |
denotes |
, |
| T63927 |
2007-2011 |
PRP |
denotes |
they |
| T40801 |
2012-2015 |
VBP |
denotes |
are |
| T50374 |
2016-2019 |
RB |
denotes |
not |
| T5187 |
2020-2028 |
RB |
denotes |
directly |
| T67674 |
2029-2039 |
JJ |
denotes |
comparable |
| T16791 |
2040-2047 |
IN |
denotes |
between |
| T15216 |
2048-2053 |
JJ |
denotes |
viral |
| T70745 |
2054-2062 |
NNS |
denotes |
families |
| T5519 |
2063-2065 |
IN |
denotes |
as |
| T39713 |
2066-2070 |
PRP |
denotes |
they |
| T72942 |
2071-2074 |
MD |
denotes |
can |
| T66143 |
2075-2079 |
RB |
denotes |
only |
| T83434 |
2080-2082 |
VB |
denotes |
be |
| T81231 |
2083-2093 |
VBN |
denotes |
considered |
| T66257 |
2094-2096 |
IN |
denotes |
in |
| T26996 |
2097-2100 |
DT |
denotes |
the |
| T12587 |
2101-2112 |
NN |
denotes |
environment |
| T55529 |
2113-2115 |
IN |
denotes |
in |
| T94028 |
2116-2121 |
WDT |
denotes |
which |
| T66921 |
2122-2126 |
PRP |
denotes |
they |
| T48812 |
2127-2130 |
VBP |
denotes |
are |
| T68204 |
2131-2139 |
VBN |
denotes |
measured |
| T1345 |
2140-2141 |
-LRB- |
denotes |
( |
| T50152 |
2141-2145 |
FW |
denotes |
i.e. |
| T58234 |
2146-2154 |
JJ |
denotes |
multiple |
| T20304 |
2155-2166 |
NNS |
denotes |
differences |
| T57102 |
2167-2169 |
IN |
denotes |
in |
| T44931 |
2170-2182 |
NN |
denotes |
transmission |
| T48849 |
2183-2190 |
NN |
denotes |
ecology |
| T40406 |
2191-2194 |
CC |
denotes |
and |
| T86262 |
2195-2205 |
NN |
denotes |
host-virus |
| T60225 |
2206-2218 |
NNS |
denotes |
interactions |
| T28690 |
2219-2227 |
VBP |
denotes |
disallow |
| T4001 |
2228-2238 |
JJ |
denotes |
meaningful |
| T97622 |
2239-2250 |
NNS |
denotes |
comparisons |
| T88580 |
2250-2251 |
-RRB- |
denotes |
) |
| T61778 |
2253-2256 |
IN |
denotes |
For |
| T80559 |
2257-2264 |
NN |
denotes |
example |
| T85630 |
2264-2265 |
-COMMA- |
denotes |
, |
| T13499 |
2266-2277 |
NNS |
denotes |
differences |
| T59995 |
2278-2280 |
IN |
denotes |
in |
| T19712 |
2281-2284 |
DT |
denotes |
the |
| T30994 |
2285-2293 |
JJ |
denotes |
epidemic |
| T28935 |
2294-2303 |
NN |
denotes |
behaviour |
| T90583 |
2304-2307 |
CC |
denotes |
and |
| T22228 |
2308-2312 |
NN |
denotes |
host |
| T48983 |
2313-2319 |
JJ |
denotes |
immune |
| T32345 |
2320-2331 |
NN |
denotes |
environment |
| T33520 |
2332-2334 |
IN |
denotes |
of |
| T49936 |
2335-2339 |
NNS |
denotes |
MERS |
| T62735 |
2340-2343 |
CC |
denotes |
and |
| T19591 |
2344-2348 |
NNP |
denotes |
SARS |
| T85021 |
2349-2358 |
NNS |
denotes |
outbreaks |
| T32139 |
2359-2365 |
RB |
denotes |
likely |
| T6621 |
2366-2376 |
VBP |
denotes |
contribute |
| T58427 |
2377-2379 |
TO |
denotes |
to |
| T13399 |
2380-2383 |
DT |
denotes |
the |
| T26807 |
2384-2392 |
VBN |
denotes |
observed |
| T13552 |
2393-2400 |
JJ |
denotes |
genetic |
| T43199 |
2401-2410 |
NN |
denotes |
diversity |
| T65839 |
2411-2414 |
CC |
denotes |
and |
| T79458 |
2415-2419 |
RB |
denotes |
thus |
| T98636 |
2420-2425 |
NN |
denotes |
dN/dS |
| T25443 |
2427-2431 |
NNS |
denotes |
MERS |
| T97762 |
2432-2435 |
VBD |
denotes |
was |
| T89667 |
2436-2449 |
VBN |
denotes |
characterized |
| T47196 |
2450-2452 |
IN |
denotes |
by |
| T18635 |
2453-2461 |
VBN |
denotes |
repeated |
| T30054 |
2462-2471 |
NN |
denotes |
spillover |
| T27860 |
2472-2478 |
NNS |
denotes |
events |
| T14782 |
2479-2483 |
IN |
denotes |
from |
| T25019 |
2484-2490 |
NNS |
denotes |
camels |
| T86652 |
2491-2495 |
IN |
denotes |
into |
| T1639 |
2496-2502 |
NNS |
denotes |
humans |
| T23535 |
2502-2503 |
-COMMA- |
denotes |
, |
| T51241 |
2504-2509 |
WRB |
denotes |
where |
| T67194 |
2510-2512 |
PRP |
denotes |
it |
| T59854 |
2513-2523 |
VBD |
denotes |
circulated |
| T82528 |
2524-2535 |
RB |
denotes |
transiently |
| T23126 |
2537-2539 |
IN |
denotes |
In |
| T4625 |
2540-2548 |
NN |
denotes |
contrast |
| T47309 |
2548-2549 |
-COMMA- |
denotes |
, |
| T1278 |
2550-2553 |
DT |
denotes |
the |
| T1279 |
2554-2558 |
NNP |
denotes |
SARS |
| T1280 |
2559-2567 |
NN |
denotes |
outbreak |
| T1281 |
2568-2580 |
VBD |
denotes |
corresponded |
| T1282 |
2581-2583 |
TO |
denotes |
to |
| T1283 |
2584-2585 |
DT |
denotes |
a |
| T1284 |
2586-2592 |
JJ |
denotes |
single |
| T1285 |
2593-2601 |
JJ |
denotes |
