| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-121 |
Sentence |
denotes |
Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis. |
| T2 |
122-270 |
Sentence |
denotes |
The endosomal sorting complex required for transport (ESCRT)-III mediates membrane fission in fundamental cellular processes, including cytokinesis. |
| T3 |
271-384 |
Sentence |
denotes |
ESCRT-III is thought to form persistent filaments that over time increase their curvature to constrict membranes. |
| T4 |
385-546 |
Sentence |
denotes |
Unexpectedly, we found that ESCRT-III at the midbody of human cells rapidly turns over subunits with cytoplasmic pools while gradually forming larger assemblies. |
| T5 |
547-733 |
Sentence |
denotes |
ESCRT-III turnover depended on the ATPase VPS4, which accumulated at the midbody simultaneously with ESCRT-III subunits, and was required for assembly of functional ESCRT-III structures. |
| T6 |
734-932 |
Sentence |
denotes |
In vitro, the Vps2/Vps24 subunits of ESCRT-III formed side-by-side filaments with Snf7 and inhibited further polymerization, but the growth inhibition was alleviated by the addition of Vps4 and ATP. |
| T7 |
933-1074 |
Sentence |
denotes |
High-speed atomic force microscopy further revealed highly dynamic arrays of growing and shrinking ESCRT-III spirals in the presence of Vps4. |
| T8 |
1075-1249 |
Sentence |
denotes |
Continuous ESCRT-III remodelling by subunit turnover might facilitate shape adaptions to variable membrane geometries, with broad implications for diverse cellular processes. |
