> top > projects > LitCovid-PubTator > docs > PMC:7755033 > annotations
LitCovid-PubTator  

PMC:7755033 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue tao:has_database_id
2 45-63 Species denotes Withania somnifera Tax:126910
3 116-124 Disease denotes COVID-19 MESH:C000657245
33 258-271 Species denotes Coronaviruses Tax:11118
34 306-311 Species denotes human Tax:9606
51 323-332 Disease denotes infection MESH:D007239
52 427-435 Disease denotes COVID-19 MESH:C000657245
35 535-564 Species denotes Withania somnifera (L.) Dunal Tax:126910
45 566-568 Species denotes WS Tax:126910
46 688-690 Species denotes WS Tax:126910
36 727-737 Species denotes SARS-CoV-2 Tax:2697049
37 758-763 Species denotes human Tax:9606
29 764-768 Gene denotes ACE2 Gene:59272
47 1012-1014 Species denotes WS Tax:126910
38 1061-1066 Species denotes human Tax:9606
30 1067-1071 Gene denotes ACE2 Gene:59272
39 1082-1085 Species denotes SAR Tax:2698737
40 1086-1089 Species denotes CoV Tax:11118
41 1094-1104 Species denotes SARS-CoV-2 Tax:2697049
32 1105-1110 Gene denotes spike Gene:43740568
42 1149-1159 Species denotes SARS-CoV-2 Tax:2697049
43 1383-1386 Species denotes SAR Tax:2698737
49 1424-1430 Chemical denotes oxygen MESH:D010100
50 1444-1455 Chemical denotes withanolide MESH:D054358
44 1564-1574 Species denotes SARS-CoV-2 Tax:2697049
31 1575-1580 Gene denotes spike Gene:43740568
48 1800-1802 Species denotes WS Tax:126910
53 1996-2004 Disease denotes COVID-19 MESH:C000657245
75 2147-2161 Disease denotes viral diseases MESH:D001102
76 2282-2315 Disease denotes Severe Acute Respiratory Syndrome MESH:D045169
69 2337-2341 Species denotes H1N1 Tax:114727
77 2364-2396 Disease denotes Middle East Respiratory Syndrome MESH:D018352
78 2398-2402 Disease denotes MERS MESH:D018352
79 2520-2529 Disease denotes pneumonia MESH:D011014
70 2649-2660 Species denotes coronavirus Tax:11118
71 2685-2698 Species denotes coronaviridae Tax:11118
72 2778-2788 Species denotes SARS-CoV-2 Tax:2697049
80 2819-2827 Disease denotes COVID-19 MESH:C000657245
73 2855-2870 Species denotes β-coronaviruses Tax:694002
81 2998-3006 Disease denotes COVID-19 MESH:C000657245
82 3021-3027 Disease denotes deaths MESH:D003643
83 3141-3147 Disease denotes deaths MESH:D003643
74 3202-3213 Species denotes coronavirus Tax:11118
97 3231-3244 Species denotes Coronaviruses Tax:11118
98 3288-3302 Species denotes ssRNA) viruses Tax:439488
96 3396-3401 Gene denotes spike Gene:43740568
99 3490-3503 Species denotes coronaviruses Tax:11118
100 3529-3539 Species denotes SARS-CoV-2 Tax:2697049
101 3588-3596 Species denotes SARS-CoV Tax:694009
102 3601-3609 Species denotes MERS-CoV Tax:1335626
103 3674-3685 Species denotes Coronavirus Tax:11118
105 3935-3944 Disease denotes pneumonia MESH:D011014
106 3964-3992 Disease denotes respiratory tract infections MESH:D012141
107 3997-4020 Disease denotes multi-organ dysfunction MESH:D009102
104 4079-4089 Species denotes SARS-CoV-2 Tax:2697049
109 5167-5180 Species denotes coronaviruses Tax:11118
146 5438-5446 Disease denotes COVID-19 MESH:C000657245
147 5473-5481 Disease denotes COVID-19 MESH:C000657245
133 5487-5493 Species denotes People Tax:9606
132 5601-5606 Gene denotes IFN-α Gene:3439
141 5609-5628 Chemical denotes lopinavir/ritonavir MESH:C558899
142 5630-5651 Chemical denotes chloroquine phosphate MESH:C023676
143 5653-5662 Chemical denotes ribavirin MESH:D012254
144 5667-5674 Chemical denotes arbidol MESH:C086979
134 5763-5780 Species denotes novel coronavirus Tax:2697049
148 5789-5798 Disease denotes pneumonia MESH:D011014
145 5838-5857 Chemical denotes lopinavir/ritonavir MESH:C558899
149 5879-5887 Disease denotes COVID-19 MESH:C000657245
150 5888-5896 Disease denotes infected MESH:D007239
135 5897-5905 Species denotes patients Tax:9606
151 5967-5970 Disease denotes HIV MESH:D015658
136 5971-5979 Species denotes patients Tax:9606
137 6040-6045 Species denotes human Tax:9606
138 6144-6151 Species denotes ferrets Tax:9669
139 6176-6180 Species denotes mice Tax:10090
152 6280-6290 Disease denotes infections MESH:D007239
140 6296-6304 Species denotes SARS-CoV Tax:694009
153 6337-6365 Disease denotes respiratory tract infections MESH:D012141
180 6420-6425 Species denotes human Tax:9606
181 6437-6441 Species denotes CoVs Tax:11118
189 6491-6501 Chemical denotes nucleoside MESH:D009705
190 6511-6521 Chemical denotes remdesivir MESH:C000606551
191 6523-6543 Chemical denotes tenofovir disoproxil MESH:D000068698
192 6551-6561 Chemical denotes umifenovir MESH:C086979
193 6563-6570 Chemical denotes arbidol MESH:C086979
194 6576-6586 Chemical denotes lamivudine MESH:D019259
195 6588-6591 Chemical denotes 3TC MESH:D019259
182 6708-6713 Species denotes human Tax:9606
183 6725-6738 Species denotes coronaviruses Tax:11118
175 6790-6794 Gene denotes ACE2 Gene:59272
184 7055-7065 Species denotes SARS-CoV-2 Tax:2697049
185 7125-7135 Species denotes SARS-CoV-2 Tax:2697049
186 7175-7180 Species denotes human Tax:9606
176 7181-7185 Gene denotes ACE2 Gene:59272
187 7334-7344 Species denotes SARS-CoV-2 Tax:2697049
188 7540-7545 Species denotes human Tax:9606
177 7546-7550 Gene denotes ACE2 Gene:59272
178 7641-7646 Gene denotes Spike Gene:43740568
179 7847-7851 Gene denotes ACE2 Gene:59272
209 8015-8025 Species denotes SARS-CoV-2 Tax:2697049
205 8189-8195 Gene denotes PL-pro Gene:43740578
210 8198-8205 Chemical denotes 3CL-pro
208 8395-8401 Gene denotes PL-pro Gene:43740578
206 8777-8782 Gene denotes Nsp10 Gene:43740578
211 9025-9034 Disease denotes infection MESH:D007239
207 9056-9061 Gene denotes Nsp10 Gene:43740578
212 9130-9138 Disease denotes COVID-19 MESH:C000657245
213 9139-9148 Disease denotes infection MESH:D007239
216 9389-9397 Disease denotes toxicity MESH:D064420
217 10240-10248 Disease denotes toxicity MESH:D064420
224 10713-10731 Species denotes Withania somnifera Tax:126910
227 10733-10735 Species denotes WS Tax:126910
225 10764-10771 Species denotes Ginseng Tax:4054
226 10778-10789 Species denotes Ashwagandha Tax:126910
228 11057-11068 Disease denotes hypotensive MESH:D007022
229 11122-11127 Disease denotes tumor MESH:D009369
232 11164-11193 Species denotes Withania somnifera (L.) Dunal Tax:126910
233 11382-11393 Species denotes ashwagandha Tax:126910
251 11469-11481 Chemical denotes withanolides MESH:D054358
253 11570-11575 Disease denotes tumor MESH:D009369
247 11686-11688 Species denotes WS Tax:126910
244 11697-11701 Species denotes H1N1 Tax:114727
252 11738-11747 Chemical denotes withanone MESH:C560597
248 11753-11755 Species denotes WS Tax:126910
245 11764-11781 Species denotes novel coronavirus Tax:2697049
249 11922-11924 Species denotes WS Tax:126910
250 12039-12041 Species denotes WS Tax:126910
246 12093-12103 Species denotes SARS-CoV-2 Tax:2697049
257 12165-12177 Chemical denotes withanolides MESH:D054358
256 12183-12201 Species denotes Withania somnifera Tax:126910
261 12795-12835 Disease denotes Viscosalactone B Anaferine PubChem CID MESH:D006509
262 12987-13025 Disease denotes Alkaloid   Withasomnine   PubChem CID
263 13056-13064 CellLine denotes C12H12N2 CVCL:0189