zoonotic |
| T1286 |
2602-2607 |
NN |
denotes |
event |
| T1287 |
2608-2616 |
VBN |
denotes |
followed |
| T1288 |
2617-2619 |
IN |
denotes |
by |
| T1289 |
2620-2629 |
JJ |
denotes |
extensive |
| T1290 |
2630-2644 |
JJ |
denotes |
human-to-human |
| T1291 |
2645-2657 |
NN |
denotes |
transmission |
| T1292 |
2659-2671 |
RB |
denotes |
Consequently |
| T1293 |
2671-2672 |
-COMMA- |
denotes |
, |
| T1294 |
2673-2682 |
VBG |
denotes |
inferring |
| T1295 |
2683-2686 |
DT |
denotes |
the |
| T1296 |
2687-2693 |
NN |
denotes |
degree |
| T1297 |
2694-2696 |
IN |
denotes |
of |
| T1298 |
2697-2706 |
NN |
denotes |
selection |
| T1299 |
2707-2713 |
VBG |
denotes |
acting |
| T1300 |
2714-2718 |
IN |
denotes |
upon |
| T1301 |
2719-2723 |
NNS |
denotes |
MERS |
| T1302 |
2724-2727 |
CC |
denotes |
and |
| T1303 |
2728-2732 |
NNS |
denotes |
SARS |
| T1304 |
2733-2737 |
IN |
denotes |
from |
| T1305 |
2738-2743 |
NN |
denotes |
dN/dS |
| T1306 |
2744-2752 |
NN |
denotes |
analysis |
| T1307 |
2753-2755 |
VBZ |
denotes |
is |
| T1308 |
2756-2765 |
RB |
denotes |
extremely |
| T1309 |
2766-2775 |
JJ |
denotes |
difficult |
| T1310 |
2777-2788 |
RB |
denotes |
Importantly |
| T1311 |
2788-2789 |
-COMMA- |
denotes |
, |
| T1312 |
2790-2795 |
IN |
denotes |
while |
| T1313 |
2796-2803 |
JJ |
denotes |
similar |
| T1314 |
2804-2812 |
NNS |
denotes |
analyses |
| T1315 |
2813-2815 |
IN |
denotes |
of |
| T1316 |
2816-2826 |
NN |
denotes |
SARS-CoV-2 |
| T1317 |
2827-2829 |
VBZ |
denotes |
is |
| T1318 |
2830-2839 |
JJ |
denotes |
desirable |
| T1319 |
2839-2840 |
-COMMA- |
denotes |
, |
| T1320 |
2841-2844 |
JJ |
denotes |
due |
| T1321 |
2845-2847 |
TO |
denotes |
to |
| T1322 |
2848-2851 |
DT |
denotes |
the |
| T1323 |
2852-2855 |
JJ |
denotes |
low |
| T1324 |
2856-2863 |
JJ |
denotes |
genetic |
| T1325 |
2864-2873 |
NN |
denotes |
variation |
| T1326 |
2874-2879 |
IN |
denotes |
among |
| T1327 |
2880-2883 |
DT |
denotes |
the |
| T1328 |
2884-2891 |
JJ |
denotes |
current |
| T1329 |
2892-2902 |
NN |
denotes |
SARS-CoV-2 |
| T1330 |
2903-2912 |
NNS |
denotes |
sequences |
| T1331 |
2913-2914 |
-LRB- |
denotes |
( |
| T1332 |
2914-2916 |
IN |
denotes |
as |
| T1333 |
2917-2919 |
IN |
denotes |
of |
| T1334 |
2920-2922 |
CD |
denotes |
17 |
| T1335 |
2923-2928 |
NNP |
denotes |
March |
| T1336 |
2929-2933 |
CD |
denotes |
2020 |
| T1337 |
2933-2934 |
-RRB- |
denotes |
) |
| T1338 |
2934-2935 |
-COMMA- |
denotes |
, |
| T1339 |
2936-2941 |
WDT |
denotes |
which |
| T1340 |
2942-2948 |
RB |
denotes |
likely |
| T1341 |
2949-2956 |
VBP |
denotes |
include |
| T1342 |
2957-2968 |
JJ |
denotes |
deleterious |
| T1343 |
2969-2978 |
NNS |
denotes |
mutations |
| T1344 |
2979-2983 |
WDT |
denotes |
that |
| T79570 |
2984-2988 |
MD |
denotes |
will |
| T1346 |
2989-2991 |
VB |
denotes |
be |
| T1347 |
2992-2999 |
VBN |
denotes |
removed |
| T1348 |
3000-3002 |
IN |
denotes |
by |
| T1349 |
3003-3012 |
NN |
denotes |
selection |
| T1350 |
3013-3017 |
IN |
denotes |
over |
| T1351 |
3018-3022 |
NN |
denotes |
time |
| T1352 |
3022-3023 |
-COMMA- |
denotes |
, |
| T1353 |
3024-3027 |
DT |
denotes |
the |
| T1354 |
3028-3037 |
VBG |
denotes |
resulting |
| T1355 |
3038-3051 |
JJ |
denotes |
bioinformatic |
| T1356 |
3052-3060 |
NNS |
denotes |
analyses |
| T1357 |
3061-3066 |
MD |
denotes |
would |
| T1358 |
3067-3069 |
VB |
denotes |
be |
| T1359 |
3070-3080 |
JJ |
denotes |
unreliable |
| R10199 |
T42372 |
T61083 |
arg2Of |
S,and |
| R10402 |
T65839 |
T58427 |
arg2Of |
and,to |
| R10411 |
T32200 |
T83554 |
arg1Of |
antibodies,"," |
| R10516 |
T86793 |
T76095 |
arg1Of |
epitopes,"," |
| R11093 |
T10324 |
T18378 |
arg2Of |
ratios,( |
| R11468 |
T43288 |
T96310 |
arg2Of |
resides,exposed |
| R11527 |
T66745 |
T45284 |
arg1Of |
trimer,revealing |
| R12287 |
T20304 |
T68204 |
arg3Of |
differences,measured |
| R12367 |
T54008 |
T35302 |
arg1Of |
diversity,was |
| R12429 |
T65828 |
T55016 |
arg2Of |
residues,with |
| R12670 |
T39503 |
T73192 |
arg1Of |
this,result |
| R1282 |
T25019 |
T14782 |
arg2Of |
camels,from |
| R1283 |
T25019 |
T86652 |
arg1Of |
camels,into |
| R1284 |
T1639 |
T86652 |
arg2Of |
humans,into |
| R1285 |
T1639 |
T23535 |
arg1Of |
humans,"," |
| R1286 |
T1639 |
T51241 |
arg1Of |
humans,where |
| R1287 |
T59854 |
T51241 |
arg2Of |
circulated,where |
| R1288 |
T67194 |
T59854 |
arg1Of |
it,circulated |
| R1289 |
T59854 |
T82528 |
arg1Of |
circulated,transiently |
| R1290 |
T1281 |
T23126 |
arg1Of |
corresponded,In |
| R1291 |
T4625 |
T23126 |
arg2Of |
contrast,In |
| R1292 |
T1281 |
T47309 |
arg1Of |
corresponded,"," |
| R1293 |
T1280 |
T1278 |
arg1Of |
outbreak,the |
| R1294 |
T1280 |
T1279 |
arg1Of |
outbreak,SARS |
| R1295 |
T1280 |
T1281 |
arg1Of |
outbreak,corresponded |
| R1296 |
T1281 |
T1282 |
arg1Of |
corresponded,to |
| R1297 |
T1286 |
T1282 |
arg2Of |
event,to |
| R1298 |
T1286 |
T1283 |
arg1Of |
event,a |
| R1299 |
T1286 |
T1284 |
arg1Of |
event,single |
| R1300 |
T1286 |
T1285 |
arg1Of |
event,zoonotic |
| R1301 |
T1291 |
T1287 |
arg1Of |
transmission,followed |
| R1302 |
T1286 |
T1287 |
arg2Of |
event,followed |
| R1303 |
T1291 |
T1288 |
arg2Of |
transmission,by |
| R1304 |
T1291 |
T1289 |
arg1Of |
transmission,extensive |
| R1305 |
T1291 |
T1290 |
arg1Of |
transmission,human-to-human |
| R1306 |
T1307 |
T1292 |
arg1Of |
is,Consequently |
| R1307 |
T1307 |
T1293 |
arg1Of |
is,"," |
| R1308 |
T1296 |
T1294 |
arg2Of |
degree,inferring |
| R1309 |
T1296 |
T1295 |
arg1Of |
degree,the |
| R1310 |
T1296 |
T1297 |
arg1Of |
degree,of |
| R1311 |
T1298 |
T1297 |
arg2Of |
selection,of |
| R1312 |
T1296 |
T1299 |
arg1Of |
degree,acting |
| R1313 |
T1299 |
T1300 |
arg1Of |
acting,upon |
| R1314 |
T1302 |
T1300 |
arg2Of |
and,upon |
| R1315 |
T1301 |
T1302 |
arg1Of |
MERS,and |
| R1316 |
T1303 |
T1302 |
arg2Of |
SARS,and |
| R1317 |
T1296 |
T1304 |
arg1Of |
degree,from |
| R13176 |
T55156 |
T17381 |
arg1Of |
vulnerabilities,extensive |
| R1318 |
T1306 |
T1304 |
arg2Of |
analysis,from |
| R1319 |
T1306 |
T1305 |
arg1Of |
analysis,dN/dS |
| R1320 |
T1294 |
T1307 |
arg1Of |
inferring,is |
| R1321 |
T1309 |
T1307 |
arg2Of |
difficult,is |
| R1322 |
T1309 |
T1308 |
arg1Of |
difficult,extremely |
| R1323 |
T1294 |
T1309 |
arg1Of |
inferring,difficult |
| R1324 |
T1358 |
T1310 |
arg1Of |
be,Importantly |
| R1325 |
T1358 |
T1311 |
arg1Of |
be,"," |
| R1326 |
T1358 |
T1312 |
arg1Of |
be,while |
| R1327 |
T1317 |
T1312 |
arg2Of |
is,while |
| R1328 |
T1314 |
T1313 |
arg1Of |
analyses,similar |
| R1329 |
T1314 |
T1315 |
arg1Of |
analyses,of |
| R1330 |
T1316 |
T1315 |
arg2Of |
SARS-CoV-2,of |
| R1331 |
T1314 |
T1317 |
arg1Of |
analyses,is |
| R1332 |
T1318 |
T1317 |
arg2Of |
desirable,is |
| R1333 |
T1314 |
T1318 |
arg1Of |
analyses,desirable |
| R1334 |
T1317 |
T1319 |
arg1Of |
is,"," |
| R1335 |
T1321 |
T1320 |
arg1Of |
to,due |
| R1336 |
T27779 |
T77953 |
arg1Of |
available,publicly |
| R1337 |
T1325 |
T1321 |
arg2Of |
variation,to |
| R1338 |
T1325 |
T1322 |
arg1Of |
variation,the |
| R1339 |
T1324 |
T1323 |
arg1Of |
genetic,low |
| R1340 |
T1325 |
T1324 |
arg1Of |
variation,genetic |
| R1341 |
T1317 |
T1326 |
arg1Of |
is,among |
| R13410 |
T81231 |
T66143 |
arg1Of |
considered,only |
| R1342 |
T1330 |
T1326 |
arg2Of |
sequences,among |
| R1343 |
T1330 |
T1327 |
arg1Of |
sequences,the |
| R1344 |
T1330 |
T1328 |
arg1Of |
sequences,current |
| R1345 |
T1330 |
T1329 |
arg1Of |
sequences,SARS-CoV-2 |
| R1346 |
T1330 |
T1331 |
arg1Of |
sequences,( |
| R1347 |
T1332 |
T1331 |
arg2Of |
as,( |
| R1348 |
T1337 |
T1331 |
arg3Of |
),( |
| R1349 |
T1335 |
T1332 |
arg2Of |
March,as |
| R1350 |
T1334 |
T1333 |
arg1Of |
17,of |
| R1351 |
T1335 |
T1334 |
arg1Of |
March,17 |
| R1352 |
T1335 |
T1336 |
arg1Of |
March,2020 |
| R1353 |
T1330 |
T1338 |
arg1Of |
sequences,"," |
| R13531 |
T59603 |
T7211 |
arg1Of |
values,( |
| R1354 |
T1330 |
T1339 |
arg1Of |
sequences,which |
| R1355 |
T1341 |
T1340 |
arg1Of |
include,likely |
| R1356 |
T1330 |
T1341 |
arg1Of |
sequences,include |
| R1357 |
T1343 |
T1341 |
arg2Of |
mutations,include |
| R1358 |
T1343 |
T1342 |
arg1Of |
mutations,deleterious |
| R1359 |
T1343 |
T1344 |
arg1Of |
mutations,that |
| R1360 |
T1343 |
T79570 |
arg1Of |
mutations,will |
| R1361 |
T1347 |
T79570 |
arg2Of |
removed,will |
| R1362 |
T1343 |
T1346 |
arg1Of |
mutations,be |
| R1363 |
T1347 |
T1346 |
arg2Of |
removed,be |
| R1364 |
T1349 |
T1347 |
arg1Of |
selection,removed |
| R13642 |
T40801 |
T50374 |
arg1Of |
are,not |
| R1365 |
T1343 |
T1347 |
