LitCovid-ArguminSci  

PubMed:32077659 JSONTXT 37 Projects

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Id Subject Object Predicate Lexical cue
T1 0-110 DRI_Challenge denotes [Exploring the mechanism of liver enzyme abnormalities in patients with novel coronavirus-infected pneumonia].
T2 111-261 DRI_Background denotes Objective: To explore and analyze the possible mechanism of liver injury in patients with coronavirus disease 2019 (novel coronavirus pneumonia, NCP).
T3 262-434 DRI_Background denotes Methods: The correlation between ALT, AST and other liver enzyme changes condition and NCP patients' disease status reported in the literature was comprehensively analyzed.
T4 435-551 DRI_Background denotes ACE2 expression in liver tissue for novel coronavirus was analyzed based on single cell sequencing (GSE115469) data.
T5 552-775 DRI_Background denotes RNA-Seq method was used to analyze Ace2 expression and transcription factors related to its expression in liver tissues at various time-points after hepatectomy in mouse model of acute liver injury with partial hepatectomy.
T6 776-855 DRI_Background denotes t-test or Spearman rank correlation analysis was used for statistical analysis.
T7 856-1071 DRI_Background denotes Results: ALT and AST were abnormally elevated in some patients with novel coronavirus infection, and the rate and extent of ALT and AST elevation in severe NCP patients were higher than those in non-severe patients.
T8 1072-1263 DRI_Background denotes Liver tissue results of single cell sequencing and immunohistochemistry showed that ACE2 was only expressed in bile duct epithelial cells of normal liver tissues, and very low in hepatocytes.
T9 1264-1558 DRI_Outcome denotes In a mouse model of acute liver injury with partial hepatectomy, Ace2 expression was down-regulated on the first day, but it was elevated up to twice of the normal level on the third day, and returned to normal level on seventh day when the liver recovered and hepatocyte proliferation stopped.
T10 1559-1759 DRI_Challenge denotes Whether this phenomenon suggests that the bile duct epithelial cells with positive expression of Ace2 participate in the process of liver regeneration after partial hepatectomy deserves further study.
T11 1760-2011 DRI_Approach denotes In RNA-Seq data, 77 transcription factors were positively correlated with the expression of ACE2 (r > 0.2, FDR < 0.05), which were mainly enriched in the development, differentiation, morphogenesis and cell proliferation of glandular epithelial cells.
T12 2012-2364 DRI_Challenge denotes Conclusion: We assumed that in addition to the over activated inflammatory response in patients with NCP, the up-regulation of ACE2 expression in liver tissue caused by compensatory proliferation of hepatocytes derived from bile duct epithelial cells may also be the possible mechanism of liver tissue injury caused by 2019 novel coronavirus infection.