| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-131 |
Sentence |
denotes |
Upregulation of centrosomal protein 55 is associated with unfavorable prognosis and tumor invasion in epithelial ovarian carcinoma. |
| T2 |
132-234 |
Sentence |
denotes |
Centrosomal protein 55 (CEP55) is a cell cycle regulator implicated in development of certain cancers. |
| T3 |
235-377 |
Sentence |
denotes |
However, characteristics of CEP55 expression and its clinical/prognostic significance are unclear in human epithelial ovarian carcinoma (EOC). |
| T4 |
378-560 |
Sentence |
denotes |
Therefore, we investigated the expression and clinicopathological significance of CEP55 in patients with EOC and its role in regulating invasion and metastasis of ovarian cell lines. |
| T5 |
561-706 |
Sentence |
denotes |
CEP55 mRNA and protein expression levels were detected by quantitative real-time PCR (qRT-PCR), Western blotting, and immunohistochemistry (IHC). |
| T6 |
707-818 |
Sentence |
denotes |
Potential associations of CEP55 expression scores with clinical parameters and patient survival were evaluated. |
| T7 |
819-980 |
Sentence |
denotes |
CEP55 function was investigated further using RNA interference, wound healing assay, transwell assay, immunofluorescence analysis, qRT-PCR, and Western blotting. |
| T8 |
981-1127 |
Sentence |
denotes |
CEP55 was significantly upregulated in ovarian cancer cell lines and lesions compared with normal cells and adjacent noncancerous ovarian tissues. |
| T9 |
1128-1477 |
Sentence |
denotes |
In the 213 EOC samples, CEP55 protein levels were positively correlated with clinical stage (P < 0.001), lymph node metastasis (P < 0.001), intraperitoneal metastasis (P < 0.001), tumor recurrence (P < 0.001), differentiation grade (P < 0.001), residual tumor size (P < 0.001), ascites see tumor cells (P = 0.020), and serum CA153 level (P < 0.001). |
| T10 |
1478-1640 |
Sentence |
denotes |
Moreover, patients with aberrant CEP55 protein expression showed tendencies to receive neoadjuvant chemotherapy (P < 0.001) and cytoreductive surgery (P = 0.020). |
| T11 |
1641-1814 |
Sentence |
denotes |
By contrast, no significant correlation was detected between the protein levels and patient age, histological type, or serum CA125, CA199, CA724, NSE, CEA, and β-HCG levels. |
| T12 |
1815-1960 |
Sentence |
denotes |
Patients with high CEP55 protein expression had shorter overall survival and disease-free survival compared with those with low CEP55 expression. |
| T13 |
1961-2056 |
Sentence |
denotes |
Multivariate analysis implicated CEP55 as an independent prognostic indicator for EOC patients. |
| T14 |
2057-2171 |
Sentence |
denotes |
Additionally, downregulation of CEP55 in ovarian cancer cells remarkably inhibited cellular motility and invasion. |
| T15 |
2172-2330 |
Sentence |
denotes |
Aberrant CEP55 expression may predict unfavorable clinical outcomes in EOC patients and play an important role in regulating invasion in ovarian cancer cells. |
| T16 |
2331-2407 |
Sentence |
denotes |
Thus, CEP55 may serve as a prognostic marker and therapeutic target for EOC. |