arg2Of |
mutations,removed |
| R1366 |
T1349 |
T1348 |
arg2Of |
selection,by |
| R1367 |
T1347 |
T1350 |
arg1Of |
removed,over |
| R1368 |
T1351 |
T1350 |
arg2Of |
time,over |
| R1369 |
T1358 |
T1352 |
arg1Of |
be,"," |
| R1370 |
T1356 |
T1353 |
arg1Of |
analyses,the |
| R1371 |
T1356 |
T1354 |
arg1Of |
analyses,resulting |
| R1372 |
T1356 |
T1355 |
arg1Of |
analyses,bioinformatic |
| R1373 |
T1356 |
T1357 |
arg1Of |
analyses,would |
| R1374 |
T1358 |
T1357 |
arg2Of |
be,would |
| R1375 |
T1356 |
T1358 |
arg1Of |
analyses,be |
| R1376 |
T1359 |
T1358 |
arg2Of |
unreliable,be |
| R1377 |
T1356 |
T1359 |
arg1Of |
analyses,unreliable |
| R1405 |
T97622 |
T4001 |
arg1Of |
comparisons,meaningful |
| R15047 |
T97839 |
T6523 |
arg1Of |
note,interesting |
| R15085 |
T88882 |
T76117 |
arg1Of |
subject,to |
| R15217 |
T98451 |
T72837 |
arg1Of |
diversities,were |
| R15450 |
T98451 |
T74584 |
arg1Of |
diversities,per-site |
| R15619 |
T72369 |
T13118 |
arg1Of |
substitutions,synonymous |
| R15715 |
T25304 |
T83161 |
arg1Of |
sequences,gene |
| R16092 |
T20594 |
T76109 |
arg1Of |
residues,undergoing |
| R1617 |
T65828 |
T1385 |
arg2Of |
residues,exposed |
| R16170 |
T96660 |
T18812 |
arg1Of |
and,"," |
| R16314 |
T64331 |
T35591 |
arg1Of |
ratios,of |
| R16608 |
T94778 |
T33023 |
arg1Of |
as,such |
| R16738 |
T43420 |
T94778 |
arg2Of |
and,as |
| R16925 |
T69499 |
T83087 |
arg1Of |
Analysis,revealed |
| R17114 |
T25443 |
T97762 |
arg1Of |
MERS,was |
| R17754 |
T32200 |
T61088 |
arg1Of |
antibodies,targeted |
| R17994 |
T76109 |
T87805 |
arg2Of |
undergoing,be |
| R18040 |
T8574 |
T96535 |
arg1Of |
highlighted,throughout |
| R18139 |
T92287 |
T2494 |
arg1Of |
exhibited,that |
| R18674 |
T93319 |
T88231 |
arg1Of |
domains,"," |
| R18805 |
T14361 |
T29834 |
arg2Of |
outbreak,within |
| R19195 |
T69491 |
T78299 |
arg1Of |
estimates,dN/dS |
| R19265 |
T66921 |
T68204 |
arg2Of |
they,measured |
| R19546 |
T27860 |
T89667 |
arg1Of |
events,characterized |
| R19742 |
T55216 |
T19328 |
arg1Of |
We,suggest |
| R20046 |
T77842 |
T99218 |
arg1Of |
away,from |
| R20067 |
T75213 |
T82633 |
arg1Of |
peptide,fusion |
| R20318 |
T90583 |
T6621 |
arg1Of |
and,contribute |
| R20355 |
T32345 |
T90583 |
arg2Of |
environment,and |
| R20962 |
T28935 |
T19712 |
arg1Of |
behaviour,the |
| R21039 |
T1317 |
T1321 |
arg1Of |
is,to |
| R21042 |
T63130 |
T21020 |
arg2Of |
surface,on |
| R21254 |
T46357 |
T1834 |
arg2Of |
differences,of |
| R21530 |
T49099 |
T69890 |
arg1Of |
domain,the |
| R21612 |
T69286 |
T52989 |
arg1Of |
calculated,as |
| R2173 |
T70323 |
T13755 |
arg1Of |
proteins,the |
| R21921 |
T13068 |
T25400 |
arg1Of |
functionality,of |
| R22162 |
T76109 |
T65773 |
arg1Of |
undergoing,that |
| R22467 |
T55408 |
T6521 |
arg1Of |
ratio,a |
| R2265 |
T70745 |
T16791 |
arg2Of |
families,between |
| R22758 |
T20304 |
T50152 |
arg1Of |
differences,i.e. |
| R22989 |
T41479 |
T52989 |
arg2Of |
number,as |
| R23177 |
T30435 |
T87545 |
arg1Of |
targeted,to |
| R23301 |
T52371 |
T61083 |
arg1Of |
SARS,and |
| R23393 |
T80500 |
T32298 |
arg1Of |
residues,the |
| R23484 |
T13499 |
T90583 |
arg1Of |
differences,and |
| R23741 |
T62840 |
T86654 |
arg1Of |
end,that |
| R23746 |
T93319 |
T91466 |
arg1Of |
domains,helix |
| R24020 |
T41479 |
T29326 |
arg1Of |
number,the |
| R2422 |
T4769 |
T7211 |
arg2Of |
Fig. 4b,( |
| R2450 |
T69491 |
T17336 |
arg1Of |
estimates,are |
| R24616 |
T2961 |
T92960 |
arg1Of |
had,Likewise |
| R24751 |
T81231 |
T66257 |
arg1Of |
considered,in |
| R24936 |
T46208 |
T70071 |
arg1Of |
spikes,CoV |
| R25200 |
T38215 |
T76109 |
arg2Of |
rates,undergoing |
| R25217 |
T94871 |
T40910 |
arg2Of |
shield,through |
| R25896 |
T44303 |
T81866 |
arg2Of |
diversity,of |
| R26018 |
T27860 |
T18635 |
arg2Of |
events,repeated |
| R26107 |
T18790 |
T25102 |
arg1Of |
glycans,occluded |
| R2636 |
T25304 |
T83245 |
arg1Of |
sequences,of |
| R26362 |
T55156 |
T45284 |
arg2Of |
vulnerabilities,revealing |
| R26701 |
T94405 |
T32515 |
arg1Of |
model,structural |
| R26990 |
T65839 |
T13399 |
arg1Of |
and,the |
| R27719 |
T29760 |
T28968 |
arg1Of |
repeat,heptad |
| R28101 |
T60190 |
T33888 |
arg2Of |
Fig. 4c,( |
| R28264 |
T46492 |
T66630 |
arg1Of |
and,be |
| R28386 |
T46492 |
T99241 |
arg2Of |
and,with |