273 13105-13117 Chemical denotes Withanolides MESH:D054358
274 13129-13141 Chemical denotes withanolides MESH:D054358
275 13143-13152 Chemical denotes , B, D, E
276 13154-13163 Chemical denotes anaferine
277 13165-13177 Chemical denotes withaferin A
278 13179-13191 Chemical denotes withasomnine MESH:C568582
279 13193-13202 Chemical denotes withanone MESH:C560597
280 13207-13223 Chemical denotes viscosalactone B
281 13407-13415 Chemical denotes lactones MESH:D007783
288 13456-13460 Gene denotes ACE2 Gene:59272
292 13529-13549 Disease denotes SARS-CoV-2 infection MESH:C000657245
291 13857-13869 Chemical denotes withanolides MESH:D054358
290 13875-13877 Species denotes WS Tax:126910
289 13972-13982 Species denotes SARS-CoV-2 Tax:2697049
293 14005-14013 Disease denotes COVID-19 MESH:C000657245
313 14071-14079 Chemical denotes losartan MESH:D019808
314 14081-14093 Chemical denotes procainamide MESH:D011342
315 14095-14105 Chemical denotes cinacalcet MESH:D000069449
316 14107-14114 Chemical denotes arbidol MESH:C086979
317 14116-14134 Chemical denotes hydroxychloroquine MESH:D006886
318 14136-14146 Chemical denotes oberadilol
319 14151-14161 Chemical denotes poziotinib MESH:C557213
309 14269-14274 Species denotes human Tax:9606
307 14275-14279 Gene denotes ACE2 Gene:59272
310 14290-14298 Species denotes SARS-CoV Tax:694009
311 14303-14313 Species denotes SARS-CoV-2 Tax:2697049
312 14331-14336 Gene denotes Spike Gene:43740568
308 14489-14494 Gene denotes Nsp10 Gene:43740578
324 14869-14871 Species denotes WS Tax:126910
323 15177-15183 Species denotes humans Tax:9606
325 15246-15248 Species denotes WS Tax:126910
327 15622-15632 Disease denotes CID-156419
329 16090-16098 Chemical denotes hydrogen MESH:D006859
331 16611-16625 Disease denotes embryotoxicity
336 16854-16856 Species denotes WS Tax:126910
338 17054-17062 Chemical denotes hydrogen MESH:D006859
339 17090-17098 Chemical denotes hydrogen MESH:D006859
337 17282-17284 Species denotes WS Tax:126910
341 19448-19454 Chemical denotes carbon MESH:D002244
350 20420-20422 Chemical denotes sp MESH:C000604007
351 20434-20441 Chemical denotes carbons MESH:D002244
352 20457-20463 Chemical denotes carbon MESH:D002244
353 20603-20607 Chemical denotes ESOL
349 20763-20768 Species denotes human Tax:9606
354 20838-20844 Chemical denotes Caco-2
355 20969-20977 Disease denotes toxicity MESH:D064420
369 21073-21078 Species denotes human Tax:9606
365 21079-21083 Gene denotes ACE2 Gene:59272
370 21094-21102 Species denotes SARS-CoV Tax:694009
371 21107-21117 Species denotes SARS-CoV-2 Tax:2697049
366 21168-21172 Gene denotes Bank Gene:55024
368 21176-21179 Gene denotes PDB Gene:5131
367 21208-21211 Gene denotes pdb Gene:5131
372 21377-21385 Chemical denotes hydrogen MESH:D006859
373 21460-21465 Chemical denotes water MESH:D014867
413 21588-21591 Gene denotes PDB Gene:5131
398 21636-21665 Gene denotes Angiotensin converting enzyme Gene:1636
414 21682-21690 Species denotes SARS-CoV Tax:694009
404 21691-21696 Gene denotes spike Gene:43740568
412 21711-21714 Gene denotes PDB Gene:5131
415 21726-21736 Species denotes SARS-CoV-2 Tax:2697049
403 21737-21742 Gene denotes spike Gene:43740568
411 21757-21760 Gene denotes PDB Gene:5131
416 21772-21782 Species denotes SARS-CoV-2 Tax:2697049
410 21798-21801 Gene denotes PDB Gene:5131
417 21813-21821 Species denotes SARS-CoV Tax:694009
409 21857-21860 Gene denotes PDB Gene:5131
418 21896-21906 Species denotes SARS-CoV-2 Tax:2697049
408 21908-21911 Gene denotes PDB Gene:5131
399 21923-21929 Gene denotes Nsp-10 Gene:43740578
419 21950-21960 Species denotes SARS-CoV-2 Tax:2697049
407 21962-21965 Gene denotes PDB Gene:5131
420 21977-21987 Species denotes SARS-CoV-2 Tax:2697049
402 21988-21993 Gene denotes spike Gene:43740568
406 22019-22022 Gene denotes PDB Gene:5131
421 22037-22047 Species denotes SARS-CoV-2 Tax:2697049
401 22048-22053 Gene denotes spike Gene:43740568
400 22095-22099 Gene denotes ACE2 Gene:59272
405 22101-22104 Gene denotes PDB Gene:5131
433 22411-22414 Chemical denotes 3CL
432 22420-22426 Gene denotes PL-pro Gene:43740578
429 22430-22438 Species denotes SARS-CoV Tax:694009
430 22440-22450 Species denotes SARS-CoV-2 Tax:2697049
431 22455-22460 Species denotes human Tax:9606
428 22461-22465 Gene denotes ACE2 Gene:59272
443 22690-22692 Species denotes WS Tax:126910
440 22701-22706 Species denotes human Tax:9606
439 22707-22711 Gene denotes ACE2 Gene:59272
441 22722-22730 Species denotes SARS-CoV Tax:694009
442 22735-22745 Species denotes SARS-CoV-2 Tax:2697049
454 23379-23390 Chemical denotes withanolide MESH:D054358
451 23402-23407 Species denotes human Tax:9606
450 23408-23412 Gene denotes ACE2 Gene:59272
452 23435-23443 Species denotes SARS-CoV Tax:694009
453 23448-23458 Species denotes SARS-CoV-2 Tax:2697049
455 23682-23684 Chemical denotes BE
457 24979-24987 Chemical denotes hydrogen MESH:D006859
461 25277-25279 Species denotes WS Tax:126910
460 25322-25327 Species denotes human Tax:9606
463 25502-25510 Disease denotes Toxicity MESH:D064420
467 25527-25535 Disease denotes Toxicity MESH:D064420
466 25726-25728 Species denotes WS Tax:126910
469 26615-26617 Species denotes WS Tax:126910
471 27058-27071 Chemical denotes heme-thiolate
479 28164-28170 Disease denotes Osiris
476 28291-28293 Species denotes WS Tax:126910
477 28391-28399 Chemical denotes hydrogen MESH:D006859
478 28412-28420 Chemical denotes hydrogen MESH:D006859
497 28979-28981 Species denotes WS Tax:126910
499 29005-29017 Chemical denotes withanolides MESH:D054358
493 29149-29159 Species denotes SARS CoV-2 Tax:2697049
498 29160-29165 Gene denotes spike Gene:43740568
492 29191-29194 Gene denotes PDB Gene:5131
494 29209-29219 Species denotes SARS CoV-2 Tax:2697049
491 29242-29245 Gene denotes PDB Gene:5131
501 29434-29438 Disease denotes HTMD
495 29627-29637 Species denotes SARS-Cov-2 Tax:2697049
500 29651-29662 Chemical denotes withanolide MESH:D054358
496 29677-29687 Species denotes SARS CoV-2 Tax:2697049
511 29842-29850 Species denotes SARS-CoV Tax:694009
509 29851-29856 Gene denotes spike Gene:43740568
508 29871-29874 Gene denotes PDB Gene:5131
512 29908-29918 Species denotes SARS-CoV-2 Tax:2697049
510 29934-29937 Gene denotes PDB Gene:5131
513 29953-29964 Chemical denotes withanolide MESH:D054358
515 30469-30471 Species denotes WS Tax:126910
520 30842-30844 Species denotes WS Tax:126910
521 30992-30994 Species denotes WS Tax:126910
522 31085-31095 Chemical denotes cinacalcet MESH:D000069449
523 31100-31110 Chemical denotes poziotinib MESH:C557213
532 31193-31195 Species denotes WS Tax:126910
533 31260-31268 Chemical denotes Losartan
534 31270-31282 Chemical denotes Procainamide MESH:D011342
535 31284-31294 Chemical denotes Cinacalcet MESH:D000069449
536 31296-31303 Chemical denotes Arbidol MESH:C086979
537 31305-31323 Chemical denotes Hydroxychloroquine MESH:D006886
538 31325-31335 Chemical denotes Oberadilol
539 31337-31347 Chemical denotes Poziotinib MESH:C557213
558 31523-31531 Chemical denotes Hydrogen MESH:D006859
