LitCoin-sentences  

PubMed:28393239 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Psoriasin promotes invasion, aggregation and survival of pancreatic cancer cells; association with disease progression.
T2 120-229 Sentence denotes Psoriasin (S100A7) is an 11-kDa small calcium binding protein initially isolated from psoriatic skin lesions.
T3 230-396 Sentence denotes It belongs to the S100 family of proteins which play an important role in a range of cell functions including proliferation, differentiation, migration and apoptosis.
T4 397-513 Sentence denotes Aberrant Psoriasin expression has been implicated in a range of cancers and is often associated with poor prognosis.
T5 514-642 Sentence denotes This study examined the role of Psoriasin on pancreatic cancer cell functions and the implication in progression of the disease.
T6 643-799 Sentence denotes Expression of Psoriasin was determined in a cohort of pancreatic tissues comprised of 126 pancreatic tumours and 114 adjacent non-tumour pancreatic tissues.
T7 800-1026 Sentence denotes Knockdown and overexpression of Psoriasin in pancreatic cancer cells was performed using specifically constructed plasmids, which either had anti-Psoriasin ribozyme transgene or the full length human Psoriasin coding sequence.
T8 1027-1114 Sentence denotes Psoriasin knockdown and overexpression was verified using conventional RT-PCR and qPCR.
T9 1115-1256 Sentence denotes The effect of manipulating Psoriasin expression on pancreatic cancer cell functions was assessed using several in vitro cell function assays.
T10 1257-1420 Sentence denotes Local invasive pancreatic cancers extended beyond the pancreas expressed higher levels of Psoriasin transcripts compared with the cancers confined to the pancreas.
T11 1421-1505 Sentence denotes Primary tumours with distant metastases exhibited a reduced expression of Psoriasin.
T12 1506-1623 Sentence denotes Psoriasin overexpression cell lines exhibited significantly increased growth and migration compared to control cells.
T13 1624-1803 Sentence denotes In addition, Psoriasin overexpression resulted in increased pancreatic cancer cell invasion which was associated with upregulation of matrix metalloproteinase-2 (MMP-2) and MMP-9.
T14 1804-1923 Sentence denotes Overexpression of Psoriasin also promoted aggregation and survival of pancreatic cancer cells when they lost anchorage.
T15 1924-2028 Sentence denotes Taken together, higher expression of Psoriasin was associated with local invasion in pancreatic cancers.
T16 2029-2169 Sentence denotes Psoriasin expression is associated with pancreatic cancer cell growth, migration, cell-matrix adhesion, and invasion via regulation of MMPs.
T17 2170-2319 Sentence denotes As such, the proposed implications of Psoriasin in invasion, disease progression and as a potential therapeutic target warrant further investigation.