LitCoin-sentences  

PubMed:28660748 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes Angiotensin II subtype 1a receptor signaling in resident hepatic macrophages induces liver metastasis formation.
T2 113-196 Sentence denotes Liver metastases from colorectal cancer (CRC) are a clinically significant problem.
T3 197-269 Sentence denotes The renin-angiotensin system is involved in tumor growth and metastases.
T4 270-404 Sentence denotes This study was designed to evaluate the role of angiotensin II subtype receptor 1a (AT1a) in the formation of liver metastasis in CRC.
T5 405-571 Sentence denotes A model of liver metastasis was developed by intrasplenic injection of mouse colon cancer (CMT-93) into AT1a knockout mice (AT1aKO) and wild-type (C57BL/6) mice (WT).
T6 572-673 Sentence denotes Compared with WT mice, the liver weight and liver metastatic rate were significantly lower in AT1aKO.
T7 674-793 Sentence denotes The mRNA levels of CD31, transforming growth factor- β1 (TGF-β1), and F4/80 were suppressed in AT1aKO compared with WT.
T8 794-952 Sentence denotes Double immunofluorescence analysis showed that the number of accumulated F4/80(+) cells expressing TGF-β1 in metastatic areas was higher in WT than in AT1aKO.
T9 953-1067 Sentence denotes The AT1aKO bone marrow (BM) (AT1aKO-BM)→WT showed suppressed formation of liver metastasis compared with WT-BM→WT.
T10 1068-1171 Sentence denotes However, the formation of metastasis was further suppressed in WT-BM→AT1aKO compared with AT1aKO-BM→WT.
T11 1172-1383 Sentence denotes In addition, accumulated F4/80(+) cells in the liver metastasis were not BM-derived F4/80(+) cells, but mainly resident hepatic F4/80(+) cells, and these resident hepatic F4/80(+) cells were positive for TGF-β1.
T12 1384-1443 Sentence denotes Angiotensin II enhanced TGF-β1 expression in Kupffer cells.
T13 1444-1567 Sentence denotes Treatment of WT with clodronate liposomes suppressed liver metastasis by diminishing TGF-β1(+) F4/80(+) cells accumulation.
T14 1568-1700 Sentence denotes The formation of liver metastasis correlated with collagen deposition in the metastatic area, which was dependent on AT1a signaling.
T15 1701-1840 Sentence denotes These results suggested that resident hepatic macrophages induced liver metastasis formation by induction of TGF-β1 through AT1a signaling.