559 31556-31564 Chemical denotes Hydrogen MESH:D006859
560 31652-31664 Chemical denotes Withaferin A
561 31709-31720 Chemical denotes Withanolide MESH:D054358
562 31767-31778 Chemical denotes Withanolide MESH:D054358
563 31825-31836 Chemical denotes Withanolide MESH:D054358
564 31883-31894 Chemical denotes Withanolide MESH:D054358
565 31942-31951 Chemical denotes Withanone MESH:C560597
566 31996-32010 Chemical denotes Viscosalactone
567 32058-32067 Chemical denotes Anaferine
568 32112-32124 Chemical denotes Withasomnine MESH:C568582
569 32171-32179 Chemical denotes Losartan
570 32223-32235 Chemical denotes Procainamide MESH:D011342
571 32280-32290 Chemical denotes Cinacalcet MESH:D000069449
572 32333-32340 Chemical denotes Arbidol MESH:C086979
573 32381-32399 Chemical denotes Hydroxychloroquine MESH:D006886
574 32445-32455 Chemical denotes Oberadilol
575 32497-32507 Chemical denotes Poziotinib MESH:C557213
579 32750-32760 Chemical denotes cLogarithm
580 32803-32812 Chemical denotes n-octanol MESH:D020003
581 32817-32822 Chemical denotes water MESH:D014867
585 32824-32826 Species denotes WS Tax:126910
586 33101-33111 Chemical denotes cinacalcet MESH:D000069449
587 33193-33203 Chemical denotes poziotinib MESH:C557213
596 33277-33279 Species denotes WS Tax:126910
597 33344-33352 Chemical denotes Losartan
598 33354-33366 Chemical denotes Procainamide MESH:D011342
599 33368-33378 Chemical denotes Cinacalcet MESH:D000069449
600 33380-33387 Chemical denotes Arbidol MESH:C086979
601 33389-33407 Chemical denotes Hydroxychloroquine MESH:D006886
602 33409-33419 Chemical denotes Oberadilol
603 33421-33431 Chemical denotes Poziotinib MESH:C557213
620 33451-33454 Chemical denotes GNo
621 33527-33542 Chemical denotes Withaferin A 1
622 33559-33572 Chemical denotes Withanolide A
623 33625-33636 Chemical denotes Withanolide MESH:D054358
624 33658-33669 Chemical denotes Withanolide MESH:D054358
625 33691-33700 Chemical denotes Withanone MESH:C560597
626 33720-33736 Chemical denotes Viscosalactone B
627 33756-33765 Chemical denotes Anaferine
628 33785-33797 Chemical denotes Withasomnine MESH:C568582
629 33818-33826 Chemical denotes Losartan
630 33847-33859 Chemical denotes Procainamide MESH:D011342
631 33880-33890 Chemical denotes Cinacalcet MESH:D000069449
632 33911-33918 Chemical denotes Arbidol MESH:C086979
633 33939-33957 Chemical denotes Hydroxychloroquine MESH:D006886
634 33978-33988 Chemical denotes Oberadilol
635 34009-34019 Chemical denotes Poziotinib MESH:C557213
637 34159-34161 Species denotes WS Tax:126910
641 34194-34202 Disease denotes toxicity MESH:D064420
640 34257-34262 Species denotes Human Tax:9606
650 34520-34522 Species denotes WS Tax:126910
651 34587-34595 Chemical denotes Losartan
652 34597-34609 Chemical denotes Procainamide MESH:D011342
653 34611-34621 Chemical denotes Cinacalcet MESH:D000069449
654 34623-34630 Chemical denotes Arbidol MESH:C086979
655 34632-34650 Chemical denotes Hydroxychloroquine MESH:D006886
656 34652-34662 Chemical denotes Oberadilol
657 34664-34674 Chemical denotes Poziotinib MESH:C557213
660 34686-34691 Species denotes Human Tax:9606
661 34878-34886 Disease denotes toxicity MESH:D064420
663 36694-36699 Species denotes Human Tax:9606
667 36800-36802 Species denotes WS Tax:126910
666 36934-36939 Species denotes human Tax:9606
669 36960-36966 Chemical denotes Caco-2
682 36992-36997 Species denotes human Tax:9606
693 36998-37021 Disease denotes colon epithelial cancer MESH:D015179
683 37059-37064 Species denotes human Tax:9606
685 37149-37158 Chemical denotes anaferine
686 37163-37175 Chemical denotes withasomnine MESH:C568582
687 37214-37220 Chemical denotes Caco-2
684 37255-37257 Species denotes WS Tax:126910
688 37341-37353 Chemical denotes procainamide MESH:D011342
689 37355-37365 Chemical denotes cinacalcet MESH:D000069449
690 37367-37374 Chemical denotes arbidol MESH:C086979
691 37379-37397 Chemical denotes hydroxychloroquine MESH:D006886
692 37446-37452 Chemical denotes Caco-2
698 37611-37613 Species denotes WS Tax:126910
699 37686-37699 Chemical denotes withanolide E
700 37743-37751 Chemical denotes losartan MESH:D019808
701 37762-37771 Disease denotes inability MESH:D007319
705 37864-37866 Species denotes WS Tax:126910
706 37969-37976 Chemical denotes arbidol MESH:C086979
707 37981-37999 Chemical denotes hydroxychloroquine MESH:D006886
709 38097-38099 Species denotes WS Tax:126910
770 38191-38193 Species denotes WS Tax:126910
758 38234-38239 Species denotes human Tax:9606
752 38240-38244 Gene denotes ACE2 Gene:59272
759 38255-38263 Species denotes SARS-CoV Tax:694009
760 38268-38278 Species denotes SARS-CoV-2 Tax:2697049
761 38332-38342 Species denotes SARS-CoV-2 Tax:2697049
771 38624-38626 Species denotes WS Tax:126910
762 38670-38675 Species denotes human Tax:9606
753 38676-38680 Gene denotes ACE2 Gene:59272
763 38691-38694 Species denotes SAR Tax:2698737
764 38695-38698 Species denotes CoV Tax:11118
765 38703-38713 Species denotes SARS-CoV-2 Tax:2697049
757 38714-38719 Gene denotes spike Gene:43740568
766 38758-38768 Species denotes SARS-CoV-2 Tax:2697049
775 38784-38791 Chemical denotes 3CL-pro
756 38796-38802 Gene denotes PL-pro Gene:43740578
772 38829-38831 Species denotes WS Tax:126910
773 39180-39182 Species denotes WS Tax:126910
774 39374-39376 Species denotes WS Tax:126910
767 39403-39408 Species denotes human Tax:9606
754 39409-39413 Gene denotes ACE2 Gene:59272
776 39446-39457 Chemical denotes withanolide MESH:D054358
777 39462-39473 Chemical denotes withanolide MESH:D054358
778 39478-39489 Chemical denotes withanolide MESH:D054358
779 39494-39508 Chemical denotes viscosalactone
780 39513-39523 Chemical denotes withaferin
781 39528-39537 Chemical denotes anaferine
782 39540-39551 Chemical denotes withanolide MESH:D054358
783 39556-39565 Chemical denotes withanone MESH:C560597
784 39568-39580 Chemical denotes withasomnine MESH:C568582
768 39634-39639 Species denotes human Tax:9606
755 39640-39644 Gene denotes ACE2 Gene:59272
785 39664-39666 Chemical denotes BE
786 39740-39747 Chemical denotes arbidol MESH:C086979
787 39758-39760 Chemical denotes BE
788 39796-39804 Chemical denotes losartan MESH:D019808
769 39921-39931 Species denotes SARS-CoV-2 Tax:2697049
789 39942-39944 Chemical denotes BE
790 39990-40002 Chemical denotes procainamide MESH:D011342
791 40013-40015 Chemical denotes BE
792 40051-40061 Chemical denotes cinacalcet MESH:D000069449
793 40072-40074 Chemical denotes BE
801 40136-40138 Species denotes WS Tax:126910
800 40162-40167 Species denotes human Tax:9606
799 40168-40172 Gene denotes ACE2 Gene:59272
802 40257-40264 Chemical denotes Arbidol MESH:C086979
803 40269-40277 Chemical denotes Losartan
813 45309-45311 Species denotes WS Tax:126910
812 45335-45343 Species denotes SARS-CoV Tax:694009
811 45344-45349 Gene denotes spike Gene:43740568
810 45364-45367 Gene denotes PDB Gene:5131
814 45438-45445 Chemical denotes Arbidol MESH:C086979
815 45450-45468 Chemical denotes Hydroxychloroquine MESH:D006886
835 49686-49688 Species denotes WS Tax:126910
834 49712-49722 Species denotes SARS-CoV-2 Tax:2697049
