LitCoin-sentences  

PubMed:26900322 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes CFI-rs7356506 polymorphisms associated with Vogt-Koyanagi-Harada syndrome.
T2 75-83 Sentence denotes PURPOSE:
T3 84-218 Sentence denotes Complement factor I (CFI) plays an important role in complement activation pathways and is known to affect the development of uveitis.
T4 219-372 Sentence denotes The present study was performed to investigate the existence of an association between CFI genetic polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome.
T5 373-381 Sentence denotes METHODS:
T6 382-488 Sentence denotes A total of 100 patients diagnosed with VKH syndrome and 300 healthy controls were recruited for the study.
T7 489-574 Sentence denotes Two milliliters of peripheral blood were collected in a sterile anticoagulative tube.
T8 575-654 Sentence denotes CFI-rs7356506 polymorphisms were genotyped using Sequenom MassARRAY technology.
T9 655-749 Sentence denotes Allele and genotype frequencies were compared between patients and controls using a χ(2) test.
T10 750-859 Sentence denotes The analyses were stratified for recurrent status, complicated cataract status, and steroid-sensitive status.
T11 860-868 Sentence denotes RESULTS:
T12 869-959 Sentence denotes No significant association was found between CFI-rs7356506 polymorphisms and VKH syndrome.
T13 960-1239 Sentence denotes However, patients with recurrent VKH syndrome had lower frequencies of the G allele and GG homozygosity in CFI-rs7356506 when compared to the controls (p=0.016, odds ratio [OR]=0.429, 95% confidence interval [CI]=0.212-0.871; p=0.014, OR=0.364, 95% CI=0.158-0.837, respectively).
T14 1240-1532 Sentence denotes Furthermore, there were significant decreases in the frequencies of the G allele and GG homozygosity in CFI-rs7356506 in patients with VKH syndrome with complicated cataract compared to the controls (p<0.001, OR=0.357, 95% CI=0.197-0.648; p<0.001, OR=0.273, 95% CI=0.135-0.551, respectively).
T15 1533-1681 Sentence denotes Nevertheless, no significant association with patients with VKH syndrome in steroid-sensitive statuses was detected for CFI-rs7356506 polymorphisms.
T16 1682-1694 Sentence denotes CONCLUSIONS:
T17 1695-1993 Sentence denotes Our results indicate that CFI polymorphisms are not significantly associated with VKH syndrome; nevertheless, we identified a trend for the association of CFI-7356506 with VKH syndrome that depends on the recurrent status and the complicated cataract status but not on the steroid-sensitive status.