| R28428 |
T15412 |
T38048 |
arg1Of |
domains,of |
| R28443 |
T3483 |
T73202 |
arg1Of |
performed,To |
| R28527 |
T93319 |
T49934 |
arg1Of |
domains,which |
| R29286 |
T46492 |
T48178 |
arg1Of |
and,"," |
| R29370 |
T73192 |
T18164 |
arg1Of |
result,from |
| R29477 |
T73192 |
T1176 |
arg2Of |
result,may |
| R29835 |
T12587 |
T66257 |
arg2Of |
environment,in |
| R30100 |
T15412 |
T76133 |
arg1Of |
domains,the |
| R30304 |
T55016 |
T30445 |
arg2Of |
with,compared |
| R30596 |
T12587 |
T94028 |
arg1Of |
environment,which |
| R30852 |
T4934 |
T42560 |
arg1Of |
responses,immune |
| R3107 |
T99472 |
T4874 |
arg1Of |
constraints,greater |
| R31129 |
T55408 |
T8471 |
arg2Of |
ratio,calculated |
| R31642 |
T99472 |
T34520 |
arg1Of |
constraints,( |
| R31693 |
T70745 |
T15216 |
arg1Of |
families,viral |
| R31717 |
T46492 |
T59110 |
arg1Of |
and,which |
| R31827 |
T46492 |
T61432 |
arg1Of |
and,are |
| R32001 |
T94871 |
T14483 |
arg1Of |
shield,the |
| R32448 |
T97839 |
T87216 |
arg1Of |
note,It |
| R3248 |
T64331 |
T46802 |
arg1Of |
ratios,dN/dS |
| R32729 |
T69246 |
T66095 |
arg1Of |
domain,the |
| R3287 |
T69246 |
T52990 |
arg1Of |
domain,S2 |
| R33105 |
T41479 |
T1834 |
arg1Of |
number,of |
| R3337 |
T26380 |
T92544 |
arg1Of |
value,of |
| R34279 |
T59603 |
T86795 |
arg1Of |
values,dN/dS |
| R3433 |
T94405 |
T45778 |
arg2Of |
model,onto |
| R34390 |
T39713 |
T81231 |
arg2Of |
they,considered |
| R34568 |
T69499 |
T65163 |
arg1Of |
Analysis,of |
| R34905 |
T4586 |
T35591 |
arg2Of |
0.31,of |
| R35155 |
T92070 |
T31354 |
arg1Of |
proteins,S |
| R35799 |
T61369 |
T78947 |
arg1Of |
ratio,relative |
| R36037 |
T49843 |
T8574 |
arg2Of |
hotspots,highlighted |
| R36115 |
T54724 |
T45778 |
arg1Of |
mapped,onto |
| R36158 |
T80500 |
T2961 |
arg1Of |
residues,had |
| R36620 |
T46357 |
T91746 |
arg1Of |
differences,pairwise |
| R36891 |
T20594 |
T39672 |
arg1Of |
residues,amino-acid |
| R36961 |
T93591 |
T35302 |
arg2Of |
elevated,was |
| R37081 |
T25102 |
T46892 |
arg2Of |
occluded,are |
| R37083 |
T92849 |
T90969 |
arg2Of |
residues,Buried |
| R37258 |
T62735 |
T33520 |
arg2Of |
and,of |
| R37654 |
T98451 |
T54724 |
arg2Of |
diversities,mapped |
| R38048 |
T43420 |
T18725 |
arg1Of |
and,"," |
| R38141 |
T60681 |
T9810 |
arg1Of |
diversification,Sequence |
| R38632 |
T92849 |
T78244 |
arg1Of |
residues,on |
| R38837 |
T32345 |
T48983 |
arg1Of |
environment,immune |
| R39310 |
T40406 |
T5519 |
arg2Of |
and,as |
| R39372 |
T43288 |
T27968 |
arg2Of |
resides,for |
| R39709 |
T81231 |
T83434 |
arg2Of |
considered,be |
| R3981 |
T3483 |
T60967 |
arg1Of |
performed,"," |
| R3992 |
T75213 |
T12698 |
arg1Of |
peptide,the |
| R40189 |
T20594 |
T55010 |
arg1Of |
residues,on |
| R40238 |
T66745 |
T21467 |
arg1Of |
trimer,the |
| R40241 |
T58945 |
T28579 |
arg1Of |
number,total |
| R40679 |
T13068 |
T59646 |
arg1Of |
functionality,the |
| R40924 |
T55408 |
T2961 |
arg2Of |
ratio,had |
| R41325 |
T6621 |
T61778 |
arg1Of |
contribute,For |
| R41359 |
T26380 |
T35353 |
arg2Of |
value,with |
| R41505 |
T58945 |
T41351 |
arg2Of |
number,by |
| R41837 |
T87267 |
T68020 |
arg1Of |
glycans,the |
| R42106 |
T61083 |
T70472 |
arg1Of |
and,which |
| R42703 |
T25304 |
T27779 |
arg1Of |
sequences,available |
| R43019 |
T13068 |
T56626 |
arg1Of |
functionality,intrinsic |
| R43272 |
T25862 |
T59533 |
arg1Of |
glycosylated,fully |
| R44156 |
T20304 |
T57102 |
arg1Of |
differences,in |
| R44274 |
T58945 |
T84292 |
arg1Of |
number,of |
| R44596 |
T61083 |
T83245 |
arg2Of |
and,of |
| R44708 |
T61369 |
T23395 |
arg1Of |
ratio,the |
| R44924 |
T55408 |
T37460 |
arg1Of |
ratio,dN/dS |
| R44950 |
T8574 |
T84302 |
arg1Of |
highlighted,when |
| R45114 |
T6523 |
T15902 |
arg2Of |
interesting,is |
| R45480 |
T28935 |
T30994 |
arg1Of |
behaviour,epidemic |
| R45550 |
T54331 |
T78244 |
arg2Of |
SARS,on |
| R45689 |
T47239 |
T7211 |
arg3Of |
),( |
| R46016 |
T57528 |
T46492 |
arg2Of |
regions,and |
| R46751 |
T4558 |
T25400 |
arg2Of |
domains,of |
| R47190 |
T42487 |
T44308 |
arg1Of |
evaluation,an |
| R47308 |
T92070 |
T38048 |
arg2Of |
proteins,of |
| R47563 |
T7777 |
T27277 |
arg2Of |
regions,in |
| R47689 |
T13068 |
T18164 |
arg2Of |
functionality,from |
| R48201 |
T72369 |
T85886 |
arg2Of |
substitutions,of |
| R48312 |