833 49723-49728 Gene denotes spike Gene:43740568
836 49812-49819 Chemical denotes Arbidol MESH:C086979
837 49824-49842 Chemical denotes Hydroxychloroquine MESH:D006886
862 50273-50279 CellLine denotes Leu293 CVCL:D293
852 51028-51039 Chemical denotes Withanolide MESH:D054358
853 51058-51064 Chemical denotes Gln957
854 51066-51072 Chemical denotes Thr961
855 51074-51080 Chemical denotes Lys964
856 51082-51088 Chemical denotes Gln965
857 51090-51096 Chemical denotes Ser967
858 51098-51104 Chemical denotes Ser968
859 51106-51112 Chemical denotes Leu303
860 51114-51120 Chemical denotes Lys304
861 51122-51128 Chemical denotes Thr302
863 51566-51572 CellLine denotes Leu293 CVCL:D293
864 53077-53083 CellLine denotes Leu293 CVCL:D293
865 53342-53348 CellLine denotes Leu293 CVCL:D293
873 53547-53549 Species denotes WS Tax:126910
872 53597-53607 Species denotes SARS-CoV-2 Tax:2697049
871 53609-53612 Gene denotes PDB Gene:5131
874 53683-53695 Chemical denotes Procainamide MESH:D011342
875 53700-53710 Chemical denotes Cinacalcet MESH:D000069449
881 57161-57163 Species denotes WS Tax:126910
880 57187-57195 Species denotes SARS–CoV Tax:694009
882 57293-57303 Chemical denotes Oberadilol
883 57308-57318 Chemical denotes Poziotinib MESH:C557213
891 61320-61322 Species denotes WS Tax:126910
890 61346-61356 Species denotes SARS-CoV-2 Tax:2697049
889 61380-61383 Gene denotes PDB Gene:5131
892 61454-61464 Chemical denotes Oberadilol
893 61469-61479 Chemical denotes Poziotinib MESH:C557213
901 65445-65447 Species denotes WS Tax:126910
900 65498-65508 Species denotes SARS-CoV-2 Tax:2697049
899 65510-65513 Gene denotes PDB Gene:5131
902 65584-65592 Chemical denotes Losartan
903 65597-65615 Chemical denotes Hydroxychloroquine MESH:D006886
919 70181-70184 Gene denotes PDB Gene:5131
920 70393-70403 Species denotes SARS-CoV-2 Tax:2697049
918 70427-70430 Gene denotes PDB Gene:5131
926 70456-70463 Chemical denotes 3CL-pro
921 70530-70538 Species denotes SARS-CoV Tax:694009
922 70543-70553 Species denotes SARS-CoV-2 Tax:2697049
923 70745-70755 Species denotes SARS-CoV-2 Tax:2697049
927 70771-70787 Chemical denotes viscosalactone B
916 70919-70925 Gene denotes PL-pro Gene:43740578
924 70930-70935 Species denotes human Tax:9606
917 70936-70940 Gene denotes ACE2 Gene:59272
925 70956-70958 Species denotes WS Tax:126910
961 71085-71093 Species denotes SARS-CoV Tax:694009
960 71094-71099 Gene denotes spike Gene:43740568
962 71158-71168 Species denotes SARS-CoV-2 Tax:2697049
958 71169-71174 Gene denotes spike Gene:43740568
963 71232-71240 Species denotes SARS-CoV Tax:694009
964 71312-71322 Species denotes SARS-CoV-2 Tax:2697049
955 71323-71328 Gene denotes Nsp10 Gene:43740578
956 71329-71332 Gene denotes Nsp Gene:43740578
968 71406-71419 Chemical denotes withanolide A
965 71469-71477 Species denotes SARS-CoV Tax:694009
969 71532-71539 Chemical denotes arbidol MESH:C086979
970 71550-71552 Chemical denotes BE
971 71589-71607 Chemical denotes hydroxychloroquine MESH:D006886
972 71618-71620 Chemical denotes BE
973 71696-71709 Chemical denotes withanolide A
966 71726-71736 Species denotes SARS-CoV-2 Tax:2697049
959 71737-71742 Gene denotes spike Gene:43740568
974 71796-71803 Chemical denotes arbidol MESH:C086979
975 71814-71816 Chemical denotes BE
976 71851-71869 Chemical denotes hydroxychloroquine MESH:D006886
977 71880-71882 Chemical denotes BE
978 71915-71928 Chemical denotes Withanolide A
957 71972-71978 Gene denotes Nsp-10 Gene:43740578
967 71999-72009 Species denotes SARS-CoV-2 Tax:2697049
979 72027-72035 Chemical denotes losartan MESH:D019808
980 72047-72049 Chemical denotes BE
981 72085-72103 Chemical denotes hydroxychloroquine MESH:D006886
1014 72150-72159 Chemical denotes Withanone MESH:C560597
1007 72198-72208 Species denotes SARS-Cov-2 Tax:2697049
1015 72309-72319 Chemical denotes oberadilol
1011 72396-72398 Species denotes WS Tax:126910
1008 72437-72442 Species denotes human Tax:9606
999 72443-72447 Gene denotes ACE2 Gene:59272
1012 72553-72555 Species denotes WS Tax:126910
1005 72580-72585 Gene denotes spike Gene:43740568
1009 72619-72629 Species denotes SARS-CoV-2 Tax:2697049
1006 72631-72634 Gene denotes PDB Gene:5131
1013 72660-72662 Species denotes WS Tax:126910
1010 72686-72696 Species denotes SARS-CoV-2 Tax:2697049
1004 72697-72702 Gene denotes spike Gene:43740568
1000 72744-72748 Gene denotes ACE2 Gene:59272
1003 72796-72799 Gene denotes ST1 Gene:6386
1001 72806-72809 Gene denotes ST2 Gene:6761
1002 72814-72817 Gene denotes SF2 Gene:6426
1018 72866-72871 Species denotes human Tax:9606
1019 72912-72914 Species denotes WS Tax:126910
1127 73017-73019 Species denotes WS Tax:126910
1120 73043-73048 Species denotes human Tax:9606
1112 73049-73053 Gene denotes ACE2 Gene:59272
1134 73138-73145 Chemical denotes Arbidol MESH:C086979
1135 73150-73158 Chemical denotes Losartan
1136 73160-73172 Chemical denotes Withaferin A
1137 73173-73186 Chemical denotes Withanolide A
1138 73187-73198 Chemical denotes Withanolide MESH:D054358
1139 73201-73212 Chemical denotes Withanolide MESH:D054358
1140 73215-73226 Chemical denotes Withanolide MESH:D054358
1141 73229-79421 Chemical denotes Withanone Viscosalactone B Anaferine Withasomnine Arbidol Losartan 12.2. Best docking poses of WS phytoconstituents with SARS-CoV spike glycoprotein (PDB ID: 5WRG) in comparison to the FDA approved standard reference drugs (Arbidol and Hydroxychloroquine) Withaferin A Withanolide A Withanolide B Withanolide D Withanolide E Withanone Viscosalactone B Anaferine Withasomnine Arbidol Hydroxychloroquine 12.3. Best docking poses of WS phytoconstituents with SARS-CoV-2 spike glycoprotein (PDB ID: 6VXX) in comparison to FDA approved standard reference drugs (Arbidol and Hydroxychloroquine) Withaferin A Withanolide A Withanolide B Withanolide D Withanolide E Withanone Viscosalactone B Anaferine Withasomnine Arbidol Hydroxychloroquine 12.4. Best docking poses of WS phytoconstituents with papain like protease of SARS-CoV-2 (PDB ID: 6W9C) in comparison to the FDA approved standard reference drugs (Procainamide and Cinacalcet) Withaferin A Withanolide A Withanolide B Withanolide D Withanolide E Withanone Viscosalactone B Anaferine Withasomnine Procainamide Cinacalcet 12.5. Best docking poses of WS phytoconstituents with SARS-CoV main protease/3CL-pro (PBB ID: 1P9U) in comparison to the FDA approved standard reference drugs (Oberadilol and Poziotinib) Withaferin A Withanolide A Withanolide B Withanolide D Withanolide E Withanone Viscosalactone B Anaferine Withasomnine Oberadilol Poziotinib 12.6. Best docking poses of WS phytoconstituents with SARS-CoV-2 main protease/3CL-pro (PDB ID: 6LU7) in comparison to the FDA approved standard reference drugs (Oberadilol and Poziotinib) Withaferin A Withanolide A Withanolide B Withanolide D Withanolide E Withanone Viscosalactone B Anaferine Withasomnine Oberadilol Poziotinib 12.7. Best docking poses of WS phytoconstituents with Nsp-10/Nsp-16 complex from SARS-CoV-2 (PDB ID: 6W75) in comparison to the FDA approved standard