LitCoin-sentences  

PubMed:28428256 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Regulation of lung endothelial permeability and inflammatory responses by prostaglandin A2: role of EP4 receptor.
T2 114-208 Sentence denotes The role of prostaglandin A2 (PGA2) in modulation of vascular endothelial function is unknown.
T3 209-367 Sentence denotes We investigated effects of PGA2 on pulmonary endothelial cell (EC) permeability and inflammatory activation and identified a receptor mediating these effects.
T4 368-537 Sentence denotes PGA2 enhanced the EC barrier and protected against barrier dysfunction caused by vasoactive peptide thrombin and proinflammatory bacterial wall lipopolysaccharide (LPS).
T5 538-655 Sentence denotes Receptor screening using pharmacological and molecular inhibitory approaches identified EP4 as a novel PGA2 receptor.
T6 656-853 Sentence denotes EP4 mediated barrier-protective effects of PGA2 by activating Rap1/Rac1 GTPase and protein kinase A targets at cell adhesions and cytoskeleton: VE-cadherin, p120-catenin, ZO-1, cortactin, and VASP.
T7 854-997 Sentence denotes PGA2 also suppressed LPS-induced inflammatory signaling by inhibiting the NFκB pathway and expression of EC adhesion molecules ICAM1 and VCAM1.
T8 998-1077 Sentence denotes These effects were abolished by pharmacological or molecular inhibition of EP4.
T9 1078-1304 Sentence denotes In vivo, PGA2 was protective in two distinct models of acute lung injury (ALI): LPS-induced inflammatory injury and two-hit ALI caused by suboptimal mechanical ventilation and injection of thrombin receptor-activating peptide.
T10 1305-1392 Sentence denotes These protective effects were abolished in mice with endothelial-specific EP4 knockout.
T11 1393-1590 Sentence denotes The results suggest a novel role for the PGA2-EP4 axis in vascular EC protection that is critical for improvement of pathological states associated with increased vascular leakage and inflammation.