T15412 |
T5507 |
arg1Of |
domains,that |
| R48342 |
T64331 |
T68155 |
arg1Of |
ratios,compared |
| R48506 |
T36827 |
T39186 |
arg1Of |
we,found |
| R49061 |
T59632 |
T61432 |
arg2Of |
unable,are |
| R49064 |
T28690 |
T40406 |
arg2Of |
disallow,and |
| R49097 |
T54724 |
T84302 |
arg2Of |
mapped,when |
| R49150 |
T29760 |
T53742 |
arg1Of |
repeat,one |
| R49381 |
T12652 |
T92287 |
arg1Of |
residues,exhibited |
| R49770 |
T49099 |
T58919 |
arg1Of |
domain,and |
| R4990 |
T61083 |
T16556 |
arg1Of |
and,was |
| R4994 |
T94871 |
T29556 |
arg1Of |
shield,glycan |
| R49965 |
T7777 |
T89562 |
arg1Of |
regions,the |
| R50123 |
T68738 |
T17336 |
arg2Of |
comparable,are |
| R50174 |
T78948 |
T68155 |
arg2Of |
with,compared |
| R50247 |
T94405 |
T25862 |
arg1Of |
model,glycosylated |
| R50373 |
T8574 |
T87038 |
arg1Of |
highlighted,"," |
| R50475 |
T19099 |
T77842 |
arg1Of |
protrude,away |
| R51193 |
T46357 |
T17558 |
arg2Of |
differences,divided |
| R51542 |
T70323 |
T76643 |
arg2Of |
proteins,of |
| R51942 |
T70323 |
T65032 |
arg1Of |
proteins,CoV |
| R52293 |
T40498 |
T99309 |
arg1Of |
lack,the |
| R52418 |
T3483 |
T74853 |
arg1Of |
performed,on |
| R52562 |
T65828 |
T35353 |
arg1Of |
residues,with |
| R53298 |
T94405 |
T98923 |
arg1Of |
model,the |
| R5341 |
T70323 |
T12704 |
arg1Of |
proteins,S |
| R5348 |
T49936 |
T62735 |
arg1Of |
MERS,and |
| R54302 |
T76109 |
T7753 |
arg2Of |
undergoing,would |
| R5439 |
T60225 |
T28690 |
arg1Of |
interactions,disallow |
| R54394 |
T39713 |
T83434 |
arg1Of |
they,be |
| R54397 |
T4558 |
T95940 |
arg1Of |
domains,these |
| R54626 |
T39186 |
T18701 |
arg1Of |
found,Firstly |
| R54761 |
T15412 |
T83531 |
arg2Of |
domains,on |
| R54914 |
T97839 |
T19232 |
arg1Of |
note,to |
| R55146 |
T86793 |
T90961 |
arg2Of |
epitopes,at |
| R5522 |
T46492 |
T30950 |
arg1Of |
and,buried |
| R55552 |
T39186 |
T74266 |
arg1Of |
found,"," |
| R56320 |
T59603 |
T11718 |
arg1Of |
values,higher |
| R56401 |
T69246 |
T23472 |
arg2Of |
domain,in |
| R56816 |
T63979 |
T74853 |
arg2Of |
level,on |
| R56819 |
T54008 |
T13224 |
arg1Of |
diversity,amino-acid |
| R56933 |
T46492 |
T50177 |
arg1Of |
and,that |
| R56973 |
T25052 |
T46492 |
arg1Of |
residues,and |
| R5709 |
T70745 |
T5519 |
arg1Of |
families,as |
| R57227 |
T79756 |
T40313 |
arg1Of |
diversification,amino-acid |
| R57764 |
T6621 |
T32139 |
arg1Of |
contribute,likely |
| R57790 |
T61369 |
T65163 |
arg2Of |
ratio,of |
| R58419 |
T79406 |
T92544 |
arg2Of |
0.45,of |
| R58427 |
T40801 |
T27804 |
arg1Of |
are,"," |
| R58435 |
T58945 |
T50799 |
arg1Of |
number,the |
| R5847 |
T17336 |
T85225 |
arg2Of |
are,Although |
| R58586 |
T12652 |
T4328 |
arg2Of |
residues,exposed |
| R5883 |
T86793 |
T69090 |
arg2Of |
epitopes,known |
| R58840 |
T26380 |
T91154 |
arg1Of |
value,a |
| R58879 |
T68204 |
T48812 |
arg2Of |
measured,are |
| R59010 |
T48849 |
T57102 |
arg2Of |
ecology,in |
| R59094 |
T12587 |
T26996 |
arg1Of |
environment,the |
| R5916 |
T24392 |
T77635 |
arg2Of |
MERS,on |
| R59233 |
T40498 |
T83531 |
arg1Of |
lack,on |
| R60366 |
T25304 |
T6148 |
arg2Of |
sequences,using |
| R60567 |
T66921 |
T48812 |
arg1Of |
they,are |
| R60603 |
T13499 |
T59995 |
arg1Of |
differences,in |
| R60609 |
T38215 |
T49022 |
arg1Of |
rates,higher |
| R61523 |
T6621 |
T58427 |
arg1Of |
contribute,to |
| R61595 |
T46492 |
T59632 |
arg1Of |
and,unable |
| R61681 |
T65633 |
T71210 |
arg1Of |
We,hypothesized |
| R62080 |
T8574 |
T5765 |
arg2Of |
highlighted,were |
| R62100 |
T79756 |
T38057 |
arg2Of |
diversification,of |
| R62161 |
T75213 |
T29294 |
arg1Of |
peptide,"," |
| R62547 |
T32345 |
T33520 |
arg1Of |
environment,of |
| R63070 |
T43199 |
T26807 |
arg2Of |
diversity,observed |
| R63316 |
T6621 |
T85630 |
arg1Of |
contribute,"," |
| R63445 |
T8574 |
T92418 |
arg1Of |
highlighted,Furthermore |
| R63756 |
T63979 |
T53700 |
arg1Of |
level,residue-specific |
| R64002 |
T72369 |
T18378 |
arg1Of |
substitutions,( |
| R64157 |
T97839 |
T15902 |
arg1Of |
note,is |
| R64305 |
T80559 |
T61778 |
arg2Of |
example,For |
| R64448 |
T49099 |
T83248 |
arg1Of |
domain,N-terminal |
| R64905 |
T64331 |
T42940 |
arg2Of |
ratios,had |
| R64991 |
T38215 |
T48007 |
arg1Of |
rates,of |
| R65049 |
T4934 |
T30435 |
arg1Of |
responses,targeted |
