LitCoin-sentences  

PubMed:28260077 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Atorvastatin protects against contrast-induced nephropathy via anti-apoptosis by the upregulation of Hsp27 in vivo and in vitro.
T2 129-291 Sentence denotes Contrast-induced nephropathy (CIN) is an iatrogenic acute renal failure occurring following the intravascular injection of iodinated radiographic contrast medium.
T3 292-365 Sentence denotes However, the regulatory mechanisms for CIN remain to be fully elucidated.
T4 366-524 Sentence denotes The present study aimed to investigate whether atorvastatin protects against CIN via anti‑apoptotic effects by the upregulation of Hsp27 in vivo and in vitro.
T5 525-751 Sentence denotes To determine whether atorvastatin attenuated CIN, the inflammatory response and apoptosis in vivo and in vitro, a rat model of iopamidol‑induced CIN was used, and human embryonic proximal tubule (HK2) cell damage was assessed.
T6 752-821 Sentence denotes The rats were assigned into four groups (n=10 per group), as follows:
T7 822-901 Sentence denotes Control rats; rats+atorvastatin; rats + iopamidol; rats+iopamidol+atorvastatin.
T8 902-1069 Sentence denotes In vitro, the HK2 cells were treated with iopamidol in the presence or absence of atorvastatin, heat shock protein (Hsp)27 small interfering (si)RNA or pcDNA3.1‑Hsp27.
T9 1070-1162 Sentence denotes The renal tissues were examined histopathologically and collected for western blot analysis.
T10 1163-1271 Sentence denotes The results showed that atorvastatin ameliorated the apoptosis and deterioration of renal function (P<0.05).
T11 1272-1462 Sentence denotes Furthermore, atorvastatin reduced the iopamidol‑induced activity of B cell lymphoma‑2 (Bcl‑2)‑associated X protein (Bax)/caspase‑3 and increased the expression of Bcl‑2 in vivo and in vitro.
T12 1463-1670 Sentence denotes Notably, following treatment with Hsp27 siRNA or pcDNA3.1‑Hsp27, it was found that iopamidol enhanced or weakened the upregulation of Bax/caspase‑3 and downregulation of Bcl‑2 in the HK2 cells, respectively.
T13 1671-1851 Sentence denotes The results of the present study suggested that atorvastatin protected against contrast‑induced renal tubular cell apoptosis through the upregulation of Hsp27 in vivo and in vitro.