| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-97 |
Sentence |
denotes |
CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes. |
| T2 |
98-236 |
Sentence |
denotes |
Meiotic resumption (G2/M transition) and progression through meiosis I (MI) are two key stages for producing fertilization-competent eggs. |
| T3 |
237-369 |
Sentence |
denotes |
Here, we report that CenpH, a component of the kinetochore inner plate, is responsible for G2/M transition in meiotic mouse oocytes. |
| T4 |
370-559 |
Sentence |
denotes |
Depletion of CenpH by morpholino injection decreased cyclin B1 levels, resulting in attenuation of maturation-promoting factor (MPF) activation, and severely compromised meiotic resumption. |
| T5 |
560-747 |
Sentence |
denotes |
CenpH protects cyclin B1 from destruction by competing with the action of APC/C(Cdh1) Impaired G2/M transition after CenpH depletion could be rescued by expression of exogenous cyclin B1. |
| T6 |
748-881 |
Sentence |
denotes |
Unexpectedly, blocking CenpH did not affect spindle organization and meiotic cell cycle progression after germinal vesicle breakdown. |
| T7 |
882-1010 |
Sentence |
denotes |
Our findings reveal a novel role of CenpH in regulating meiotic G2/M transition by acting via the APC/C(Cdh1)-cyclin B1 pathway. |
