| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-113 |
Sentence |
denotes |
Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells. |
| T2 |
114-347 |
Sentence |
denotes |
Myotonic dystrophy (DM), the most prevalent muscular disorder in adults, is caused by (CTG)n-repeat expansion in a gene encoding a protein kinase (DM protein kinase; DMPK) and involves changes in cytoarchitecture and ion homeostasis. |
| T3 |
348-651 |
Sentence |
denotes |
To obtain clues to the normal biological role of DMPK in cellular ion homeostasis, we have compared the resting [Ca2+]i, the amplitude and shape of depolarization-induced Ca2+ transients, and the content of ATP-driven ion pumps in cultured skeletal muscle cells of wild-type and DMPK[-/-] knockout mice. |
| T4 |
652-844 |
Sentence |
denotes |
In vitro-differentiated DMPK[-/-] myotubes exhibit a higher resting [Ca2+]i than do wild-type myotubes because of an altered open probability of voltage-dependent l-type Ca2+ and Na+ channels. |
| T5 |
845-960 |
Sentence |
denotes |
The mutant myotubes exhibit smaller and slower Ca2+ responses upon triggering by acetylcholine or high external K+. |
| T6 |
961-1099 |
Sentence |
denotes |
In addition, we observed that these Ca2+ transients partially result from an influx of extracellular Ca2+ through the l-type Ca2+ channel. |
| T7 |
1100-1222 |
Sentence |
denotes |
Neither the content nor the activity of Na+/K+ ATPase and sarcoplasmic reticulum Ca2+-ATPase are affected by DMPK absence. |
| T8 |
1223-1364 |
Sentence |
denotes |
In conclusion, our data suggest that DMPK is involved in modulating the initial events of excitation-contraction coupling in skeletal muscle. |
