LitCoin-sentences  

PubMed:29183288 JSONTXT 40 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.
T2 131-241 Sentence denotes BACKGROUND: (Over-)expression of arginase may limit local availability of arginine for nitric oxide synthesis.
T3 242-433 Sentence denotes We investigated the significance of arginase1 (ARG1) for the development of airway hyperresponsiveness (AHR) and lung inflammation in female mice with ovalbumin (OVA)-induced allergic asthma.
T4 434-442 Sentence denotes METHODS:
T5 443-517 Sentence denotes Arg1 was ablated in the lung by crossing Arg1 fl/fl and Tie2Cre tg/- mice.
T6 518-632 Sentence denotes OVA sensitization and challenge were conducted, and AHR to methacholine was determined using the Flexivent system.
T7 633-803 Sentence denotes Changes in gene expression, chemokine and cytokine secretion, plasma IgE, and lung histology were quantified using RT-qPCR, ELISA, and immunohistochemistry, respectively.
T8 804-812 Sentence denotes RESULTS:
T9 813-1160 Sentence denotes Arg1 ablation had no influence on the development of OVA-induced AHR, but attenuated OVA-induced increases in expression of Arg2 and Nos2, Slc7a1, Slc7a2, and Slc7a7 (arginine transporters), Il4, Il5 and Il13 (TH2-type cytokines), Ccl2 and Ccl11 (chemokines), Ifng (TH1-type cytokine), Clca3 and Muc5ac (goblet cell markers), and OVA-specific IgE.
T10 1161-1293 Sentence denotes Pulmonary IL-10 protein content increased, but IL-4, IL-5, IL-13, TNFα and IFNγ content, and lung histopathology, were not affected.
T11 1294-1464 Sentence denotes Arg1 elimination also decreased number and tightness of correlations between adaptive changes in lung function and inflammatory parameters in OVA/OVA-treated female mice.
T12 1465-1608 Sentence denotes OVA/OVA-treated female mice mounted a higher OVA-IgE response than males, but the correlation between lung function and inflammation was lower.
T13 1609-1862 Sentence denotes Arg1-deficient OVA/OVA-treated females differed from males in a more pronounced decline of arginine-metabolizing and -transporting genes, higher plasma arginine levels, a smaller OVA-specific IgE response, and no improvement of peripheral lung function.
T14 1863-1874 Sentence denotes CONCLUSION:
T15 1875-2088 Sentence denotes Complete ablation of Arg1 in the lung affects mRNA abundance of arginine-transporting and -metabolizing genes, and pro-inflammatory genes, but not methacholine responsiveness or accumulation of inflammatory cells.