| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-143 |
Sentence |
denotes |
Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth. |
| T2 |
144-258 |
Sentence |
denotes |
Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. |
| T3 |
259-327 |
Sentence |
denotes |
Despite this correlation, CIN can also lead to growth disadvantages. |
| T4 |
328-542 |
Sentence |
denotes |
Here, we show that simultaneous overexpression of the mitotic checkpoint protein Mad2 with Kras(G12D) or Her2 in mammary glands of adult mice results in mitotic checkpoint overactivation and a delay in tumor onset. |
| T5 |
543-699 |
Sentence |
denotes |
Time-lapse imaging of organotypic cultures and pathologic analysis prior to tumor establishment reveals error-prone mitosis, mitotic arrest, and cell death. |
| T6 |
700-788 |
Sentence |
denotes |
Nonetheless, Mad2 expression persists and increases karyotype complexity in Kras tumors. |
| T7 |
789-969 |
Sentence |
denotes |
Faced with the selective pressure of oncogene withdrawal, Mad2-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow. |