| R65597 |
T93319 |
T43420 |
arg2Of |
domains,and |
| R65608 |
T60790 |
T58919 |
arg2Of |
domains,and |
| R6622 |
T92070 |
T48648 |
arg1Of |
proteins,MERS |
| R66651 |
T73192 |
T73414 |
arg1Of |
result,that |
| R66839 |
T98451 |
T76352 |
arg1Of |
diversities,amino-acid |
| R67157 |
T54008 |
T93591 |
arg2Of |
diversity,elevated |
| R6736 |
T58945 |
T17558 |
arg1Of |
number,divided |
| R67380 |
T42487 |
T38057 |
arg1Of |
evaluation,of |
| R68081 |
T78585 |
T27968 |
arg1Of |
2.82,for |
| R68137 |
T88882 |
T23715 |
arg2Of |
subject,are |
| R68351 |
T40498 |
T81866 |
arg1Of |
lack,of |
| R68490 |
T14361 |
T7384 |
arg1Of |
outbreak,each |
| R6860 |
T10324 |
T58779 |
arg1Of |
ratios,dN/dS |
| R68632 |
T70323 |
T33888 |
arg1Of |
proteins,( |
| R6866 |
T69286 |
T16556 |
arg2Of |
calculated,was |
| R68851 |
T2961 |
T14475 |
arg1Of |
had,"," |
| R69077 |
T68204 |
T55529 |
arg1Of |
measured,in |
| R69300 |
T23381 |
T45120 |
arg2Of |
0.10,of |
| R69352 |
T60790 |
T18570 |
arg1Of |
domains,receptor-binding |
| R6966 |
T58919 |
T51281 |
arg2Of |
and,as |
| R69926 |
T46208 |
T14534 |
arg2Of |
spikes,of |
| R69989 |
T8574 |
T21020 |
arg1Of |
highlighted,on |
| R70051 |
T63244 |
T77547 |
arg2Of |
mutations,of |
| R70296 |
T59603 |
T92287 |
arg2Of |
values,exhibited |
| R71053 |
T61369 |
T85886 |
arg1Of |
ratio,of |
| R71690 |
T86793 |
T11216 |
arg2Of |
epitopes,reduced |
| R71746 |
T85021 |
T19591 |
arg1Of |
outbreaks,SARS |
| R71969 |
T42372 |
T72419 |
arg1Of |
S,MERS |
| R72145 |
T60681 |
T14534 |
arg1Of |
diversification,of |
| R72203 |
T20594 |
T7753 |
arg1Of |
residues,would |
| R72593 |
T58857 |
T6148 |
arg1Of |
we,using |
| R72861 |
T55109 |
T1585 |
arg1Of |
solvent-accessible,"," |
| R72986 |
T68523 |
T71413 |
arg2Of |
and,of |
| R7301 |
T72369 |
T63573 |
arg1Of |
substitutions,nucleotide |
| R73123 |
T27860 |
T14782 |
arg1Of |
events,from |
| R73473 |
T30435 |
T66630 |
arg2Of |
targeted,be |
| R73701 |
T80500 |
T12634 |
arg2Of |
residues,buried |
| R74212 |
T32200 |
T30461 |
arg1Of |
antibodies,neutralizing |
| R74679 |
T94405 |
T76643 |
arg1Of |
model,of |
| R74990 |
T61088 |
T96660 |
arg1Of |
targeted,and |
| R75268 |
T55216 |
T15548 |
arg1Of |
We,would |
| R75726 |
T48991 |
T34520 |
arg2Of |
Fig. 4a,( |
| R7575 |
T64331 |
T56294 |
arg1Of |
ratios,mean |
| R75794 |
T94055 |
T84292 |
arg2Of |
comparisons,of |
| R75798 |
T85021 |
T62735 |
arg2Of |
outbreaks,and |
| R76231 |
T63979 |
T83914 |
arg1Of |
level,a |
| R76412 |
T40801 |
T85225 |
arg1Of |
are,Although |
| R76452 |
T81231 |
T72942 |
arg2Of |
considered,can |
| R77034 |
T39672 |
T1585 |
arg2Of |
amino-acid,"," |
| R77296 |
T58857 |
T3483 |
arg1Of |
we,performed |
| R77763 |
T54724 |
T72837 |
arg2Of |
mapped,were |
| R77783 |
T80500 |
T77635 |
arg1Of |
residues,on |
| R78066 |
T15412 |
T19099 |
arg1Of |
domains,protrude |
| R78169 |
T73192 |
T19328 |
arg2Of |
result,suggest |
| R78238 |
T67674 |
T40801 |
arg2Of |
comparable,are |
| R78452 |
T49843 |
T77547 |
arg1Of |
hotspots,of |
| R78533 |
T92849 |
T42940 |
arg1Of |
residues,had |
| R78557 |
T98636 |
T79458 |
arg1Of |
dN/dS,thus |
| R78903 |
T15412 |
T29918 |
arg1Of |
domains,receptor-binding |
| R78916 |
T28935 |
T59995 |
arg2Of |
behaviour,in |
| R79260 |
T67674 |
T5187 |
arg1Of |
comparable,directly |
| R79279 |
T12679 |
T68523 |
arg2Of |
CoVs,and |
| R79333 |
T27628 |
T33888 |
arg3Of |
),( |
| R7964 |
T89667 |
T97762 |
arg2Of |
characterized,was |
| R79815 |
T60225 |
T86262 |
arg1Of |
interactions,host-virus |
| R79922 |
T94055 |
T34101 |
arg1Of |
comparisons,pairwise |
| R80658 |
T18790 |
T44481 |
arg2Of |
glycans,by |
| R81049 |
T32200 |
T51281 |
arg1Of |
antibodies,as |
| R81060 |
T46492 |
T25102 |
arg2Of |
and,occluded |
| R81127 |
T55156 |
T13067 |
arg1Of |
vulnerabilities,permeating |
| R81192 |
T6148 |
T3483 |
arg3Of |
using,performed |
| R81741 |
T86087 |
T48007 |
arg2Of |
mutations,of |
| R8222 |
T3483 |
T62380 |
arg1Of |
performed,"," |
| R82494 |
T88882 |
T33407 |
arg1Of |
subject,likely |
| R82820 |
T99241 |
T52952 |
arg2Of |
with,compared |
| R83184 |
T29760 |
T29294 |
arg2Of |
repeat,"," |
| R83333 |
T67674 |
T16791 |
arg1Of |
comparable,between |
| R83504 |
T32200 |
T53019 |
arg2Of |
antibodies,by |
| R83519 |
T66745 |
T96535 |
arg2Of |
trimer,throughout |