reference drugs (Losartan and Hydroxychloroquine) Withaferin A Withanolide A Withanolide B Withanolide D Withanolide E Withanone Viscosalactone B Anaferine Withasomnine Losartan Hydroxychloroquine 3.4. Bioavailability radar and score as parameters for analysis of pharmacokinetic properties of WS phytoconstituents Pharmacokinetics and pharmacodynamics are two interlinked terms in drug development having a mutual influence on each other. Bioavailability radar offers a first glimpse into the pharmaceutical properties of a prospective drug candidate. By convention, the pink area represents the optimal biological range for each physiochemical property including lipophilicity (XLOGP3 range 0.7–5.0), size (MW range 150–500), polarity (TPSA range 20–130 Å2), solubility (log S ≤ 6), saturation (fraction of carbons in sp3 hybridization ≤0.25), and flexibility (≤9). The Abbot Bioavailability Score62 is identical, but attempts to determine whether a compound is likely to have oral bioavailability score of at least 10% in rats and/or Caco-2 permeability (Martin, 2005). As is evident from Figure 2A and B, all withanolides from WS exhibited a significant bioavailability radar and score as comparable to the standard reference FDA-approved drugs. Figure 2. (A) Bioavailability radar and score prediction of WS phytoconstituents using SwissADME. (B) Bioavailability radar and score prediction of FDA–approved reference standard drugs using SwissADME. 3.5. Druglikeness and Bioactivity score (BAS) analysis Biological targets of prospective drug candidates can be classified into ion channels, proteases, kinases, G-protein coupled receptors (GPCRs), nuclear receptors and enzymes. The BAS of WS phytoconstituents was determined using web-based software Molinspiration (www.molinspiration.com). As a general rule, it is known that if the BAS > 0.0, then the drug candidate is physiologically active; if it is in the range −5.0 to 0.0; then the drug candidate is moderately active, and if the BAS< −5.0, then the drug candidate is inactive. It is evident from Table 13, that most of the WS phytoconstituents had positive values with respect to the following receptors. 3.5.1. As GPCR ligands All WS phytoconstituents were active except withanolide E, anaferine and withasomnine which were predicted to be moderatively active. Most of the reference drugs also had positive values for GPCR except procainamide and arbidol which were predicted to be moderately active. 3.5.2. As ICMs All WS phytoconstituents had positive values except withasomnine which was found to be moderately active. Standard reference drugs losartan, cinacalcet, hydroxychloroquine, oberadilol and poziotinib were all found to be active whereas procainamide and arbidol were found to be moderately active. 3.5.3. As KIs All WS phytoconstituents displayed moderate activity except withasomnine that displayed significant activity. Standard reference drugs losartan, hydroxychloroquine and poziotinib were found to be active whereas procainamide, cinacalcet, arbidol and oberadilol were found to be moderately active. 3.5.4. As NRLs Withaferin A, withanolides A, B, D and E, withanone and viscosalactone B possessed significant BAS scores whereas anaferine and withasomnine were found to be moderately active. All standard reference drugs were predicted to have moderate BAS scores as NRLs. 3.5.5. As PIs Withaferin A, withanolides A, B, D and E, withanone and viscosalactone B had positive BAS scores indicating their potential as protease inhibitors. On the other hand, anaferine and withasomnine were found to have moderate activity as protease inhibitors. Interestingly, most withanolides especially withanolide B and withanolide A showed potent binding to papain like protease of SARS-CoV-2 (PDB ID: 6W9C), SARS-CoV 3CL-pro main protease (PDB ID: IP9U) and SARS-CoV-2 Nsp10/Nsp-16 complex (PDB ID: 6W75) thus supporting their role as potential viral protease inhibitors. On the other hand, losartan, cinacalcet and hydroxychloroquine also displayed positive values as protease inhibitors whereas procainamide, arbidol, oberadilol and poziotinib displayed moderate potential as protease inhibitors. 3.5.6. As EIs Most of the WS phytoconstituents including Withaferin A, withanolides A, B, D and E, withanone, viscosalactone
1205 75404-75406 Species denotes WS Tax:126910
1213 75919-75926 Chemical denotes carbons MESH:D002244
1211 76135-76139 Species denotes rats Tax:10116
1214 76147-76153 Chemical denotes Caco-2
1215 76223-76235 Chemical denotes withanolides MESH:D054358
1212 76241-76243 Species denotes WS Tax:126910
1217 76421-76423 Species denotes WS Tax:126910
1219 76807-76809 Species denotes WS Tax:126910
1221 77200-77202 Species denotes WS Tax:126910
1228 77311-77313 Species denotes WS Tax:126910
1229 77351-77364 Chemical denotes withanolide E
1230 77366-77375 Chemical denotes anaferine
1231 77380-77392 Chemical denotes withasomnine MESH:C568582
1232 77510-77522 Chemical denotes procainamide MESH:D011342
1233 77527-77534 Chemical denotes arbidol MESH:C086979
1235 77593-77597 Disease denotes ICMs
1245 77602-77604 Species denotes WS Tax:126910
1246 77650-77662 Chemical denotes withasomnine MESH:C568582
1247 77729-77737 Chemical denotes losartan MESH:D019808
1248 77739-77749 Chemical denotes cinacalcet MESH:D000069449
1249 77751-77769 Chemical denotes hydroxychloroquine MESH:D006886
1250 77771-77781 Chemical denotes oberadilol
1251 77786-77796 Chemical denotes poziotinib MESH:C557213
1252 77833-77845 Chemical denotes procainamide MESH:D011342
1253 77850-77857 Chemical denotes arbidol MESH:C086979
1263 77914-77916 Species denotes WS Tax:126910
1264 77970-77982 Chemical denotes withasomnine MESH:C568582
1265 78045-78053 Chemical denotes losartan MESH:D019808
1266 78055-78073 Chemical denotes hydroxychloroquine MESH:D006886
1267 78078-78088 Chemical denotes poziotinib MESH:C557213
1268 78121-78133 Chemical denotes procainamide MESH:D011342
1269 78135-78145 Chemical denotes cinacalcet MESH:D000069449
1270 78147-78154 Chemical denotes arbidol MESH:C086979
1271 78159-78169 Chemical denotes oberadilol
1279 78223-78235 Chemical denotes Withaferin A
1280 78237-78249 Chemical denotes withanolides MESH:D054358
1281 78251-78263 Chemical denotes , B, D and E
1282 78265-78274 Chemical denotes withanone MESH:C560597
1283 78279-78293 Chemical denotes viscosalactone
1284 78337-78346 Chemical denotes anaferine
1285 78351-78363 Chemical denotes withasomnine MESH:C568582
1317 78497-78509 Chemical denotes Withaferin A
1318 78511-78523 Chemical denotes withanolides MESH:D054358
1319 78539-78548 Chemical denotes withanone MESH:C560597
1320 78553-78567 Chemical denotes viscosalactone
1321 78664-78673 Chemical denotes anaferine
1322 78678-78690 Chemical denotes withasomnine MESH:C568582
1323 78772-78784 Chemical denotes withanolides MESH:D054358
1324 78814-78827 Chemical denotes withanolide A
1314 78877-78887 Species denotes SARS-CoV-2 Tax:2697049
1313 78889-78892 Gene denotes PDB Gene:5131
1315 78904-78912 Species denotes SARS-CoV Tax:694009
