LitCoin-sentences  

PubMed:30836660 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways.
T2 110-281 Sentence denotes Salidroside (Sal) is an active ingredient that is isolated from Rhodiola rosea, which has been reported to have anti-inflammatory activities and a renal protective effect.
T3 282-353 Sentence denotes However, the role of Sal on renal fibrosis has not yet been elucidated.
T4 354-557 Sentence denotes Here, the purpose of the current study is to test the protective effects of Sal against renal interstitial fibrosis (RIF), and to explore the underlying mechanisms using both in vivo and in vitro models.
T5 558-812 Sentence denotes In this study, we establish the unilateral ureteric obstruction (UUO) or folic acid (FA)-induced mice renal interstitial fibrosis in vivo and the transforming growth factor (TGF)-β1-stimulated human proximal tubular epithelial cell (HK-2) model in vitro.
T6 813-905 Sentence denotes The levels of kidney functional parameters and inflammatory cytokines in serum are examined.
T7 906-987 Sentence denotes The degree of renal damage and fibrosis is determined by histological assessment.
T8 988-1086 Sentence denotes Immunohistochemistry and western blotting are used to determine the mechanisms of Sal against RIF.
T9 1087-1256 Sentence denotes Our results show that treatment with Sal can ameliorate tubular injury and deposition of the extracellular matrix (ECM) components (including collagen Ш and collagen I).
T10 1257-1483 Sentence denotes Furthermore, Sal administration significantly suppresses epithelial-mesenchymal transition (EMT), as evidenced by a decreased expression of α-SMA, vimentin, TGF-β1, snail, slug, and a largely restored expression of E-cadherin.
T11 1484-1697 Sentence denotes Additionally, Sal also reduces the levels of serum biochemical markers (serum creatinine, Scr; blood urea nitrogen, BUN; and uric acid, UA) and decreases the release of inflammatory cytokines (IL-1β, IL-6, TNF-α).
T12 1698-1912 Sentence denotes Further study revealed that the effect of Sal on renal interstitial fibrosis is associated with the lower expression of TLR4, p-IκBα, p-NF-κB and mitogen-activated protein kinases (MAPK), both in vivo and in vitro.
T13 1913-2096 Sentence denotes In conclusion, Sal treatment improves kidney function, ameliorates the deposition of the ECM components and relieves the protein levels of EMT markers in mouse kidneys and HK-2 cells.
T14 2097-2242 Sentence denotes Furthermore, Sal treatment significantly decreases the release of inflammatory cytokines and inhibits the TLR4/NF-κB and MAPK signaling pathways.
T15 2243-2375 Sentence denotes Collectively, these results suggest that the administration of Sal could be a novel therapeutic strategy in treating renal fibrosis.