LitCovid-ArguminSci  

PubMed:32172546 JSONTXT 38 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-80 DRI_Background denotes [A pathological report of three COVID-19 cases by minimally invasive autopsies].
T2 81-277 DRI_Background denotes Objective: To investigate the pathological characteristics and the clinical significance of novel coronavirus (2019-nCoV)-infected pneumonia (termed by WHO as corona virus disease 2019, COVID-19).
T3 278-506 DRI_Background denotes Methods: Minimally invasive autopsies from lung, heart, kidney, spleen, bone marrow, liver, pancreas, stomach, intestine, thyroid and skin were performed on three patients died of novel coronavirus pneumonia in Chongqing, China.
T4 507-656 DRI_Background denotes Hematoxylin and eosin staining (HE) and histochemical staining were performed to investigate the pathological changes of indicated organs or tissues.
T5 657-793 DRI_Background denotes Immunohistochemical staining was conducted to evaluate the infiltration of immune cells as well as the expression of 2019-nCoV proteins.
T6 794-855 DRI_Approach denotes Real time PCR was carried out to detect the RNA of 2019-nCoV.
T7 856-971 DRI_Background denotes Results: Various damages were observed in the alveolar structure, with minor serous exudation and fibrin exudation.
T8 972-1028 DRI_Background denotes Hyaline membrane formation was observed in some alveoli.
T9 1029-1108 DRI_Background denotes The infiltrated immune cells in alveoli were majorly macrophages and monocytes.
T10 1109-1214 DRI_Background denotes Moderate multinucleated giant cells, minimal lymphocytes, eosinophils and neutrophils were also observed.
T11 1215-1273 DRI_Approach denotes Most of infiltrated lymphocytes were CD4-positive T cells.
T12 1274-1395 DRI_Background denotes Significant proliferation of type II alveolar epithelia and focal desquamation of alveolar epithelia were also indicated.
T13 1396-1526 DRI_Approach denotes The blood vessels of alveolar septum were congested, edematous and widened, with modest infiltration of monocytes and lymphocytes.
T14 1527-1584 DRI_Background denotes Hyaline thrombi were found in a minority of microvessels.
T15 1585-1719 DRI_Background denotes Focal hemorrhage in lung tissue, organization of exudates in some alveolar cavities, and pulmonary interstitial fibrosiswere observed.
T16 1720-1768 DRI_Background denotes Part of the bronchial epithelia were exfoliated.
T17 1769-1893 DRI_Background denotes Coronavirus particles in bronchial mucosal epithelia and type II alveolar epithelia were observed under electron microscope.
T18 1894-2018 DRI_Outcome denotes Immunohistochemical staining showed that part of the alveolar epithelia and macrophages were positive for 2019-nCoV antigen.
T19 2019-2097 DRI_Background denotes Real time PCR analyses identified positive signals for 2019-nCoV nucleic acid.
T20 2098-2186 DRI_Background denotes Decreased numbers of lymphocyte, cell degeneration and necrosis were observed in spleen.
T21 2187-2456 DRI_Background denotes Furthermore, degeneration and necrosis of parenchymal cells, formation of hyaline thrombus in small vessels, and pathological changes of chronic diseases were observed in other organs and tissues, while no evidence of coronavirus infection was observed in these organs.
T22 2457-2708 DRI_Challenge denotes Conclusion: s The lungs from novel coronavirus pneumonia patients manifest significant pathological lesions, including the alveolar exudative inflammation and interstitial inflammation, alveolar epithelium proliferation and hyaline membrane formation.
T23 2709-2853 DRI_Background denotes While the 2019-nCoV is mainly distributed in lung, the infection also involves in the damages of heart, vessels, liver, kidney and other organs.
T24 2854-2961 DRI_Challenge denotes Further studies are warranted to investigate the mechanism underlying pathological changes of this disease.