1312 78936-78939 Gene denotes PDB Gene:5131
1316 78954-78964 Species denotes SARS-CoV-2 Tax:2697049
1309 78965-78970 Gene denotes Nsp10 Gene:43740578
1310 78971-78974 Gene denotes Nsp Gene:43740578
1311 78987-78990 Gene denotes PDB Gene:5131
1325 79087-79095 Chemical denotes losartan MESH:D019808
1326 79097-79107 Chemical denotes cinacalcet MESH:D000069449
1327 79112-79130 Chemical denotes hydroxychloroquine MESH:D006886
1328 79193-79205 Chemical denotes procainamide MESH:D011342
1329 79207-79214 Chemical denotes arbidol MESH:C086979
1330 79216-79226 Chemical denotes oberadilol
1331 79231-79241 Chemical denotes poziotinib MESH:C557213
1364 79323-79325 Species denotes WS Tax:126910
1366 79354-79366 Chemical denotes Withaferin A
1367 79368-79394 Chemical denotes withanolides A, B, D and E
1368 79396-79405 Chemical denotes withanone MESH:C560597
1369 79699-79715 Chemical denotes viscosalactone B
1370 79720-79729 Chemical denotes anaferine
1145 79885-79892 Chemical denotes arbidol MESH:C086979
1371 80245-80269 Chemical denotes procainamide and arbidol MESH:C568582
1394 80415-80417 Species denotes WS Tax:126910
1147 80547-80557 Chemical denotes Withaferin
1396 80561-80572 Chemical denotes withanolide MESH:D054358
1398 80597-80609 Chemical denotes withasomnine MESH:C568582
1399 80774-80786 Chemical denotes procainamide MESH:D011342
1400 80788-80806 Chemical denotes hydroxychloroquine MESH:D006886
1401 80811-80821 Chemical denotes oberadilol
1410 80927-80929 Species denotes WS Tax:126910
1411 80994-81002 Chemical denotes Losartan
1412 81004-81016 Chemical denotes Procainamide MESH:D011342
1413 81018-81028 Chemical denotes Cinacalcet MESH:D000069449
1414 81030-81037 Chemical denotes Arbidol MESH:C086979
1415 81039-81057 Chemical denotes Hydroxychloroquine MESH:D006886
1416 81059-81069 Chemical denotes Oberadilol
1417 81071-81081 Chemical denotes Poziotinib MESH:C557213
1434 81308-81320 Chemical denotes Withaferin A
1435 81365-81376 Chemical denotes Withanolide MESH:D054358
1436 81423-81434 Chemical denotes Withanolide MESH:D054358
1437 81481-81492 Chemical denotes Withanolide MESH:D054358
1438 81539-81550 Chemical denotes Withanolide MESH:D054358
1439 81598-81607 Chemical denotes Withanone MESH:C560597
1440 81652-81666 Chemical denotes Viscosalactone
1441 81713-81722 Chemical denotes Anaferine
1442 81770-81782 Chemical denotes Withasomnine MESH:C568582
1443 81832-81840 Chemical denotes Losartan
1444 81885-81897 Chemical denotes Procainamide MESH:D011342
1445 81947-81957 Chemical denotes Cinacalcet MESH:D000069449
1446 82004-82011 Chemical denotes Arbidol MESH:C086979
1447 82062-82080 Chemical denotes Hydroxychloroquine MESH:D006886
1448 82126-82136 Chemical denotes Oberadilol
1449 82185-82195 Chemical denotes Poziotinib MESH:C557213
1451 82352-82360 Disease denotes Toxicity MESH:D064420
1458 82555-82563 Disease denotes toxicity MESH:D064420
1459 82777-82785 Disease denotes toxicity MESH:D064420
1460 82907-82915 Disease denotes toxicity MESH:D064420
1457 82935-82937 Species denotes WS Tax:126910
1461 83025-83033 Disease denotes toxicity MESH:D064420
1472 83311-83313 Species denotes WS Tax:126910
1475 83398-83416 Chemical denotes hydroxychloroquine MESH:D006886
1476 83421-83431 Chemical denotes poziotinib MESH:C557213
1473 83479-83481 Species denotes WS Tax:126910
1477 83580-83590 Chemical denotes cinacalcet MESH:D000069449
1478 83595-83605 Chemical denotes oberadilol
1479 83661-83671 Chemical denotes poziotinib MESH:C557213
1474 83756-83758 Species denotes WS Tax:126910
1480 83868-83880 Chemical denotes procainamide MESH:D011342
1481 83937-83947 Chemical denotes poziotinib MESH:C557213
1490 84050-84052 Species denotes WS Tax:126910
1491 84117-84125 Chemical denotes Losartan
1492 84127-84139 Chemical denotes Procainamide MESH:D011342
1493 84141-84151 Chemical denotes Cinacalcet MESH:D000069449
1494 84153-84160 Chemical denotes Arbidol MESH:C086979
1495 84162-84180 Chemical denotes Hydroxychloroquine MESH:D006886
1496 84182-84192 Chemical denotes Oberadilol
1497 84194-84204 Chemical denotes Poziotinib MESH:C557213
1514 84256-84268 Chemical denotes Withaferin A
1515 84289-84302 Chemical denotes Withanolide A
1516 84324-84335 Chemical denotes Withanolide MESH:D054358
1517 84359-84370 Chemical denotes Withanolide MESH:D054358
1518 84393-84404 Chemical denotes Withanolide MESH:D054358
1519 84428-84437 Chemical denotes Withanone MESH:C560597
1520 84459-84475 Chemical denotes Viscosalactone B
1521 84496-84505 Chemical denotes Anaferine
1522 84527-84539 Chemical denotes Withasomnine MESH:C568582
1523 84561-84569 Chemical denotes Losartan
1524 84592-84604 Chemical denotes Procainamide MESH:D011342
1525 84626-84636 Chemical denotes Cinacalcet MESH:D000069449
1526 84659-84671 Chemical denotes Arbidol –1.
1527 84689-84707 Chemical denotes Hydroxychloroquine MESH:D006886
1528 84729-84739 Chemical denotes Oberadilol
1529 84761-84771 Chemical denotes Poziotinib MESH:C557213
1533 85385-85397 Chemical denotes withanolides MESH:D054358
1532 85473-85479 Species denotes humans Tax:9606
1542 85546-85548 Species denotes WS Tax:126910
1543 85613-85621 Chemical denotes Losartan
1544 85623-85635 Chemical denotes Procainamide MESH:D011342
1545 85637-85647 Chemical denotes Cinacalcet MESH:D000069449
1546 85649-85656 Chemical denotes Arbidol MESH:C086979
1547 85658-85676 Chemical denotes Hydroxychloroquine MESH:D006886
1548 85678-85688 Chemical denotes Oberadilol
1549 85690-85700 Chemical denotes Poziotinib MESH:C557213
1551 85764-85766 Species denotes WS Tax:126910
1554 86736-86738 Species denotes WS Tax:126910
1555 86950-86952 Species denotes WS Tax:126910
1564 87127-87129 Species denotes WS Tax:126910
1565 87194-87202 Chemical denotes Losartan
1566 87204-87216 Chemical denotes Procainamide MESH:D011342
1567 87218-87228 Chemical denotes Cinacalcet MESH:D000069449
1568 87230-87237 Chemical denotes Arbidol MESH:C086979
1569 87239-87257 Chemical denotes Hydroxychloroquine MESH:D006886
1570 87259-87269 Chemical denotes Oberadilol
1571 87271-87281 Chemical denotes Poziotinib MESH:C557213
1573 87346-87349 Species denotes SAR Tax:2698737
1602 87351-87353 Species denotes WS Tax:126910
1604 87433-87443 Chemical denotes terpenoids MESH:D013729
1605 87445-87455 Chemical denotes flavonoids MESH:D005419
1606 87457-87464 Chemical denotes tannins MESH:D013634
1607 87488-87500 Chemical denotes Withanolides MESH:D054358
1608 87502-87511 Chemical denotes alkaloids MESH:D000470
1609 87513-87523 Chemical denotes flavonoids MESH:D005419
1610 87528-87535 Chemical denotes tannins MESH:D013634
1611 87677-87689 Chemical denotes withanolides MESH:D054358
1612 87908-87920 Chemical denotes withanolides MESH:D054358
1613 87927-87938 Chemical denotes withanolide MESH:D054358
1614 87959-87968 Chemical denotes withanone MESH:C560597
1603 87972-87974 Species denotes WS Tax:126910
1615 88022-88033 Chemical denotes withanolide MESH:D054358
1616 88067-88079 Chemical denotes withanolides MESH:D054358
1617 88138-88145 Chemical denotes lactone MESH:D007783
1618 88146-88159 Chemical denotes triterpenoids MESH:D014315
1619 88200-88209 Chemical denotes ergostane MESH:C015190
1620 88230-88231 Chemical denotes C MESH:D002244
1621 88239-88240 Chemical denotes C MESH:D002244
1622 88280-88287 Chemical denotes lactone MESH:D007783
1623 88318-88329 Chemical denotes withanolide MESH:D054358
1624 88367-88399 Chemical denotes 22-hydroxy ergostane-26-oic acid
1625 88404-88414 Chemical denotes 22-lactone
1626 88445-88457 Chemical denotes withanolides MESH:D054358
1627 88477-88483 Chemical denotes oxygen MESH:D010100
1628 88545-88551 Chemical denotes carbon MESH:D002244
1629 88563-88570 Chemical denotes steroid MESH:D013256
1642 88608-88620 Chemical denotes withanolides MESH:D054358
1643 88625-88634 Chemical denotes ergostane MESH:C015190
1644 88640-88648 Chemical denotes steroids MESH:D013256
1645 88714-88721 Chemical denotes lactone MESH:D007783
1646 88725-88731 Chemical denotes lactol
1647 88740-88746 Chemical denotes carbon MESH:D002244
1648 88747-88753 Chemical denotes carbon MESH:D002244
1649 88762-88768 Chemical denotes oxygen MESH:D010100
1650 88808-88815 Chemical denotes lactone MESH:D007783
1651 88889-88901 Chemical denotes Withanolides MESH:D054358
1652 89042-89054 Chemical denotes withanolides MESH:D054358
1653 89330-89342 Chemical denotes withanolides MESH:D054358
1671 89433-89446 Chemical denotes withanolide A
1672 89448-89456 Chemical denotes C28H38O6
1673 89474-89482 Chemical denotes C28H38O5
1674 89485-89498 Chemical denotes withanolide E
1675 89500-89508 Chemical denotes C28H38O7
1676 89514-89523 Chemical denotes withanone MESH:C560597
1677 89525-89533 Chemical denotes C28H38O7
1678 89580-89586 Chemical denotes oxygen MESH:D010100
1679 89632-89640 Chemical denotes hydrogen MESH:D006859
1670 89736-89739 Species denotes SAR Tax:2698737
1680 89763-89775 Chemical denotes withanolides MESH:D054358
1681 89854-89860 Chemical denotes oxygen MESH:D010100
1682 90067-90079 Chemical denotes withanolides MESH:D054358
1683 90083-90092 Chemical denotes ergostane MESH:C015190
1684 90098-90106 Chemical denotes steroids MESH:D013256
1685 90170-90181 Chemical denotes withanolide MESH:D054358
1692 90351-90362 Chemical denotes Withanolide MESH:D054358
1693 90384-90395 Chemical denotes Withanolide MESH:D054358
1694 90416-90429 Chemical denotes Withanolide E
1695 90435-90443 Chemical denotes 6β–epoxy
1696 90449-90458 Chemical denotes Withanone MESH:C560597
1697 90460-90466 Chemical denotes 17α–OH
1706 91146-91148 Species denotes WS Tax:126910
1707 91213-91221 Chemical denotes Losartan
1708 91223-91235 Chemical denotes Procainamide MESH:D011342
1709 91237-91247 Chemical denotes Cinacalcet MESH:D000069449
1710 91249-91256 Chemical denotes Arbidol MESH:C086979
1711 91258-91276 Chemical denotes Hydroxychloroquine MESH:D006886
1712 91278-91288 Chemical denotes Oberadilol
1713 91290-91300 Chemical denotes Poziotinib MESH:C557213
1722 91373-91375 Species denotes WS Tax:126910
1723 91440-91448 Chemical denotes Losartan
1724 91450-91462 Chemical denotes Procainamide MESH:D011342
1725 91464-91474 Chemical denotes Cinacalcet MESH:D000069449
1726 91476-91483 Chemical denotes Arbidol MESH:C086979
1727 91485-91503 Chemical denotes Hydroxychloroquine MESH:D006886
1728 91505-91515 Chemical denotes Oberadilol
1729 91517-91527 Chemical denotes Poziotinib MESH:C557213
1738 91616-91618 Species denotes WS Tax:126910
1739 91684-91692 Chemical denotes Losartan
1740 91694-91706 Chemical denotes Procainamide MESH:D011342
1741 91708-91718 Chemical denotes Cinacalcet MESH:D000069449
1742 91720-91727 Chemical denotes Arbidol MESH:C086979
1743 91729-91747 Chemical denotes Hydroxychloroquine MESH:D006886
1744 91749-91759 Chemical denotes Oberadilol
1745 91761-91771 Chemical denotes Poziotinib MESH:C557213
1763 91821-91829 Disease denotes Toxicity MESH:D064420
1755 91849-91851 Species denotes WS Tax:126910
1756 91916-91924 Chemical denotes Losartan
1757 91926-91938 Chemical denotes Procainamide MESH:D011342
1758 91940-91950 Chemical denotes Cinacalcet MESH:D000069449
1759 91952-91959 Chemical denotes Arbidol MESH:C086979
1760 91961-91979 Chemical denotes Hydroxychloroquine MESH:D006886
1761 91981-91991 Chemical denotes Oberadilol
1762 91993-92003 Chemical denotes Poziotinib MESH:C557213
1779 92084-92096 Chemical denotes Withaferin A
1780 92125-92138 Chemical denotes Withanolide A
1781 92209-92220 Chemical denotes Withanolide MESH:D054358
1782 92251-92262 Chemical denotes Withanolide MESH:D054358
1783 92293-92302 Chemical denotes Withanone MESH:C560597
1784 92331-92347 Chemical denotes Viscosalactone B
1785 92376-92385 Chemical denotes Anaferine
1786 92414-92426 Chemical denotes Withasomnine MESH:C568582
1787 92456-92464 Chemical denotes Losartan
1788 92494-92506 Chemical denotes Procainamide MESH:D011342
1789 92536-92546 Chemical denotes Cinacalcet MESH:D000069449
1790 92576-92583 Chemical denotes Arbidol MESH:C086979
1791 92613-92631 Chemical denotes Hydroxychloroquine MESH:D006886
1792 92661-92671 Chemical denotes Oberadilol
1793 92701-92711 Chemical denotes Poziotinib MESH:C557213
1796 92772-92774 Species denotes WS Tax:126910
1797 93003-93005 Species denotes WS Tax:126910
1806 93133-93135 Species denotes WS Tax:126910
1807 93200-93208 Chemical denotes Losartan
1808 93210-93222 Chemical denotes Procainamide MESH:D011342
1809 93224-93234 Chemical denotes Cinacalcet MESH:D000069449
1810 93236-93243 Chemical denotes Arbidol MESH:C086979
1811 93245-93263 Chemical denotes Hydroxychloroquine MESH:D006886
1812 93265-93275 Chemical denotes Oberadilol
1813 93277-93287 Chemical denotes Poziotinib MESH:C557213
1819 94423-94426 Gene denotes pc1 Gene:7163
1818 94564-94567 Gene denotes pc2 Gene:3854
1817 94714-94717 Gene denotes pc3 Gene:3853
1828 95699-95701 Species denotes WS Tax:126910
1829 95766-95774 Chemical denotes Losartan
1830 95776-95788 Chemical denotes Procainamide MESH:D011342
1831 95790-95800 Chemical denotes Cinacalcet MESH:D000069449
1832 95802-95809 Chemical denotes Arbidol MESH:C086979
1833 95811-95829 Chemical denotes Hydroxychloroquine MESH:D006886
1834 95831-95841 Chemical denotes Oberadilol
1835 95843-95853 Chemical denotes Poziotinib MESH:C557213
1841 96079-96082 Gene denotes pc1 Gene:7163
1840 96132-96135 Gene denotes pc2 Gene:3854
1839 96185-96188 Gene denotes pc3 Gene:3853
1850 96302-96304 Species denotes WS Tax:126910
1851 96369-96377 Chemical denotes Losartan
1852 96379-96391 Chemical denotes Procainamide MESH:D011342
1853 96393-96403 Chemical denotes Cinacalcet MESH:D000069449
1854 96405-96412 Chemical denotes Arbidol MESH:C086979
1855 96414-96432 Chemical denotes Hydroxychloroquine MESH:D006886
1856 96434-96444 Chemical denotes Oberadilol
1857 96446-96456 Chemical denotes Poziotinib MESH:C557213
1863 96921-96924 Gene denotes pc1 Gene:7163
1862 97007-97010 Gene denotes pc2 Gene:3854
1861 97094-97097 Gene denotes pc3 Gene:3853
1885 97475-97485 Species denotes SARS-CoV-2 Tax:2697049
1882 97486-97491 Gene denotes spike Gene:43740568
1884 97517-97520 Gene denotes PDB Gene:5131
1886 97560-97570 Species denotes SARS-CoV-2 Tax:2697049
