LitCoin-sentences  

PubMed:28346429 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes Deletion of endothelial cell-specific liver kinase B1 increases angiogenesis and tumor growth via vascular endothelial growth factor.
T2 134-236 Sentence denotes Liver kinase B1 (LKB1) is a serine/threonine protein kinase ubiquitously expressed in mammalian cells.
T3 237-314 Sentence denotes It was first identified in Peutz-Jeghers syndrome as a tumor suppressor gene.
T4 315-391 Sentence denotes Whether endothelial LKB1 regulates angiogenesis and tumor growth is unknown.
T5 392-563 Sentence denotes In this study, we generated endothelial cell-specific LKB1-knockout (LKB1(endo-/-)) mice by crossbreeding vascular endothelial-cadherin-Cre mice with LKB1(flox/flox) mice.
T6 564-700 Sentence denotes Vascular endothelial growth factor (VEGF) level was highly co-stained in endothelial cells but not in macrophages in LKB1(endo-/-) mice.
T7 701-825 Sentence denotes Consistently, LKB1(endo-/-) mouse tissues including the lung, skin, kidney and liver showed increased vascular permeability.
T8 826-1044 Sentence denotes Tumors implanted in LKB1(endo-/-) mice but not macrophage-specific LKB1-knockout mice grew faster and showed enhanced vascular permeability and increased angiogenesis as compared with those implanted in wild-type mice.
T9 1045-1195 Sentence denotes Injection of VEGF-neutralizing antibody but not the isotype-matched control antibody decreased endothelial-cell angiogenesis and tumor growth in vivo.
T10 1196-1371 Sentence denotes Furthermore, LKB1 deletion enhanced mouse retinal and cell angiogenesis, and knockdown of VEGF by small-interfering RNA decreased endothelial cell proliferation and migration.
T11 1372-1505 Sentence denotes Re-expression of LKB1 or knockdown of VEGF receptor 2 decreased the overproliferation and -migration observed in LKB1(endo-/-) cells.
T12 1506-1689 Sentence denotes Mechanistically, LKB1 could bind to the VEGF transcription factor, specificity protein 1 (Sp1), which then inhibited the binding of Sp1 to the VEGF promoter to reduce VEGF expression.
T13 1690-1805 Sentence denotes Endothelial LKB1 may regulate endothelial angiogenesis and tumor growth by modulating Sp1-mediated VEGF expression.