LitCoin-sentences  

PubMed:27103577 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.
T2 117-267 Sentence denotes The role of peroxisome proliferator-activated receptor α (PPARα)-mediated metabolic remodeling in cardiac adaptation to hypoxia has yet to be defined.
T3 268-375 Sentence denotes Here, mice were housed in hypoxia for 3 wk before in vivo contractile function was measured using cine MRI.
T4 376-558 Sentence denotes In isolated, perfused hearts, energetics were measured using (31)P magnetic resonance spectroscopy (MRS), and glycolysis and fatty acid oxidation were measured using [(3)H] labeling.
T5 559-854 Sentence denotes Compared with a normoxic, chow-fed control mouse heart, hypoxia decreased PPARα expression, fatty acid oxidation, and mitochondrial uncoupling protein 3 (UCP3) levels, while increasing glycolysis, all of which served to maintain normal ATP concentrations ([ATP]) and thereby, ejection fractions.
T6 855-971 Sentence denotes A high-fat diet increased cardiac PPARα expression, fatty acid oxidation, and UCP3 levels with decreased glycolysis.
T7 972-1164 Sentence denotes Hypoxia was unable to alter the high PPARα expression or reverse the metabolic changes caused by the high-fat diet, with the result that [ATP] and contractile function decreased significantly.
T8 1165-1407 Sentence denotes The adaptive metabolic changes caused by hypoxia in control mouse hearts were found to have occurred already in PPARα-deficient (PPARα(-/-)) mouse hearts and sustained function in hypoxia despite an inability for further metabolic remodeling.
T9 1408-1560 Sentence denotes We conclude that decreased cardiac PPARα expression is essential for adaptive metabolic remodeling in hypoxia, but is prevented by dietary fat.-Cole, M.
T10 1561-1578 Sentence denotes A., Abd Jamil, A.
T11 1579-1594 Sentence denotes H., Heather, L.
T12 1595-1609 Sentence denotes C., Murray, A.
T13 1610-1624 Sentence denotes J., Sutton, E.
T14 1625-1670 Sentence denotes R., Slingo, M., Sebag-Montefiore, L., Tan, S.
T15 1671-1703 Sentence denotes C., Aksentijević, D., Gildea, O.
T16 1704-1719 Sentence denotes S., Stuckey, D.
T17 1720-1732 Sentence denotes J., Yeoh, K.
T18 1733-1745 Sentence denotes K., Carr, C.
T19 1746-1759 Sentence denotes A., Evans, R.
T20 1760-1788 Sentence denotes D., Aasum, E., Schofield, C.
T21 1789-1806 Sentence denotes J., Ratcliffe, P.
T22 1807-1836 Sentence denotes J., Neubauer, S., Robbins, P.
T23 1837-1851 Sentence denotes A., Clarke, K.
T24 1852-1968 Sentence denotes On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.