LitCoin-sentences  

PubMed:27941998 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy.
T2 118-233 Sentence denotes Desminopathies caused by the mutation in the gene coding for desmin are genetically protein aggregation myopathies.
T3 234-335 Sentence denotes Mitochondrial dysfunction is one of pathological changes in the desminopathies at the earliest stage.
T4 336-424 Sentence denotes The molecular mechanisms of mitochondria dysfunction in desminopathies remain exclusive.
T5 425-545 Sentence denotes VDAC1 regulates mitochondrial uptake across the outer membrane and mitochondrial outer membrane permeabilization (MOMP).
T6 546-644 Sentence denotes Relationships between desminopathies and Voltage-dependent anion channel 1 (VDAC1) remain unclear.
T7 645-874 Sentence denotes Here we successfully constructed the desminopathy rat model, evaluated with conventional stains, containing hematoxylin and eosin (HE), Gomori Trichrome (MGT), (PAS), red oil (ORO), NADH-TR, SDH staining and immunohistochemistry.
T8 875-1066 Sentence denotes Immunofluorescence results showed that VDAC1 was accumulated in the desmin highly stained area of muscle fibers of desminopathy patients or desminopathy rat model compared to the normal ones.
T9 1067-1343 Sentence denotes Meanwhile apoptosis related proteins bax and ATF2 were involved in desminopathy patients and desminopathy rat model, but not bcl-2, bcl-xl or HK2.VDAC1 and desmin are closely relevant in the tissue splices of deminopathies patients and rats with desminopathy at protein lever.
T10 1344-1459 Sentence denotes Moreover, apoptotic proteins are also involved in the desminopathies, like bax, ATF2, but not bcl-2, bcl-xl or HK2.
T11 1460-1604 Sentence denotes This pathological analysis presents the correlation between VDAC1 and desmin, and apoptosis related proteins are correlated in the desminopathy.
T12 1605-1706 Sentence denotes Furthermore, we provide a rat model of desminopathy for the investigation of desmin related myopathy.