| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-158 |
DRI_Background |
denotes |
An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV2). |
| T2 |
159-379 |
DRI_Background |
denotes |
The city of Wuhan, Hubei province, China, was the origin of a severe pneumonia outbreak in December 2019, attributed to a novel coronavirus (SARS-CoV2), causing a total of 2761 deaths and 81109 cases (February 25, 2020). |
| T3 |
447-548 |
DRI_Background |
denotes |
The polyprotein 1ab (pp1ab) remains unstudied thoroughly since it is similar to other sarbecoviruses. |
| T4 |
549-663 |
DRI_Approach |
denotes |
In this short communication, we performed phylogenetic-structural sequence analysis of pp1ab protein of SARS-CoV2. |
| T5 |
664-947 |
DRI_Outcome |
denotes |
The analysis showed that the viral pp1ab has not changed in most isolates throughout the outbreak time, but interestingly a deletion of 8 aa in the virulence factor non-structural protein 1 was found in a virus isolated from a Japanese patient that did not display critical symptoms. |
| T6 |
948-1088 |
DRI_Approach |
denotes |
While comparing pp1ab protein with other betacoronaviruses, we found a 42 amino acid signature that is only present in SARS-CoV2 (AS-SCoV2). |
| T7 |
1089-1158 |
DRI_Background |
denotes |
Members from clade 2 of sarbecoviruses have traces of this signature. |
| T8 |
1159-1365 |
DRI_Background |
denotes |
The AS-SCoV2 located in the acidic-domain of papain-like protein of SARS-CoV2 and bat-SL-RatG13 guided us to suggest that the novel 2019 coronavirus probably emerged by genetic drift from bat-SL-CoV-RaTG13. |
| T9 |
1366-1503 |
DRI_Approach |
denotes |
The implication of this amino acid signature in papain-like protein structure arrangement and function is something worth to be explored. |
