LitCoin-sentences  

PubMed:27729412 JSONTXT 26 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-168 Sentence denotes Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue.
T2 169-289 Sentence denotes Adiponectin is an adipocyte-derived adipokine with potent antidiabetic, anti-inflammatory, and antiatherogenic activity.
T3 290-444 Sentence denotes Long-term, high-fat diet results in gain of body weight, adiposity, further inflammatory-based cardiovascular diseases, and reduced adiponectin secretion.
T4 445-575 Sentence denotes Vitamin A derivatives/retinoids are involved in several of these processes, which mainly take place in white adipose tissue (WAT).
T5 576-698 Sentence denotes In this study, we examined adiponectin expression as a function of dietary high-fat and high-vitamin A conditions in mice.
T6 699-951 Sentence denotes A decrease of adiponectin expression in addition to an up-regulation of aldehyde dehydrogenase A1 (ALDH1A1), retinoid signaling, and retinoic acid response element signaling was selectively observed in WAT of mice fed a normal-vitamin A, high-fat diet.
T7 952-1042 Sentence denotes Reduced adiponectin expression in WAT was also observed in mice fed a high-vitamin A diet.
T8 1043-1321 Sentence denotes Adipocyte cell culture revealed that endogenous and synthetic retinoic acid receptor (RAR)α- and RARγ-selective agonists, as well as a synthetic retinoid X receptor agonist, efficiently reduced adiponectin expression, whereas ALDH1A1 expression only increased with RAR agonists.
T9 1322-1830 Sentence denotes We conclude that reduced adiponectin expression under high-fat dietary conditions is dependent on 1) increased ALDH1A1 expression in adipocytes, which does not increase all-trans-retinoic acid levels; 2) further RAR ligand-induced, WAT-selective, increased retinoic acid response element-mediated signaling; and 3) RAR ligand-dependent reduction of adiponectin expression.-Landrier, J.-F., Kasiri, E., Karkeni, E., Mihály, J., Béke, G., Weiss, K., Lucas, R., Aydemir, G., Salles, J., Walrand, S., de Lera, A.
T10 1831-1843 Sentence denotes R., Rühl, R.
T11 1844-2012 Sentence denotes Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue.