| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
97-212 |
DRI_Challenge |
denotes |
A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. |
| T2 |
213-359 |
DRI_Approach |
denotes |
This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. |
| T3 |
360-515 |
DRI_Background |
denotes |
It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). |
| T4 |
516-630 |
DRI_Approach |
denotes |
The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. |
| T5 |
631-783 |
DRI_Approach |
denotes |
We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy. |