1883 97593-97596 Gene denotes PDB Gene:5131
1887 98139-98149 Species denotes SARS-CoV-2 Tax:2697049
1881 98150-98155 Gene denotes spike Gene:43740568
1893 98180-98191 Chemical denotes withanolide MESH:D054358
1888 98391-98401 Species denotes SARS-CoV-2 Tax:2697049
1889 98685-98693 Species denotes SARS-CoV Tax:694009
1880 98694-98699 Gene denotes spike Gene:43740568
1892 98714-98717 Gene denotes PDB Gene:5131
1894 98733-98744 Chemical denotes withanolide MESH:D054358
1890 98751-98761 Species denotes SARS-CoV-2 Tax:2697049
1891 98777-98780 Gene denotes PDB Gene:5131
1895 98796-98809 Chemical denotes withanolide A
1900 98846-98856 Species denotes SARS–CoV–2 Tax:2697049
1899 98857-98862 Gene denotes spike Gene:43740568
1901 98905-98918 Chemical denotes withanolide A
1912 99827-99835 Species denotes SARS–CoV Tax:694009
1909 99836-99841 Gene denotes spike Gene:43740568
1911 99856-99859 Gene denotes PDB Gene:5131
1913 100117-100127 Species denotes SARS-CoV–2 Tax:2697049
1908 100128-100134 Gene denotes PL-pro Gene:43740578
1910 100136-100139 Gene denotes PDB Gene:5131
1937 100373-100381 Species denotes SARS–CoV Tax:694009
1934 100382-100387 Gene denotes spike Gene:43740568
1936 100402-100405 Gene denotes PDB Gene:5131
1926 100551-100554 Gene denotes PC1 Gene:7163
1927 100556-100559 Gene denotes PC2 Gene:3854
1928 100564-100567 Gene denotes PC3 Gene:3853
1935 100638-100641 Gene denotes PC1 Gene:7163
1929 100643-100646 Gene denotes PC2 Gene:3854
1930 100651-100654 Gene denotes PC3 Gene:3853
1931 100971-100974 Gene denotes PC1 Gene:7163
1932 100976-100979 Gene denotes PC2 Gene:3854
1933 100984-100987 Gene denotes PC3 Gene:3853
1943 101220-101228 Species denotes SARS–CoV Tax:694009
1941 101229-101234 Gene denotes spike Gene:43740568
1942 101249-101252 Gene denotes PDB Gene:5131
1953 101681-101691 Species denotes SARS-CoV-2 Tax:2697049
1952 101707-101710 Gene denotes PDB Gene:5131
1955 101726-101739 Chemical denotes withanolide A
1954 101968-101978 Species denotes SARS-CoV-2 Tax:2697049
1950 101979-101985 Gene denotes PL-pro Gene:43740578
1951 101987-101990 Gene denotes PDB Gene:5131
1977 102224-102234 Species denotes SARS-CoV-2 Tax:2697049
1976 102250-102253 Gene denotes PDB Gene:5131
1967 102399-102402 Gene denotes PC1 Gene:7163
1968 102404-102407 Gene denotes PC2 Gene:3854
1969 102412-102415 Gene denotes PC3 Gene:3853
1975 102486-102489 Gene denotes PC1 Gene:7163
1970 102491-102494 Gene denotes PC2 Gene:3854
1971 102499-102502 Gene denotes PC3 Gene:3853
1972 102819-102822 Gene denotes PC1 Gene:7163
1973 102824-102827 Gene denotes PC2 Gene:3854
1974 102832-102835 Gene denotes PC3 Gene:3853
1983 103068-103076 Species denotes SARS-CoV Tax:694009
1981 103077-103082 Gene denotes spike Gene:43740568
1982 103097-103100 Gene denotes PDB Gene:5131
1990 104050-104060 Species denotes SARS-CoV-2 Tax:2697049
1993 104081-104101 Disease denotes zoonotic coronavirus MESH:D015047
1994 104261-104265 Disease denotes MERS MESH:D018352
1995 104486-104494 Disease denotes COVID-19 MESH:C000657245
1991 104703-104714 Species denotes coronavirus Tax:11118
1992 104828-104833 Species denotes human Tax:9606
1997 105335-105343 Disease denotes COVID-19 MESH:C000657245
2010 105524-105536 Chemical denotes Withanolides MESH:D054358
2011 105585-105593 Chemical denotes steroids MESH:D013256
2012 105606-105615 Chemical denotes ergostane MESH:C015190
2013 105728-105741 Chemical denotes triterpenoids MESH:D014315
2014 105760-105766 Chemical denotes carbon MESH:D002244
2007 105820-105822 Species denotes WS Tax:126910
2008 106045-106047 Species denotes WS Tax:126910
2009 106134-106136 Species denotes WS Tax:126910
2015 106145-106153 Disease denotes COVID-19 MESH:C000657245
2021 106668-106676 Chemical denotes hydrogen MESH:D006859
2020 106941-106943 Species denotes WS Tax:126910
2022 107004-107014 Chemical denotes cinacalcet MESH:D000069449
2023 107019-107029 Chemical denotes poziotinib MESH:C557213
2054 107269-107271 Species denotes WS Tax:126910
2055 107548-107550 Species denotes WS Tax:126910
2058 107599-107603 Chemical denotes ADME
2059 107703-107709 Chemical denotes Caco-2
2060 107724-107733 Chemical denotes anaferine
2061 107738-107750 Chemical denotes withasomnine MESH:C568582
2062 107789-107795 Chemical denotes Caco-2
2063 107831-107836 Chemical denotes Caco-
2065 108213-108227 Disease denotes genetic damage MESH:D030342
2066 108347-108361 Disease denotes carcinogenesis MESH:D063646
2056 108437-108439 Species denotes WS Tax:126910
2064 108507-108514 Chemical denotes 3CL-pro
2048 108518-108522 Species denotes CoVs Tax:11118
2067 108619-108628 Disease denotes infection MESH:D007239
2049 108876-108881 Species denotes Human Tax:9606
2046 108882-108886 Gene denotes ACE2 Gene:59272
2050 108970-108978 Species denotes SARS-CoV Tax:694009
2051 108983-108993 Species denotes SARS-CoV-2 Tax:2697049
2057 109035-109040 Gene denotes spike Gene:43740568
2052 109084-109097 Species denotes coronaviruses Tax:11118
2047 109140-109144 Gene denotes ACE2 Gene:59272
2053 109219-109232 Species denotes coronaviruses Tax:11118
2111 109375-109385 Chemical denotes Nelfinavir MESH:D019888
2112 109390-109399 Chemical denotes lopinavir MESH:D061466
2120 109443-109456 Disease denotes HIV infection MESH:D015658
2113 109509-109518 Chemical denotes Lopinavir MESH:D061466
2114 109523-109532 Chemical denotes ritonavir MESH:D019438
2121 109605-109609 Disease denotes MERS MESH:D018352
2115 109649-109659 Chemical denotes nelfinavir MESH:D019888
2116 109664-109673 Chemical denotes lopinavir MESH:D061466
2117 109767-109779 Chemical denotes withanolides MESH:D054358
2109 109789-109791 Species denotes WS Tax:126910
1361 109812-109817 Species denotes human Tax:9606
1359 109818-109822 Gene denotes ACE2 Gene:59272
2101 109833-109841 Species denotes SARS-CoV Tax:694009
2102 109846-109856 Species denotes SARS-CoV-2 Tax:2697049
2103 109960-109968 Species denotes SARS-CoV Tax:694009
2099 109969-109974 Gene denotes spike Gene:43740568
1122 110024-110034 Species denotes SARS-CoV-2 Tax:2697049
1113 110035-110040 Gene denotes spike Gene:43740568
2105 110089-110097 Species denotes SARS-CoV Tax:694009
2106 110159-110169 Species denotes SARS-CoV-2 Tax:2697049
2096 110170-110175 Gene denotes Nsp10 Gene:43740578
2097 110176-110179 Gene denotes Nsp Gene:43740578
2118 110260-110272 Chemical denotes withanolides MESH:D054358
2119 110285-110294 Chemical denotes withanone MESH:C560597
2110 110350-110352 Species denotes WS Tax:126910
2107 110446-110464 Species denotes Withania somnifera Tax:126910
2108 110620-110630 Species denotes SARS-CoV-2 Tax:2697049
2130 110722-110734 Chemical denotes withanolides MESH:D054358
1157 110740-110751 Chemical denotes withanolide MESH:D054358
1158 110755-110766 Chemical denotes withanolide MESH:D054358
2132 110773-110782 Chemical denotes withanone MESH:C560597
2134 110905-110913 Disease denotes COVID-19 MESH:C000657245
2135 110914-110923 Disease denotes infection MESH:D007239
2133 111012-111024 Chemical denotes withanolides MESH:D054358
2129 111034-111036 Species denotes WS Tax:126910