| R84039 |
T75213 |
T43420 |
arg1Of |
peptide,and |
| R84142 |
T4934 |
T87263 |
arg2Of |
responses,by |
| R84233 |
T43199 |
T13552 |
arg1Of |
diversity,genetic |
| R84300 |
T99472 |
T76117 |
arg2Of |
constraints,to |
| R84393 |
T93319 |
T26621 |
arg1Of |
domains,central |
| R84573 |
T63130 |
T65568 |
arg1Of |
surface,protein |
| R84767 |
T4934 |
T84547 |
arg1Of |
responses,host |
| R84782 |
T93319 |
T88882 |
arg1Of |
domains,subject |
| R85070 |
T20304 |
T1345 |
arg1Of |
differences,( |
| R85221 |
T20594 |
T55109 |
arg1Of |
residues,solvent-accessible |
| R85227 |
T93591 |
T39186 |
arg2Of |
elevated,found |
| R85283 |
T7777 |
T23472 |
arg1Of |
regions,in |
| R85323 |
T5319 |
T34520 |
arg3Of |
),( |
| R85372 |
T63927 |
T40801 |
arg1Of |
they,are |
| R85398 |
T70323 |
T14482 |
arg1Of |
proteins,respective |
| R85450 |
T97622 |
T28690 |
arg2Of |
comparisons,disallow |
| R85917 |
T12679 |
T70297 |
arg1Of |
CoVs,MERS |
| R86127 |
T40801 |
T88580 |
arg1Of |
are,) |
| R86135 |
T46492 |
T30435 |
arg2Of |
and,targeted |
| R86243 |
T49843 |
T5765 |
arg1Of |
hotspots,were |
| R86473 |
T20304 |
T58234 |
arg1Of |
differences,multiple |
| R8726 |
T11216 |
T96660 |
arg2Of |
reduced,and |
| R87991 |
T19328 |
T15548 |
arg2Of |
suggest,would |
| R88109 |
T12587 |
T55529 |
arg2Of |
environment,in |
| R88392 |
T30580 |
T18378 |
arg3Of |
),( |
| R88573 |
T92287 |
T83087 |
arg2Of |
exhibited,revealed |
| R88738 |
T13118 |
T53309 |
arg1Of |
synonymous,non-synonymous |
| R8907 |
T81413 |
T68523 |
arg1Of |
SARS,and |
| R89891 |
T11216 |
T27277 |
arg1Of |
reduced,in |
| R90166 |
T2961 |
T30445 |
arg1Of |
had,compared |
| R90259 |
T42487 |
T3483 |
arg2Of |
evaluation,performed |
| R90310 |
T39713 |
T72942 |
arg1Of |
they,can |
| R90378 |
T32345 |
T22228 |
arg1Of |
environment,host |
| R90788 |
T94871 |
T71413 |
arg1Of |
shield,of |
| R91100 |
T46492 |
T46892 |
arg1Of |
and,are |
| R91245 |
T39503 |
T1176 |
arg1Of |
this,may |
| R91860 |
T68738 |
T29834 |
arg1Of |
comparable,within |
| R91880 |
T13067 |
T40910 |
arg1Of |
permeating,through |
| R92159 |
T27860 |
T47196 |
arg2Of |
events,by |
| R92469 |
T43199 |
T65839 |
arg1Of |
diversity,and |
| R93094 |
T13118 |
T78726 |
arg1Of |
synonymous,to |
| R93413 |
T40498 |
T97839 |
arg2Of |
lack,note |
| R93551 |
T10324 |
T58404 |
arg1Of |
ratios,i.e. |
| R93652 |
T93319 |
T34460 |
arg1Of |
domains,the |
| R9367 |
T86793 |
T61088 |
arg2Of |
epitopes,targeted |
| R93854 |
T61083 |
T69286 |
arg2Of |
and,calculated |
| R94248 |
T93591 |
T6773 |
arg1Of |
elevated,that |
| R94313 |
T13068 |
T77011 |
arg1Of |
functionality,receptor-binding |
| R94318 |
T98636 |
T65839 |
arg2Of |
dN/dS,and |
| R94377 |
T14361 |
T38180 |
arg1Of |
outbreak,viral |
| R94463 |
T62840 |
T73202 |
arg2Of |
end,To |
| R94531 |
T78585 |
T78948 |
arg2Of |
2.82,with |
| R94598 |
T8574 |
T91452 |
arg1Of |
highlighted,"," |
| R94608 |
T61083 |
T3167 |
arg1Of |
and,"," |
| R95057 |
T60790 |
T18721 |
arg1Of |
domains,the |
| R95251 |
T93319 |
T23715 |
arg1Of |
domains,are |
| R95337 |
T63927 |
T67674 |
arg1Of |
they,comparable |
| R95749 |
T27449 |
T55010 |
arg2Of |
proteins,on |
| R95788 |
T76109 |
T52952 |
arg1Of |
undergoing,compared |
| R95941 |
T20594 |
T87805 |
arg1Of |
residues,be |
| R96091 |
T76109 |
T71210 |
arg2Of |
undergoing,hypothesized |
| R96110 |
T99472 |
T38302 |
arg1Of |
constraints,functional |
| R96137 |
T25443 |
T89667 |
arg2Of |
MERS,characterized |
| R96156 |
T27449 |
T92344 |
arg1Of |
proteins,S |
| R96223 |
T86793 |
T94778 |
arg1Of |
epitopes,as |
| R96503 |
T27860 |
T30054 |
arg1Of |
events,spillover |
| R96524 |
T30435 |
T59632 |
arg2Of |
targeted,unable |
| R96796 |
T55408 |
T45120 |
arg1Of |
ratio,of |
| R97033 |
T81231 |
T40406 |
arg1Of |
considered,and |
| R97035 |
T48849 |
T44931 |
arg1Of |
ecology,transmission |
| R97244 |
T87267 |
T99218 |
arg2Of |
glycans,from |
| R97765 |
T11718 |
T88501 |
arg1Of |
higher,significantly |
| R98281 |
T51281 |
T32640 |
arg1Of |
as,such |
| R98488 |
T46357 |
T51205 |
arg2Of |
differences,observed |
| R98710 |
T93591 |
T90961 |
arg1Of |
elevated,at |
| R99168 |
T63130 |
T89986 |
arg1Of |
surface,the |
| R99316 |
T69491 |
T68738 |
arg1Of |
estimates,comparable |
| R99374 |
T44303 |
T9331 |
arg1Of |
diversity,amino-acid |
