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PubMed:32277065 / 144-154 JSONTXT 5 Projects

Halting coronavirus polymerase. The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.

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last updated at 2021-03-15 02:34:46 UTC

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